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Impact of parietal cell autoantibodies and non-organ-specific autoantibodies on the treatment outcome of patients with hepatitis C virus infection: A pilot study

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World Journal of Gastroenterology 2005年第4期11卷 482-487页

作者： nikolaos K.Gatselis Sarah P.Georgiadou nikolaos Tassopoulos Kalliopi Zachou Christos Liaskos Angelos Hatzakis georgios n.dalekos Department of Internal Medicine Research Laboratory of Internal Medicine Medical SchoolUniversity of Thessaly Larissa Greece Department of Internal Medicine Western Attica Hospital AthensGreece Department of Internal Medicine Research Laboratory of Internal Medicine Medical SchoolUniversity of Thessalv Larissa.Greece Academic Liver UnitDepartment of Internal MedicineMedical SchoolUniversity of Thessaly LarissaGreece Department of Internal Medicine Research Laboratory of Internal Medicine Medical SchoolUniversity of Thessaly LarissaGreece Department of Hygiene and Epidemiology national Retrovirus Reference Center Athens University Medical SchoolAthensGreece Department of Internal Medicine Research Laboratory of Internal Medicine Medical SchoolUniversity of Thessaly LarissaGreece Academic Liver UnitDepartment of Internal MedicineMedical SchoolUniversity of Thessaly LarissaGreece

AIM: Various side effects have been reported in patients infected with hepatitis C virus (HCV) who were treated with interferon-alpha (IFn-α), including the appearance or exacerbation of underlying autoimmune diseases and the development of a variety of organ and non-organ specific autoantibodies (nOSA). However, very few studies in adults have been strictly designed to address: whether the prevalence and the titre of organ and nOSA in serial samples of HCV-treated patients were affected by IFn-α, and the impact of these autoantibodies on the treatment outcome of HCV patients. METHODS: We investigated whether parietal cell autoantibodies (PCA) and/or nOSA were related with treatment-outcome in 57 HCV-treated patients (19 sustained-responders, 16 relapsers, 22 non-responders). Serum samples from patients were studied blindly at three time-points (entry, end of treatment and end of followup). For the detection of autoantibodies we used indirect immunofluorescence, commercial and in-house ELISAs. RESULTS: Sustained biochemical response was associated with AnA-negativity at the entry or end of follow up. Sustained virological response was associated with the absence of PCA at the entry. Combined virological and biochemical sustained response (CVBSR) was associated with the absence of antinuclear antibodies (AnA) at the end of follow up and PCA-negativity at the entry. Sustained virological and CVBSR were associated with a reduction of AnA and SMA titers during therapy. COnCLUSIOn: Although PCA and/or nOSA seropositivity should not affect the decision to treat HCV patients, the presence of some of them such as AnA, PCA and SMA before treatment or their increase during therapy with IFn- a may predict a worse response, indicating the need for a closer monitoring during treatment of HCV patients positive for these autoantibodies.

关键词： HCV infection Autoantibodies Interferon-alpha

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Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis:A case report and review of the literature

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World Journal of Gastroenterology 2006年第2期12卷 336-339页

作者： nikolaos Tzovaras Aggelos Stefos Sarah P Georgiadou nikolaos Gatselis Georgia Papadamou Eirini Rigopoulou Maria Ioannou Ioannis Skoularigis georgios n dalekos Department of Medicine Academic Liver UnitMedical SchoolUniversity of Thessaly41222 LarissaGreece Department of Pathology Medical SchoolUniversity of Thessaly41222 LarissaGreece Division of Cardiology Medical SchoolUniversity of Thessaly41222 LarissaGreece

Hepatopulmonary syndrome （HPS） is defined as a clinical triad including liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations. We report a 61-year-old male presented with fatigue, long-lasting fever, loss of weight, signs of portal hypertension, hepatosplenomegaly, cholestasis and progressive dyspnoea over the last year. Clinical, laboratory and histological findings confirmed the diagnosis of granulomatous hepatitis. HPS due to hepatic granulomainduced portal hypertension was proved to be the cause of severe hypoxemia of the patient as confirmed by contrast-enhanced echocardiography. Reversion of HPS after corticosteroid therapy was confirmed by a new contrastenhanced echocardiography along with the normalization of cholestatic enzymes and improvement of the patient＇ s conditions. This is the first case of complete reversion of HPS in a non-cirrhotic patient with hepatic granuloma, indicating that intrapulmonary shunt in liver diseases is a functional phenomenon and HPS can be developed even in miscellaneous liver involvement as in this case.

