Rifaximin for the prevention of spontaneous bacterial peritonitis

作     者：Georgios N Kalambokis Athanasia Mouzaki Maria Rodi Epameinondas V Tsianos 

作者机构：The First Division of Internal Medicine and Hepato-Gastroenterology UnitMedical School of Ioannina45110 IoanninaGreece Division of HematologyDepartment of Internal MedicineMedical School26504 PatrasGreece 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第14期

页      面：1700-1702页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Rifaximin Cirrhosis Ascites Spontaneous bacterial peritonitis 

摘      要：According to a review article by Biecker et al published in a previous issue of World Journal of Gastroenterology in March 2011,intestinal decontamination with norfloxacin remains the mainstay of primary prophylaxis of spontaneous bacterial peritonitis(SBP) at the expense of development of quinolone-resistant bacteria after long-term *** our research,the administration of a 4-wk regimen with rifaximin 1200 mg/d reduced significantly the ascitic neutrophil count in cirrhotic patients with sterile ascites in line with a significant decrease in plasma endotoxin *** observations concur with recent findings,showing a significantly reduced 5-year probability of SBP in cirrhotic patients taking rifaximin.