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Biomedical and Environmental Sciences 2019年第10期32卷 755-768页

作者： ZHANG Jia Yan XIAO Xiang DONG Ying ZHOU Xing Hua School of Food and Biological Engineering Jiangsu University

Objective To further explore associated effects of Lactobacillus plantarum dy-1(LFBE) on obesity and lipid metabolism at the gene expression level, the expression of micro RNAs(mi RNAs) was investigated in the liver of high-fat diet(HFD) induced obese *** Three groups of animal models were established. Changes in mi RNA expression in the liver of each group were analyzed by microarray and RT-q PCR, complemented by bioinformatics. Palmitateinduced hepatocellular carcinoma(Hep G2) cells were used as a model to validate the *** LFBE treatment groups and HFD groups were observed to be distinctly different with respect to rates of increase in body weight and body fat percentage and triglyceride(TG) and total cholesterol(TC) levels in serum and liver. In addition, the LFBE group showed upregulation of ten mi RNAs and downregulation of five mi RNAs in the liver. Downregulation of mi R-34 a and mi R-212 was observed in the livers of the LFBE group. Gene ontology and kyoto encyelopedia of geues and genomes(KEGG)pathway analysis showed that possible target genes of the deregulated mi RNAs were significantly enriched in the adrenergic and HIF-1 signaling *** These results demonstrate that LFBE might regulate the expression of mi RNAs in order to inhibit obesity and fatty liver.

关键词： Fermented barley extract Lactobacillus plantarum dy-1 anti-obesity Lipid metabolism miRNAs Microarray

anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon Min-Cheol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan anti-obesity anti-steatosis

The inhibition mechanisms of pancreatic lipase by apigenin and its anti-obesity mechanisms revealed by using network pharmacology

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Food Bioscience 2022年第1期45卷 293-300页

作者： Fuqiang Liang Yumeng Shi Weiwei Cao Jiayi Shi College of Food Science and Engineering Collaborative Innovation Center for Modern Grain Circulation and SafetyNanjing University of Finance and EconomicsNanjing210023China College of Food Science and Bioengineering Henan University of Science and TechnologyLuoyang471023China

This study aimed to elucidate the inhibition mechanism of apigenin against porcine pancreatic lipase(PPL),and,moreover,to comprehensively reveal the molecular basis of its anti-obesity via network pharmacology *** results showed that apigenin inhibited PPL with an IC50 value of 0.377±0.041 *** techniques combined molecular docking suggested that apigenin could bind into the PPL active pocket,affecting its normal spatial ***,molecular dynamic(MD)simulations revealed that the open conformation of PPL tended to transit to the closed in the presence of apigenin,which might one important reason for the inhibition of PPL catalytic *** pharmacology analysis revealed that a total of 49 proteins could be identified as potential targets for the anti-obesity effects of *** to the protein-protein interaction(PPI)network analysis,six hub targets were extracted including IGF1,ESR1,MMP9,PPARA,MAPK14 and *** Encyclopedia of Genes and Genomes(KEGG)pathway enrichment indicated that the 49 potential targets could be mapped to 30 pathways(panti-obesity benefit through the molecular mechanisms uncovered by network *** study proposes a new strategy to reveal the mechanisms of dietary polyphenols at the level of network pharmacology.

关键词： anti-obesity Apigenin Pancreatic lipase Inhibition mechanism Molecular modeling Network pharmacology

An overview of Pu-erh tea and its health-promoting effects of lipid-lowering and anti-obesity

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Journal of Chinese Pharmaceutical Sciences 2021年第8期30卷 623-633页

作者： Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan Faculty of Applied Sciences UCSI University56000 Cher asKuala LumpurMalaysia School of Foundation Studies Xiamen University MalaysiaBandar Sunsuria43900 SepangSelangorMalaysia Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

As a dark tea,Pu-erh tea(PET)is produced from sun-dried leaves of Camellia sinensis *** mainly in Yunnan Province of *** microorganisms are involved in the fermentation of *** them,Aspergillus niger is most *** is believed that the longer the preservation period,the better is the quality and taste of PET,which is commercially available as loose,compressed or instant tea *** components of PET include flavones,flavanols,flavonols,phenolic acids,alkaloids and *** this overview,the lipid-lowering and anti-obesity effects of PET were discussed based on animal models and human trials,and our study provided some insights into possible mechanisms of bioactive compounds,such as theabrownin,catechins,lovastatin and gallic *** bioactivities of PET and some information on Fuzhuan brick tea were also *** of information cited were from Google Scholar,Pub Med,Pub Med Central,Science Direct,J-Stage,Pub Chem,Directory of Open Access Journals(DOAJ),and China National Knowledge Infrastructure(CNKI).

