The biology of bone morphogenetic protein signaling pathway in cerebrovascular system

作     者：Haishuang Tang Xiaoxi Zhang Gaici Xue Fengfeng Xu Qingsong Wang Pengfei Yang Bo Hong Yi Xu Qinghai Huang Jianmin Liu Qiao Zuo 

作者机构：Department of NeurosurgeryChanghai HospitalNaval Military Medical University168 Changhai RoadShanghai 200433People’s Republic of China Naval Medical Center of PLANaval Military Medical UniversityShanghai 200050People’s Republic of China Department of Cardiologythe First Medical CentreChinese PLA General HospitalBeijing 100853People’s Republic of China 

出 版 物：《Chinese Neurosurgical Journal》 (中华神经外科杂志（英文）)

年 卷 期：2021年第7卷第4期

页      面：281-288页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(grant No:2016YFC1300703) the National Natural Science Foundation of China(grant No:81701136,81771264) 

主　　题：Bone morphogenetic protein Hemodynamic Neovascularization Cerebrovascular diseases 

摘      要：Bone morphogenetic protein belongs to transcription growth factor superfamilyβ;bone morphogenetic protein signal pathway regulates cell proliferation,differentiation,and apoptosis among different *** system supplies sufficient oxygen and blood into brain to maintain its normal *** disorder of cerebrovascular system will result into serious cerebrovascular diseases,which is gradually becoming a major threat to human health in modern *** recent decades,many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular *** review will discuss the relationship between the two aspects,aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.