von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis

作     者：Georgios N Kalambokis Gerasimos Baltayiannis Dimitrios Christodoulou 

作者机构：1^(st) Division of Internal Medicine Medical School University of Ioannina 45110 Ioannina Greece Division of Gastroenterology Medical School University of Ioannina 45110 Ioannina Greece 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第19期

页      面：4786-4788页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：von Willebrand factor antigen Endothelial dysfunction Treatment Portal hypertension 

摘      要：Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.