关键词： Pu-erh tea Fuzhuan brick tea Fermentation Lipid-lowering anti-obesity

anti-obesity, anti-Atherosclerotic and anti-Oxidant Effects of Pu-Erh Tea on a High Fat Diet-Induced Obese Rat Model

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Journal of Biosciences and Medicines 2019年第2期7卷 120-130页

作者： Changyun Xiong Yuanju Peng Benying Liu Wenrui Cui Xuncheng Liu College of Tropical Crops Yunnan Agricultural University Pu’er China Tea Research Institute Yunnan Academy of Agricultural Science Menghai China South China Botanical Garden Chinese Academy of Sciences Guangzhou China

Pu-erh tea, a traditional Chinese beverage, has been believed to have many benefits to human health and without side effects. In this study, we systematically analyzed the main active components of Pu-erh tea and investigated its anti-obesity, anti-atherosclerotic and anti-oxidant effects using an obese rat model. obesity was induced by feeding a high-fat diet and subsequently the experimental obese mice were fed with high-fat diet supplemented with low (2.5%), medium (5%) or high (7.5%) doses of Pu-erh tea powder for 6 weeks respectively. As result, the body weight gain of the rats was decreased by medium and high doses of Pu-erh tea treatments. Furthermore, the levels of serum total cholesterol (TC), triglyceride (TG) and atherosclerosis index (AI) were significantly lowered by Pu-erh tea compared to the control group. Conversely, high density lipoproteincholesterol (HDL-C) level of the rats was significantly elevated by Pu-erh tea treatments. In addition, Pu-erh tea treatments increased the activities of anti-oxidative enzymes such as superoxide dismutase (SOD) and glutathione peroxides (GSH-Px), whereas reduced the level of lipid peroxidation product malondialdehyde (MDA) in obese rats. Collectively, our find-ings revealed that Pu-erh tea exerts comprehensive benefits in anti-obesity, anti-atherosclerotic and anti-oxidant effects, therefore can be used as a promising functional food in obesity management.

关键词： Pu-Erh Tea anti-obesity anti-Atherosclerotic anti-Oxidant Obese Rat Model

Rise and fall of anti-obesity drugs

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World Journal of Diabetes 2011年第2期2卷 19-23页

作者： Bernard MY Cheung Department of Medicine the University of Hong Kong

Although it is not generally a life-threatening disease,obesity is becoming a major health problem *** can be controlled by means of drugs,and,consequently,these are required to be safe as well as *** this paper,we summarize the fate of various drugs that have been introduced for clinical use in the treatment of *** and dexfenfluramine were withdrawn because of heart valve *** suppresses appetite and increases heart rate and blood *** the Sibutramine Cardiovascular OUTcomes trial,an increase in major adverse cardiovascular events prompted its withdrawal in Europe and the United *** is an endocannabinoid receptor antagonist that reduces body weight and ameliorates some cardiovascular risk ***,adverse psychiatric side effects led to its withdrawal as *** is approved in Europe and the United States for the treatment of obesity,but its use is limited by gastrointestinal *** and caffeine are natural ingredients in foods and supplements that may help the person to lose *** the light of several failed attempts,there is a clear need to develop drugs that are effective and safe in the long term in order to successfully combat the phenomenon of obesity.

关键词： obesity anti-obesity drugs Sibutramine Rimonabant Orlistat

Bioassay-guided isolation of saikosaponins with agonistic activity on 5-hydroxytryptamine 2C receptor from Bupleurum chinense and their potential use for the treatment of obesity

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Chinese Journal of Natural Medicines 2017年第6期15卷 467-473页

作者： SUN Chang-Li GENG Chang-An HUANG Xiao-Yan MA Yun-Bao ZHENG Xiao-Hong YANG Tong-Hua CHEN Xing-Long YIN Xiu-Juan ZHANG Xue-Mei CHEN Ji-Jun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China University of Chinese Academy of Sciences Beijing 100049 China

5-Hydroxytryptamine 2C(5-HT2C) receptor is one of the major targets of anti-obesity agents, due to its role in regulation of appetite. In the present study, the 70% EtO H extract of the roots of Bupleurum chinense was revealed to have agonistic activity on 5-HT2 C receptor, and the subsequent bioassay-guided isolation led to identification of several saikosaponins as the active constituents with 5-HT2 C receptor agonistic activity in vitro and anti-obesity activity in vivo. The new compound, 22-oxosaikosaponin d(1), was determined by extensive spectroscopic analyses(HR-ESI-MS, IR, and 1D and 2D NMR). The primary structure-activity relationship study suggested that the intramolecular ether bond between C-13 and C-28 and the number of sugars at C-3 position were closely related to the 5-HT2 C receptor agonistic activity. Saikosaponin a(3), the main saponin in B. chinense, showed obviously agonistic activity on 5-HT2 C receptor with an EC50 value of 21.08 ± 0.33 μmol×L^(–1) in vitro and could reduce food intake by 39.1% and 69.2%, and weight gain by 13.6% and 16.4%, respectively, at 3.0 and 6.0 mg×kg^(–1) in vivo. This investigation provided valuable information for the potential use of B. chinense as anti-obesity agent.

