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Underlying mechanism of hemodynamics and intracranial aneurysm

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Chinese Neurosurgical Journal 2022年第2期8卷 120-127页

作者： Haishuang Tang Qingsong Wang Fengfeng Xu Xiaoxi Zhang Zhangwei Zeng Yazhou Yan Zhiwen Lu gaici xue Qiao Zuo Yin Luo Jianmin Liu Qinghai Huang Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RoadShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China Department of Cardiology the First Medical CentreChinese PLA General HospitalBeijing 100853People’s Republic of China

In modern society,subarachnoid hemorrhage,mostly caused by intracranial aneurysm rupture,is accompanied by high disability and mortality rate,which has become a major threat to human *** now,the etiology of intracranial aneurysm has not been entirely *** recent years,more and more studies focus on the relationship between hemodynamics and intracranial *** the physiological condition,the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood *** the blood vessels are stimulated by the continuous abnormal blood flow,the functional structure of the blood vessels changes,which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial *** review will focus on the relationship between hemodynamics and intracranial aneurysms,will discuss the mechanism of occurrence and development of intracranial aneurysms,and will provide a new perspective for the research and treatment of intracranial aneurysms.

关键词： Hemodynamics Inflammation Atherosclerosis Intracranial aneurysm

The biology of bone morphogenetic protein signaling pathway in cerebrovascular system

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Chinese Neurosurgical Journal 2021年第4期7卷 281-288页

作者： Haishuang Tang Xiaoxi Zhang gaici xue Fengfeng Xu Qingsong Wang Pengfei Yang Bo Hong Yi Xu Qinghai Huang Jianmin Liu Qiao Zuo Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RoadShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China Department of Cardiology the First Medical CentreChinese PLA General HospitalBeijing 100853People’s Republic of China

Bone morphogenetic protein belongs to transcription growth factor superfamilyβ;bone morphogenetic protein signal pathway regulates cell proliferation,differentiation,and apoptosis among different *** system supplies sufficient oxygen and blood into brain to maintain its normal *** disorder of cerebrovascular system will result into serious cerebrovascular diseases,which is gradually becoming a major threat to human health in modern *** recent decades,many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular *** review will discuss the relationship between the two aspects,aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.

关键词： Bone morphogenetic protein Hemodynamic Neovascularization Cerebrovascular diseases

Treatment delay from aneurysmal subarachnoid hemorrhage to endovascular treatment:a high-volume hospital experience

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Chinese Neurosurgical Journal 2021年第4期7卷 258-264页

作者： Xiaoxi Zhang Haishuang Tang Qiao Zuo gaici xue Guoli Duan Yi Xu Bo Hong Rui Zhao Pengfei Yang Jianmin Liu Qinghai Huang Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RdShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China

Background:Early treatment for patients with aneurysmal subarachnoid hemorrhage(aSAH)could significantly reduce the risk of re-bleeding and improve clinical *** assessed the different time intervals from the initial hemorrhage,admission,and endovascular treatment and identified the risk factors contributing to ***:Between February 2017 and December 2019,422 consecutive aSAH patients treated in a high-volume hospital were collected and *** factors contributing to admission delay and treatment delay were analyzed with univariate and multivariate ***:One hundred twenty-two(28.9%)were admitted to the high-volume hospital at the day of symptom onset and 386(91.5%)were treated with endovascular management at the same day of *** multivariate analysis found that younger age(P=0.022,OR=0.981,95%CI 0.964–0.997)and good Fisher score(P=0.002,OR=0.420,95%CI 0.245–0.721)were independent risk factors of admission *** was found to be related with treatment *** analysis(OR(95%CI))showed that higher age 1.027(1.004–1.050),poorer Fisher score 3.496(1.993–6.135),larger aneurysmal size 1.112(1.017–1.216),and shorter interval between onset to admission 1.845(1.018–3.344)were independent risk factors of poorer clinical ***:Treatment delay was mainly caused by pre-hospital delay including delayed admission and delayed *** experience showed that cerebrovascular team could provide early treatment for aSAH *** age and good Fisher score were significantly related with admission ***,admission delay was further significantly correlated with better clinical outcome.

