检索结果-南通市图书馆

Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling

引用

Journal of Molecular Cell Biology 2020年第7期12卷 486-498页

作者： Ping Gui Divine M.Sedzro Xiao Yuan Sikai Liu Mohan Hei Wei Tian Najdat Zohbi Fangwei Wang Yihan Yao felix o.aikhionbare Xinjiao Gao Dongmei Wang Xuebiao Yao Zhen Dou MoE Key Laboratory of Membraneless organelle and Cellular Dynamics Hefei National Laboratory for Physical Sciences at the MicroscaleSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Keck Center for Cellular Dynamics and organoids Plasticity Morehouse School of MedicineAtlantaGA 30310USA Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang UniversityHangzhou 310058China

Error-free mitosis depends on accurate chromosome attachment to spindle microtubules,which is monitored by the spindle assembly checkpoint(SAC)*** an upstream factor of SAC,the precise and dynamic kinetochore localization of Mps1 kinase is critical for initiating and silencing SAC ***,the underlying molecular mechanism remains ***,we demonstrated that the multisite interactions between Mps1 and Ndc80 complex(Ndc80C)govern Mps1 kinetochore ***,we identified direct interaction between Mps1 tetratricopeptide repeat domain and *** further identified that Mps1 C-terminal fragment,which contains the protein kinase domain and C-tail,enhances Mps1 kinetochore ***,Mps1 C-terminal fragment mediates its *** of C-tail attenuates the kinetochore targeting and activity of Mps1,leading to aberrant mitosis due to compromised SAC *** together,our study highlights the importance of Mps1 dimerization and multisite interactions with Ndc80C in enabling responsive SAC signaling.

关键词： mitosis spindle assembly checkpoint kinetochore Mps1 kinase Ndc80 complex

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver

引用

Journal of Molecular Cell Biology 2016年第2期8卷 144-156页

作者： Dong Liu Xing Liu Ti Zhou William Yao Jun Zhao Zhigang Zheng Wei Jiang Fengsong Wang felix o.aikhionbare Donald L.Hill Nerimah Emmett Zhen Guo Dongmei Wang Xuebiao Yao Yong Chen Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Anhui Key Laboratory of Cellular Dynamics and Hefei National Laboratory for Physical Sciences at Nanoscale Hefei 230027China Atlanta Clinical&Translational Science Institute AtlantaGA 30310USA Department of Pathology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Biochemistry Anhui Medical UniversityHefei 230027China Comprehensive Cancer Center University of Alabama at BirminghamBirminghamAL 35294USA Department of Hepatobiliary Surgery Navy General HospitalBeijing 100048China

Endoplasmic reticulum(ER)stress is involved in ischemic preconditioning that protects various organs from ischemia/reperfusion(I/R)*** established an in vivo ER stress preconditioning model in which tunicamycin was injected into rats before hepatic I/*** hepatic I/R injury,demonstrated by serum aminotransferase level and the ultra-structure of the liver,was alleviated by administration of tunicamycin,which induced ER stress in rat liver by activating inositol-requiring enzyme1(IRE1)andupregulating78 kDaglucose-regulated protein(GRP78).The proteomic identification for IRE1 binders revealed interaction and cooperation among receptor for activated C kinase 1(RACK1),phosphorylated AMPK,and IRE1 under ER stress conditions in a spatiotemporal ***,in vitro ER stress preconditioningwas induced by thapsigargin and tunicamycin in L02 and Hep G2 ***,BCL2 was found to bephosphorylated by IRE1 under ER stress conditions to prevent apoptotic process by activation of *** conclusion,ER stress preconditioning protects against hepatic I/R injury,which is orchestrated by IRE1-RACK1 axis through the activation of *** findings provide novel insights into the molecular pathways underlying ER stress preconditioning-elicited cytoprotective effect against hepatic I/R injury.

