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Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits

The Journal of Biomedical Research 2019年第4期33卷 271-279页

作者： Manabu Niimi Kazutoshi Nishijima Shuji Kitajima fumikazu matsuhisa Kaneo Satoh Hirokazu Yamazaki Jifeng Zhang Y. Eugene Chen Jianglin Fan Department of Molecular Pathology Graduate School of MedicineUniversity of YamanashiYamanashi 409-3898Japan Animal Research Laboratory Bioscience Education-Research Support CenterAkita UniversityAkita 010-8502Japan Analytical Research Center for Experimental Sciences Saga UniversitySaga 840-8502Japan Department of Laboratory Medicine Graduate School of MedicineUniversity of YamanashiYamanashi 409-3898Japan Center for Advanced Models for Translational Sciences and Therapeutics University of Michigan Medical CenterAnn ArborMI 48109USA School of Biotechnology and Health Sciences Wuyi UniversityJiangmenGuangdong 529020China

Increased expression of matrix metalloproteinase-1(MMP-1)has been observed in the lesions of atherosclerosis and aneurysms;however,it is not fully understood whether macrophage-derived MMP-1 affects these *** investigate whether macrophage-derived MMP-1 participates in the development of vascular diseases,we generated transgenic(Tg)rabbits expressing human MMP-1 in the monocyte/macrophage lineage under the control of the human scavenger receptor enhancer/*** rabbits exhibited no visible abnormalities throughout their *** blotting analysis revealed that the amount of MMP-1 proteins in the conditioned media secreted from peritoneal macrophages of Tg rabbits was up to 3-fold higher than that in non-Tg *** the first experiment,Tg and non-Tg rabbits were fed a cholesterol diet for 16 weeks,and aortic and coronary atherosclerosis were *** gross lesion area of aortic atherosclerosis in Tg rabbits was not significantly different from that in non-Tg rabbits,but Tg rabbits had marked destruction of the medial elastic lamina of the aortic lesions on microscopic *** the second experiment,we generated aortic aneurysms by incubating with *** with non-Tg rabbits,Tg rabbits exhibited a significantly greater aortic *** macrophage-derived MMP-1 led to increased medial destruction in both aortic atherosclerosis and *** results demonstrate that MMP-1 plays a different role in the pathogenesis of atherosclerosis and aneurysms.

关键词： matrix metalloproteinase-1 macrophage atherosclerosis aneurysm transgenic rabbit

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Rapid,noncontact,sensitive,and semiquantitative characterization of buffered hydrogen-fluoridetreated silicon wafer surfaces by terahertz emission spectroscopy

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Light(Science & Applications) 2022年第12期11卷 2982-2993页

作者： Dongxun Yang Abdul Mannan fumikazu Murakami Masayoshi Tonouchi Institute of Laser Engineering Osaka University 2-6 YamadaokaSuitaOsaka 565-0871Japan

Advances in modern semiconductor integrated circuits have always demanded faster and more sensitive analytical methods on a large-scale *** surface of wafers is fundamentally essential to start building circuits,and quantitative measures of the surface potential,defects,contamination,passivation quality,and uniformity are subject to *** present study provides a new approach to access those by means of terahertz(THz)emission *** femtosecond laser illumination,THz radiation,which is sensitive to the surface electric fields of the wafer,is ***,we systematically research the THz emission properties of silicon surfaces under different surface conditions,such as the initial surface with a native oxide layer,a fluorine-terminated surface,and a hydrogenterminated ***,a strong doping concentration dependence of the THz emission amplitude from the silicon surface has been revealed in different surface conditions,which implies a semiquantitative connection between the THz emission and the surface band bending with the surface ***-induced THz emission spectroscopy is a promising method for evaluating local surface properties on a wafer scale.

关键词： terminated fluoride fluorine

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Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

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World Journal of Biological Chemistry 2010年第11期1卷 327-337页

作者： Koichi Sato fumikazu Okajima Laboratory of Signal Transduction Institute for Molecular and Cellular RegulationGunma University

The reverse cholesterol transport mediated by high-density lipoprotein (HDL) is an important mechanism for maintaining body cholesterol, and hence, the crucial anti-atherogenic action of the lipoprotein. Recent studies, however, have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism. The present review provides an overview of the roles of sphingosine 1-phosphate (S1P)/S1P receptor and apolipoprotein A-I/scavenger receptor class B type I systems in the anti-atherogenic HDL actions. In addition, the physiological significance of the existence of S1P in the HDL particles is discussed.