关键词： Intracranial aneurysm Rupture Coiling with stent placement Procedure-related complication Safety

Safety and efficacy of stent-assisted coiling for acutely ruptured wide-necked intracranial aneurysms:comparison of LVIS stents with laser-cut stents

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Chinese Neurosurgical Journal 2021年第2期7卷 116-125页

作者： gaici xue Qiao Zuo Xiaoxi Zhang Haishuang Tang Rui Zhao Qiang Li Yibin Fang Pengfei Yang Bo Hong Yi Xu Qinghai Huang Jianmin Liu Department of Neurosurgery General Hospital of Southern Theatre Command of PLA111 Liuhua RoadGuangzhou 510010China Department of Neurosurgery Changhai HospitalNaval Medical University168 Changhai RoadShanghai 200433China

Background:To compare the safety and efficacy of LVIS stent-assisted coiling with those of laser-cut stent-assisted coiling for the treatment of acutely ruptured wide-necked intracranial ***:Patients with acutely ruptured wide-necked intracranial aneurysms treated with LVIS stent-assisted coiling(LVIS stent group)and laser-cut stent-assisted coiling(laser-cut stent group)were retrospectively reviewed from January 2014 to December *** score matching was used to adjust for potential differences in age,sex,aneurysm location,aneurysm size,neck width,Hunt-Hess grade,and modified Fisher *** procedure-related complications and clinical and angiographic follow-up outcomes were *** and multivariate analyses were performed to determine the associations between procedure-related complications and potential risk ***:A total of 142 patients who underwent LVIS stent-assisted coiling and 93 patients who underwent laser-cut stent-assisted coiling were enrolled after 1:2 propensity score *** angiographic follow-up outcomes showed that the LVIS stent group had a slightly higher complete occlusion rate and lower recurrence rate than the laser-cut stent group(92.7%vs 80.6%;3.7%vs 9.7%,P=0.078).The clinical outcomes at discharge and follow-up between the two groups demonstrated no significant differences(P=0.495 and P=0.875,respectively).The rates of intraprocedural thrombosis,postprocedural thrombosis,postoperative early rebleeding,and procedure-related death were 0.7%(1/142),1.4%(2/142),2.8%(4/142),and 2.1%(3/142)in the LVIS stent group,respectively,and 4.3%(4/93),2.2%(2/93),1.1%(1/93),and 3.2%(3/93)in the laser-cut stent group,respectively(P=0.082,0.649,0.651,and 0.683).Nevertheless,the rates of overall procedure-related complications and intraprocedural rupture in the LVIS stent group were significantly lower than those in the laser-cut stent group(5.6%vs 14.0%,P=0.028;0.7%vs 6.5%,P=0.016).Multivariate an

关键词： Ruptured intracranial aneurysm LVIS stent Laser-cut stent Propensity score matching

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听神经瘤术中面神经监测的研究进展

中华神经外科杂志 2020年第5期36卷 526-529页

作者：方媛刘文科惠旭辉四川大学华西医院神经外科成都610041

听神经瘤手术目前已从拯救患者生命提升至提高患者的生命质量,因而术中保护面神经对于患者术后的生命质量至关重要.术中面神经电生理监测对于保护面神经具有重要价值,不仅可实时精确辨认和定位面神经,还可评估面神经功能的完整性.目前... 详细信息

听神经瘤手术目前已从拯救患者生命提升至提高患者的生命质量,因而术中保护面神经对于患者术后的生命质量至关重要.术中面神经电生理监测对于保护面神经具有重要价值,不仅可实时精确辨认和定位面神经,还可评估面神经功能的完整性.目前的神经电生理监测技术主要包括:触发肌电图、自发肌电图及经颅面神经运动诱发电位.本文将对听神经瘤术中面神经电生理监测技术的基本原理、技术进展及其技术陷阱进行综述.