关键词： Bupleurum chinense 5-hydroxytryptamine 2C(5-HT2C) receptor anti-obesity Saikosaponins

Black,pinto and white beans lower hepatic lipids in hamsters fed high fat diets by excretion of bile acids

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Food Production, Processing and Nutrition 2020年第1期2卷 249-257页

作者： Priscila L.S.Alves Jose De J Berrios James Pan Wallace H.Yokoyama Agricultural Research Service United States Department of AgricultureHealthy Processed Foods ResearchWestern Regional Research Center800 Buchanan St.AlbanyCA 94710USA

Hypolipidemic and anti-obesity properties of extruded black,pinto and white beans were examined in male Syrian hamsters fed high fat diets for 3 *** efficiency and effectiveness of extruder processing to eliminate heatlabile antinutrients were also *** fed a high fat diet containing 40%extruded black beans gained the same amount of weight as animals on a low-fat chow diet(based on AIN-93G).Total plasma cholesterol of the hamsters fed bean flour-based diets tended to be lower,ranging between 298 and 356 mg/dL,compared to 365 mg/dL for the control group and total and free liver cholesterol was about 50 and 33%lower,respectively,in the livers(freeze-dried)of hamsters fed the black turtle bean(BB)and pinto bean(PB)*** nitrogen content of the feces from hamsters fed the PB and white bean(WB)diets were 2.6x higher than the control and the excretion of deoxycholic acid(DCA)and lithocholic acid(LCA)was higher in all legume fed hamsters The results show that extrusion efficiently and economically reduces anti-nutritive factors that inhibit the digestion and absorption of proteins and carbohydrates.

关键词： Beans Extrusion anti-obesity Bile acid Mice

Reducing obesity and inflammation in mice with organically-derivatized polyoxovanadate clusters

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Chinese Chemical Letters 2023年第5期34卷 631-636页

作者： Kun Chen Guoyong Dai Shengqiu Liu Yongge Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

obesity,characterized by the dysregulation of energy balance in adipose tissue and other metabolic organs,is frequently accompanied by chronic low-grade *** long-acting insulin sensitizers,the organically-derivatized polyoxovanadates(POVs),can extend the dosing interval of antidiabetic drugs from hourly to almost *** this work,the protective activity of POVs is investigated by an eight-week in vivo experiment,in which a small amount of POVs was administrated orally to a mouse model of dietinduced obesity every *** present study shows that administration of POVs significantly decreases the body weight of mice,reduces adipose tissue accumulation,and simultaneously reduces adipose tissue *** addition,the anti-obesogenic population of i NKT cells is protected potentially by POVs,which subsequently alleviates visceral adipose tissue inflammation in high-fat-diet(HFD)-fed mice against diet-induced *** contrast,the change in body weight after POV treatment is the result of a substantial reduction in fat mass,with no obvious effects on lean body *** findings demonstrate that supplementary of POVs would be an effective way to combat obesity and metabolic disorders while lowering metabolic inflammation.

关键词： Polyoxovanadates Diet-induced obesity anti-obesity anti-inflammation Metabolic disease

Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

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Frontiers of Medicine 2018年第2期12卷 130-138页

作者： Meng Dong Jun Lin Wonchung Lim Wanzhu Jin Hyuek Jong Lee Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China The University of the Chinese Academy of Sciences Beijing 100049 China Department of Sports Medicine College of Health ScienceCheongju University Cheongju 363-764 Republic of Korea Center for Vascular Research Institute for Basic Science (IBS) Daejeon 34141 Republic of Korea

Brown adipose tissue （BAT） plays a fundamental role in maintaining body temperature by producing heat. BAT that had been know to exist only in mammals and the human neonate has received great attention for the treatment of obesity and diabetes due to its important function in energy metabolism, ever since it is recently reported that human adults have functional BAT. In addition, beige adipocytes, brown adipocytes in white adipose tissue （WAT）, have also been shown to take part in whole body metabolism. Multiple lines of evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesity and improved insulin sensitivity. Furthermore, many genes involved in BAT activation and/or the recruitment of beige cells have been found, thereby providing new promising strategies for future clinical application of BAT activation to treat obesity and metabolic diseases. This review focuses on recent advances of BAT function in the metabolic aspect and the relationship between BAT and cancer cachexia, a pathological process accompanied with decreased body weight and increased energy expenditure in cancer patients. The underlying possible mechanisms to reduce BAT mass and its activity in the elderly are also discussed.

关键词： brown adipose tissue beige adipocyte anti-obesity anti-diabetes cancer cachexia aging