关键词： High-density lipoprotein Sphingosine 1-phosphate Scavenger receptor class B type I Anti-atherogenic actions

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Mathematical Modeling of Metal Active Gas (MAG) Arc Welding

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Journal of Materials Science & Technology 2001年第1期17卷 167-168页

作者： Takayoshi Ohji Yoko Tsuji fumikazu Miyasakn and Takeshi Yamamoto Department of Adaptive Machine Systems, Osaka University 2-l, Yamada-oka, Suita, Osaka, 565-0871, Japan Dep. of Adaptive Machine Syst. Osaka Univ. Osaka 565-0871 Japan

In the present paper. a numerical model for MAG (metal active gas) arc welding of thin plate has been developed. In MAG arc welding, the electrode wire is melted and supplied into the molten pool intermittently. Accordingly, it is assumed on the modeling that the thermal energy enters the base-plates through two following mechanisms, i.e., direct heating from arc plasma and 'indirect' heating from the deposited metal. In the second part of the paper, MAG arc welding process is numerically-analyzed by using the model. and the calculated weld bead dimension and surface profile have been compared with the experimental MAG welds on steel plate. As the result. it is made clear that the model is capable of predicting the bead profile of thin-plate MAG arc welding, including weld bead with undercutting.

关键词： POOL

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Successful treatment of hypovascular advanced hepatocellular carcinoma with lipiodol-targetting intervention radiology

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World Journal of Gastroenterology 2007年第32期13卷 4398-4400页

作者： Kazutaka Kurokohchi Akihiro Deguchi Tsutomu Masaki Takashi Himoto Hirohito Yoneyama Mitsuyoshi Kobayashi Tsuyoshi Maeta Takaaki Kiuchi fumikazu Kohi Hisaaki Miyoshi Tomohiko Taminato Shigeki Kuriyama Department of Gastroenterology and Neurology Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Laboratory MedicineKagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Gastroenterology and Neurology Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Gastroenterology KKR Takamatsu Hospital4-18 TenjinmaeTakamatsuKagawa 760-0018Japan Department of Radiology KKR Takamatsu Hospital4-18 TenjinmaeTakamatsuKagawa 760-0018Japan Department of Laboratory Medicine Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan

We report a case of hypovascular advanced hepa-tocellular carcinoma (HCC) successfully treated with a novel combination therapy of percutaneous ethanol-lipiodol injection (PELI) and intervention radiology (IVR),lipiodol-targetting IVR (Lipi-IVR). The present case had a hypovascular HCC (3 cm in diameter) located in the S6 region of the liver. Although the tumor was not detectable at all by both of early and late phase of helical dynamic computed tomography (CT),it could be detected by ultrasonography (US) as a low echoic space occupying lesion (SOL) beside the gallbladder and right kidney. Serum levels of alpha fetoprotein (AFP) and AFP-L3 were extremely high. Combination therapy of PELI,firstly reported in our department,and IVR (PELI and IVR,lipiodol-targetting IVR) was performed twice for the treatment. PELI could effectively visualize the location of the tumor for IVR treatment and show the presence of a thin blood vessel branching from the right hepatic artery flowing into the lipiodol deposit. After treatment,the serum levels of AFP and AFP-L3 were rapidly decreased to normal and maintained for more than eight months. Thus,this case expressing the tremendous effect might give us insight into the effectiveness of the novel combination therapy of PELI and IVR for the treatment of hypovascular HCC.

关键词： hepatocellular carcinoma Percutaneous ethanol-lipiodol injection therapy Intervention radiology

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Signaling Pathways Involved in Proliferation and Migration in Response to Lysophosphatidic Acid and Low-density Lipoprotein in Coronary Artery Smooth Muscle Cells

Signaling Pathways Involved in Proliferation and Migration i...

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2008年全国生物化学与分子生物学学术大会

作者： Alatan Gaole Mayumi Komachi fumikazu Okajima Labooratory of Biochemistry and Signal Transduction College of Life SciencesInner Mongolia university Institute for Molecular Cellular Regulation Gunma University

Content:Although several recent studies have shown that plasma low-density lipoprotein (LDL) or oxi- dized LDL induces DNA synthesis of vascular smooth muscle cells,it is not clear what component(s) of the

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Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis

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World Journal of Gastroenterology 2012年第40期18卷 5759-5770页

作者： fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu Department of Medical Nutrition Graduate School of Life ScienceOsaka City University Department of Hepatology Graduate School of MedicineOsaka City University Department of Hepatology Graduate School of MedicineOsaka City UniversityOsaka 545-8585Japan Department of Public Health Graduate School of MedicineOsaka City University

AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive ***:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban *** assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin *** measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer *** surveyed daily physical activity using a *** and multivariate logistic regression modeling were used to identify the relevant factors for insulin ***:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic ***(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control *** strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle *** total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the *** activity levels(kcal/d)(control vs cirrhosis,210 ± 11

关键词： Hepatitis C virus Insulin resistance Livercirrhosis Nutrition assessment Obesity Lifestyle Ex-ercise

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Long-Term Improvement in Precautions for Flood Risk Mitigation:A Case Study in the Low-Lying Area of Central Vietnam

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International Journal of Disaster Risk Science 2021年第2期12卷 250-266页