关键词： Hepatopulmonary syndrome Granulomatous hepatitis Liver cirrhosis Orthodeoxia Platypnoea

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A Study on Refractive Index Sensors Based on Optical Micro-Ring Resonators

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Photonic Sensors 2017年第3期7卷 217-225页

作者： georgios n. TSIGARIDAS Department of Physics School of Applied Mathematical and Physical Sciences National Technical University of Athens Zografou Campus GR-15780 Zografou Athens Greece

In this work, the behavior of refractive index sensors based on optical micro-ring resonators is studied in detail. Using a result of waveguide perturbation theory in combination with numerical simulations, the optimum design parameters of the system, maximizing the sensitivity of the sensor, are determined. It is found that, when optimally designed, the sensor can detect relative refractive index changes of the order of △n/n≈3×10^-4, assuming that the experimental setup can detect relative wavelength shifts of the order of △λ/λ≈3×10^-5. The behavior of the system as bio-sensor has also been examined. It is found that, when optimally designed, the system can detect refractive index changes of the order of △n≈ 10^-3 for a layer thickness of t=- 10 nm, and changes in the layer thickness of the order of △t≈0.24 nm, for a refractive index change of △n=0.05.

关键词： Optical micro-ring resonators refractive index sensors bio-sensors nano-photonic sensors

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von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis

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World Journal of Gastroenterology 2016年第19期22卷 4786-4788页

作者： georgios n Kalambokis Gerasimos Baltayiannis Dimitrios Christodoulou 1^(st) Division of Internal Medicine Medical School University of Ioannina 45110 Ioannina Greece Division of Gastroenterology Medical School University of Ioannina 45110 Ioannina Greece

Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.

关键词： von Willebrand factor antigen Endothelial dysfunction Treatment Portal hypertension

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On the connection between the solutions to the Dirac and Weyl equations and the corresponding electromagnetic four-potentials

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Communications in Theoretical Physics 2020年第4期72卷 52-63页

作者： Aristides I Kechriniotis Christos A Tsonos Konstantinos K Delibasis georgios n Tsigaridas Department of Physics University of ThessalyGR 35100 LamiaGreece Department of Computer Science and Biomedical Informatics University of ThessalyGR-35100 LamiaGreece Department of Physics School of Applied Mathematical and Physical SciencesNational Technical University of AthensGR-15780 Zografou AthensGreece

In this work we study in detail the connection between the solutions to the Dirac and Weyl equations and the associated electromagnetic ***,it is proven that all solutions to the Weyl equation are degenerate,in the sense that they correspond to an infinite number of electromagnetic *** far as the solutions to the Dirac equation are concerned,it is shown that they can be classified into two *** elements of the first class correspond to one and only one four-potential,and are called non-degenerate Dirac *** the other hand,the elements of the second class correspond to an infinite number of four-potentials,and are called degenerate Dirac ***,it is proven that at least two of these fourpotentials are gauge-inequivalent,corresponding to different electromagnetic *** order to illustrate this particularly important result we have studied the degenerate solutions to the forcefree Dirac equation and shown that they correspond to massless *** have also provided explicit examples regarding solutions to the force-free Weyl equation and the Weyl equation for a constant magnetic *** all cases we have calculated the infinite number of different electromagnetic fields corresponding to these ***,we have discussed potential applications of our results in cosmology,materials science and nanoelectronics.

关键词： Dirac equation Weyl equation degenerate solutions electromagnetic four-potentials electromagnetic fields massless particles

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Haemodynamic and renal effects of tadalafil in patients with cirrhosis

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World Journal of Gastroenterology 2010年第39期16卷 5009-5010页

作者： georgios n Kalambokis Paraskevi Kosta Konstantinos Pappas Epameinondas V Tsianos 1st Division of Internal Medicine and Hepato-Gastroenterology Unit University HospitalMedical School of Ioannina Department of Radiology University Hospital Department of Cardiology University Hospital

A recent report introduced the phosphodiesterase-5 inhibition by vardenafil as a novel treatment of portal hypertension in patients with *** the herein presented"letter to the editor",the administration of tadalafil did not influence portal haemodynamics but impaired systemic haemodynamics in patients with *** observations concur with the results of a report in a previous issue of World Journal of Gastroenterology(October 2008).Moreover,tadalafil adversely affected renal function in patients with decompensated liver disease.

关键词： Tadalafil Portal hypertension Cirrhosis Ascites Phosphodiesterase-5 inhibition

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Rifaximin for the prevention of spontaneous bacterial peritonitis

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World Journal of Gastroenterology 2012年第14期18卷 1700-1702页

作者： georgios n Kalambokis Athanasia Mouzaki Maria Rodi Epameinondas V Tsianos The First Division of Internal Medicine and Hepato-Gastroenterology Unit Medical School of Ioannina45110 IoanninaGreece Division of Hematology Department of Internal MedicineMedical School26504 PatrasGreece

According to a review article by Biecker et al published in a previous issue of World Journal of Gastroenterology in March 2011,intestinal decontamination with norfloxacin remains the mainstay of primary prophylaxis of spontaneous bacterial peritonitis(SBP) at the expense of development of quinolone-resistant bacteria after long-term *** our research,the administration of a 4-wk regimen with rifaximin 1200 mg/d reduced significantly the ascitic neutrophil count in cirrhotic patients with sterile ascites in line with a significant decrease in plasma endotoxin *** observations concur with recent findings,showing a significantly reduced 5-year probability of SBP in cirrhotic patients taking rifaximin.

