Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

作     者：Koichi Sato Fumikazu Okajima 

作者机构：Laboratory of Signal TransductionInstitute for Molecular and Cellular RegulationGunma University 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2010年第1卷第11期

页      面：327-337页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：Supported by Grants-in-Aid for scientific research from the Japan Society for the Promotion of Science No.20015008 20054003 and 21390016 

主　　题：High-density lipoprotein Sphingosine 1-phosphate Scavenger receptor class B type I Anti-atherogenic actions 

摘      要：The reverse cholesterol transport mediated by high-density lipoprotein (HDL) is an important mechanism for maintaining body cholesterol, and hence, the crucial anti-atherogenic action of the lipoprotein. Recent studies, however, have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism. The present review provides an overview of the roles of sphingosine 1-phosphate (S1P)/S1P receptor and apolipoprotein A-I/scavenger receptor class B type I systems in the anti-atherogenic HDL actions. In addition, the physiological significance of the existence of S1P in the HDL particles is discussed.