作者： Cong Dinh Nguyen Funiikazu Ubukata Quang Tan Nguyen Hoang Ha Vo Graduate School of Environmental and Life Science Okayama UniversityOkayama 700-8530Japan Faculty of Economics and Development Studies University of EconomicsHue UniversityHue City 49000Vietnam International School Hue UniversityHue City 49000Vietnam

Local actors appear as inseparable components of the integrated flood risk mitigation strategy in *** this fact,this study examined the long-term improvement in precautions taken by commune authorities and households between two major floods in 1999 and 2017 by applying both quantitative and qualitative *** flood-prone villages were selected for a survey;one in a rural area and the other in a suburban area of Thua Thien Hue Province,central *** findings indicate that most villagers doubted the structural works’efficacy and were dissatisfied with the current efforts of local ***’self-preparation thus became the decisive factor in mitigating *** most households have paid greater attention to flood precautions in 2017,others seem to be ***-related barriers were the root causes restraining households in both rural and suburban *** suburban riverine residents were further identified as vulnerable by their limitations in upgrading structural measures,which was ascribed to the inconsistency in the ancient town’s preservation *** multidimensional comparison,in terms of vulnerability,emphasized the importance of space-function links in the suburb and the contradictions of different policy initiatives,such as landscape rehabilitation,disaster prevention,and livelihood maintenance.

关键词： Central Vietnam Flood risk mitigation Long-term improvement Natural hazards Precautionary measures

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Segmentation of Sinusoids in Hematoxylin and Eosin Stained Liver Specimens Using an Orientation-Selective Filter

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Open Journal of Medical Imaging 2013年第4期3卷 144-155页

作者： Masahiro Ishikawa Sercan Taha Ahi fumikazu Kimura Masahiro Yamaguchi Hiroshi Nagahashi Akinori Hashiguchi Michiie Sakamoto Department of Pathology Graduate School of Medicine Keio University Shinjuku-ku Japan Global Scientific Information and Computing Center Tokyo Institute of Technology Meguroku Japan Global Scientific Information and Computing Center Tokyo Institute of Technology Meguroku Japan Faculty of Health & Medical Care Saitama Medical University Hidaka-shi Japan

The liver comprises cell layers of hepatocytes called trabeculae, which are separated by vascular sinusoids. Under- standing the structure of hepatic trabeculae and liver sinusoids in hematoxylin and eosin (HE)-stained liver specimens is important for the differential diagnosis of liver diseases. In this study, we develop an approach to extracting liver sinusoids from HE-stained images. The proposed approach involves: 1) a new orientation-selective filter (OS filter) for edge enhancement and image denoising, 2) the clustering of image pixels to identify candidate sinusoids, and 3) a classification procedure that discards unlikely candidates and selects the final sinusoid areas. Experimental studies using a database of 16 images with a resolution of 512 × 512 pixels showed that the proposed approach could segment liver sinusoid pixels with 81% of specificity and 94% of sensitivity. A comparison with a method based on bilateral filters showed that this method improved the sensitivity for all images with an average improvement of 4% and no difference in specificity. The results were presented to a group of pathologists and they confirmed that the images were highly representative of the tissue morphology features.

关键词： Histopathological Tissue Images Orientation-Selective Filter Segmentation of Sinusoids

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Fundamental Study of the Relationship between Cognitive Behavior and Brain Activity while Driving

Fundamental Study of the Relationship between Cognitive Beha...

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第三届亚洲机械电子学学术会议

作者： Yasuhito Yoshizawa Shunji Shimizu Nobuhide Hirai fumikazu Miwakeichi Senichiro Kikuchi Hironori Tedzuka Eiju Watanabe Graduate School of Engineering Management Tokyo University of Science Suwa Tokyo University of Science Suwa Department of Psychiatry Jichi Medical University Faculty of Engineering Chiba University Graduate School of Engineering Management Tokyo University of Science Suwa

There have been numerous single-channel measurements performed in one area of the prefrontal cortex regarding brain activity while driving.[1]The steering action while driving a vehicle is simulated,and the seated subjects move each of their hands in a clockwise and counterclockwise circular motion. Simultaneously,the brain act ivity of the subjects was measured using near infrared spectroscopy(NIRS).Since the optic pathways in the brain process information using two pathways,a ventral(objects’shape and color)and dorsal(movement and position)pathway, which are believed to be integrated in the prefrontal cortex of the frontal lobe,the area we measured was the area in the vicinity of the prefrontal cortex of the frontal *** details regarding the circular movement include holding a mouse at a desk,and drawing a circle with a diameter of about 30 *** circles are drawn at a pace of about one circle every four seconds,with the measurements taken over a durat ion of 20 s(total 5 circles).The measurement intervals consist of a 10-s break, the 20-s task,followed by another 10-s break, repeated over 5 *** subjects used in our study were all right-handed males in their twent ies who had a histor y of driving.

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