关键词： Rifaximin Cirrhosis Ascites Spontaneous bacterial peritonitis

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A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

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Bone Research 2020年第3期8卷 356-364页

作者： Maria A.Christou georgios ntritsos georgios Markozannes Fotis Koskeridis Spyros n.nikas David Karasik Douglas P.Kiel Evangelos Evangelou Evangelia E.ntzani Department of Hygiene and Epidemiology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrieli Faculty of Medicine Bar llan UniversitySafedIsrael Department of Epidemiology and Biostatistics Imperial College LondonLondonUK Department of Health Services Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural *** pleiotropy occurs when a single genetic element is associated with more than one *** aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association *** the discovery stage,the nHGRI-EBI Catalog was searched for genome-wide significant associations(P valueng bone-related *** was used to identify proxies of the significantly associated single nucleotide polymorphisms(SnPs)(r2=1).We then assessed putative genetic associations of this set of SnPs with femoral neck(Fn)and lumbar spine(LS)BMD data from the GEFOS *** variants were claimed at a false discovery raten-BMD andnetic markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound *** the discovery stage,72 BMD-related pleiotropic SnPs were identified,and 12 SnPs located in 11 loci on 8 chromosomes were replicated in the UK *** SnPs were associated,in addition to BMD,with 14 different *** pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological *** conclusion,12 BMD-related genome-wide significant SnPs showed pleiotropy with nonbone *** associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits.

关键词： magnesium globally Replication

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Liver transplantation for hepatoblastoma

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Hepatoma Research 2022年第1期8卷 382-392页

作者： Dimitrios n.Varvoglis Ioannis A.Ziogas georgios Tsoulfas Department of General Surgery Faculty of MedicineSchool of Human SciencesUniversity of ThessalyBiopolisLarissa 41100Greece Surgery Working Group Society of Junior DoctorsAthens 15123Greece Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232USA Department of Transplantation Surgery Aristotle University School of MedicineThessaloniki 54124Greece

Liver transplantation is the only potentially curative option for unresectable *** introduction of platinum-based chemotherapy drastically improved the survival outcomes of patients with ***,the use of neoadjuvant chemotherapy and the optimal number of cycles required in patients listed for liver transplantation,as well as the potential use of adjuvant chemotherapy,remain ***,the shortage of donor liver grafts,along with the lack of clear consensus on the management of metastatic hepatoblastoma,makes the decision on whether to proceed to liver transplantation even more complex and *** advances may optimize intraoperative imaging of both the primary tumor and metastatic sites,thus facilitating complete *** improvements,along with the wider use of social media platforms to increase public awareness,could potentially pave the way for more optimal implementation of liver transplantation for the treatment of patients with unresectable hepatoblastoma.

关键词： Hepatoblastoma liver transplantation chemotherapy liver tumors pediatric

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Complex skin modes in non-Hermitian coupled laser arrays

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Light(Science & Applications) 2022年第12期11卷 3002-3007页

作者： Yuzhou G.n.Liu Yunxuan Wei Omid Hemmatyar georgios G.Pyrialakos Pawel S.Jung Demetrios n.Christodoulides Mercedeh Khajavikhan Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA CREOL The College of Optics&PhotonicsUniversity of Central FloridaOrlandoFL 32816-2700USA Faculty of Physics Warsaw University of TechnologyKoszykowa 7500-662 WarsawPoland Department of Physics&Astronomy Dornsife College of LettersArts&SciencesUniversity of Southern CaliforniaLos AngelesCA 90089USA

From biological ecosystems to spin glasses,connectivity plays a crucial role in determining the function,dynamics,and resiliency of a *** the realm of non-Hermitian physics,the possibility of complex and asymmetric exchange interactions(|κ_(ij)|≠|κ_(ji)|)between a network of oscillators has been theoretically shown to lead to novel behaviors like delocalization,skin effect,and bulk-boundary *** archetypical lattice exhibiting the aforementioned properties is that proposed by Hatano and nelson in a series of papers in late *** the ramifications of these theoretical works in optics have been recently pursued in synthetic dimensions,the Hatano-nelson model has yet to be realized in real *** makes the implementation of these lattices challenging is the difficulty in establishing the required asymmetric exchange interactions in optical *** this work,by using active optical oscillators featuring non-Hermiticity and nonlinearity,we introduce an anisotropic exchange between the resonant elements in a lattice,an aspect that enables us to observe the non-Hermitian skin effect,phase locking,and near-field beam steering in a Hatano-nelson laser *** work opens up new regimes of phase-locking in lasers while shedding light on the fundamental physics of non-Hermitian systems.

关键词： Hermitian locking Complex

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