关键词：听神经瘤生命质量面神经功能肌电图面神经监测面神经电生理监测经颅患者术后

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血管内治疗创伤性椎动脉夹层动脉瘤的初步疗效观察

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中华神经外科杂志 2021年第6期37卷 546-550页

作者：唐海双薛盖茨曾张伟许峰峰杨鹏飞黄清海左乔刘建民海军军医大学第一附属医院神经外科上海200433 海军军医大学特色医学中心海战伤救治科上海200052

目的初步观察血管内治疗创伤性椎动脉夹层动脉瘤(TVAPA)的安全性和有效性。方法连续纳入2017年1月至2019年12月海军军医大学第一附属医院神经外科采用血管内治疗的14例TVADA患者。其中11例采用支架辅助弹簧圈栓塞治疗,2例采用单纯支架治... 详细信息

目的初步观察血管内治疗创伤性椎动脉夹层动脉瘤(TVAPA)的安全性和有效性。方法连续纳入2017年1月至2019年12月海军军医大学第一附属医院神经外科采用血管内治疗的14例TVADA患者。其中11例采用支架辅助弹簧圈栓塞治疗,2例采用单纯支架治疗,1例采用血流导向装置治疗。回顾性观察患者的手术相关并发症和疗效。结果14例患者均手术成功。术后即刻造影显示11例夹层动脉瘤瘤体部分显影,3例夹层动脉瘤完全闭塞。术后1例患者因脑出血死亡;1例肌力下降,经治疗后好转。12例患者接受临床随访,随访时间为(29.5±10.8)个月(12-47个月),其中格拉斯哥预后评级Ⅴ级者11例,Ⅳ级者1例。10例患者接受影像学随访.随访时间为(24.6±10.4)个月(6-40个月),夹层动脉瘤均完全闭塞。结论初步观察结果显示,血管内治疗TVADA安全.有效,可降低动脉瘤再出血的风险。

关键词：创伤和损伤动脉瘤,夹层椎动脉血管内手术

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以学生为主体的神经生物学教学改革研究

基础医学教育 2016年第1期18卷 10-13页

作者：俞仲望王彦薛盖茨曹莉何成第二军医大学神经生物学教研室上海200433 上海市第一人民医院宝山分院第二军医大学学员一队

神经科学突飞猛进对高校神经生物学教学提出了新的要求,如何在保证学科框架完整、系统的前提下与时俱进,有针对性地传授神经科学方面知识和技术,更好地培养医科大学学员,是一个重要的问题。文章根据近两年不同专业的教学实践,探讨从学... 详细信息

神经科学突飞猛进对高校神经生物学教学提出了新的要求,如何在保证学科框架完整、系统的前提下与时俱进,有针对性地传授神经科学方面知识和技术,更好地培养医科大学学员,是一个重要的问题。文章根据近两年不同专业的教学实践,探讨从学生出发、根据授课对象不同,进行课程改革的体会。

关键词：神经生物学教学方法课程改革

少突胶质前体细胞分化调控在多发性硬化病理发生中的意义

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生命的化学 2016年第6期36卷 834-841页

作者：刘明东薛盖茨蒋勇蒲颖艳曹莉第二军医大学基础部神经生物学教研室上海200433 第二军医大学上海200433

多发性硬化是一类中枢神经系统炎症性脱髓鞘疾病,其发病原因目前尚未明确。深入地研究该疾病的发生发展机制将为临床预防及治疗提供更有效的帮助。髓鞘是中枢神经系统重要的生理结构,主要发挥保护轴突和加速神经冲动传导的作用。在成年... 详细信息

多发性硬化是一类中枢神经系统炎症性脱髓鞘疾病,其发病原因目前尚未明确。深入地研究该疾病的发生发展机制将为临床预防及治疗提供更有效的帮助。髓鞘是中枢神经系统重要的生理结构,主要发挥保护轴突和加速神经冲动传导的作用。在成年中枢神经系统,髓鞘损伤后可以由少突胶质前体细胞经增殖、迁移和分化而重新形成,即髓鞘再生。然而,在慢性多发性硬化症患者的病灶中,由于少突胶质前体细胞分化障碍,导致髓鞘再生减弱,进而造成轴突损伤和神经元丢失,发生不可逆的神经功能障碍,是进展型多发性硬化发生的重要原因。因此,研究进展型多发性硬化患者病灶中少突胶质前体细胞的分化障碍及其相关信号机制对于临床治疗和药物开发具有重要意义。本综述将着眼于少突胶质前体细胞的分化调控机制,分析其在进展型多发性硬化病理发生中的作用和意义,并讨论了相关的潜在治疗靶点。

关键词：进展型多发性硬化少突胶质前体细胞再髓鞘化