关键词： IRE1 RACK1 AMPK BCL2 ER stress preconditioning ischemia/reperfusion injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

引用

Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis

引用

Journal of Molecular Cell Biology 2022年第8期14卷 53-66页

作者： Hameed Akbar Jun Cao Dongmei Wang Xiao Yuan Manjuan Zhang Saravanakumar Muthusamy Xiaoyu Song Xu Liu felix aikhionbare Xuebiao Yao Xinjiao Gao Xing Liu MoE Key Laboratory for Cellular Dynamics and School of Life Sciences University of Science and Technology of ChinaHefei 230027China CAS Center for Excellence in Molecular and Cell Sciences Anhui Key Laboratory for Cellular Dynamics and Chemical BiologyHefei 230027China Morehouse School of Medicine AtlantaGA 30310USA

Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome *** eukaryotic cells,nuclear envelope breakdown(NEBD)is required for proper chromosome *** a list of mitotic kinases has been implicated in NEBD,how they coordinate their activity to dissolve the nuclear envelope and protein machinery such as nuclear pore complexes was ***,we identified a regulatory mechanism in which Nup62 is acetylated by TIP60 in human cell ***62 is a novel substrate of TIP60,and the acetylation of Lys432 by TIP60 dissolves nucleoporin Nup62-Nup58-Nup54 complex during entry into ***,this acetylation-elicited remodeling of nucleoporin complex promotes the distribution of Nup62 to the mitotic spindle,which is indispensable for orchestrating correct spindle ***,suppression of Nup62 perturbs accurate chromosome segregation during *** results establish a previously uncharacterized regulatory mechanism in which TIP60-elicited nucleoporin dynamics promotes chromosome segregation in mitosis.

关键词： mitosis spindle Nup62 TIP60 acetylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential Measurements of oxidatively Modified Proteins in Colorectal Adenopolyps

引用

International Journal of Clinical Medicine 2015年第4期6卷 289-299页

作者： Sharifeh Mehrabi Lashanale Wallace Shakeria Cohen Xuebiao Yao felix o. aikhionbare Department of Medicine Morehouse School of Medicine Atlanta USA Department of Physiology Morehouse School of Medicine Atlanta USA

Introduction: Adenopolyps patients have a three-fold higher risk of colon cancer over the general population, which increases to six-fold if the polyps are multiple and with lower survival among African American population. Currently, 6% of CRC can be ascribed to mutations in particular genes. Moreover, the optimal management of patients with colorectal adenopolyps depends on the accuracy of appropriate staging strategies because patients with similar colorectal adenocarcinoma architecture display heterogeneity in the course and outcome of the disease. oxidative stress, due to an imbalance between reactive oxygen species (RoS) and antioxidant capacities as well as a disruption of redox signaling, causes a wide range of damage to DNA, proteins, and lipids which promote tumor formation. objective/Method: This study applied spectrophotometric, dinitrophenylhydrazone (DNPH) assay, two-dimensional gel electrophoresis, and western blot analyses to assess the levels of oxidatively modified proteins in 41 pairs of primary colorectal tissues including normal/surrounding, adenopolyps (tubular, tubulovillous, villous, polypvillous) and carcinoma. Analysis of variance (ANoVA) and Student’s t-tests were utilized for the resulting data set. Results: our data showed that the levels of reactive protein carbonyl groups significantly increased as colorectal adenopolyps progresses to malignancy. No significant differences were found in the levels of carbonyl proteins between gender samples analyzed. For African American patients, there were, relative to Caucasians, 10% higher levels of reactive carbonyls in proteins of tubulovillous tissue samples

关键词： Colorectal Adenopolyps oxidative Stress Carbonyl Proteins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis

引用

Journal of Molecular Cell Biology 2024年第2期16卷 11-23页

作者： Wei Liu Zhen Dou Chunyue Wang Gangyin Zhao Fengge Wu Chunli Wang felix aikhionbare Mingliang Ye Divine Mensah Sedzro Zhenye Yang Chuanhai Fu Zhikai Wang Xinjiao Gao Xuebiao Yao Xiaoyu Song Xing Liu MoE Key Laboratory for Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Keck Center for Cellular Dynamics and organoids Plasticity AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230026China National Chromatographic Research and Analysis Center Chinese Academy of SciencesDalian 116023China

Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle *** are captured by individual microtubules via a kinetochore constitutive centromere-associated network(CCAN)during chromosome *** contains 16 subunits,including CENP-W and ***,the molecular recognition and mitotic regulation of the CCAN assembly remain ***,we revealed that CENP-W binds to the histone fold domain and an uncharacterized N-terminal region of *** B phosphorylates CENP-W at threonine 60,which enhances the interaction between CENP-W and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in *** findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability.

关键词： mitosis kinetochore Aurora B CENP-T CENP-W phosphorylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of radiation pressure and circumstellar dust on motion of a test particle in Manev’s field

引用

Astrodynamics 2021年第2期5卷 77-89页

作者： Jagadish Singh Solomon okpanachi omale Lawrence o.Inumoh felix Ale Department of Mathematics Faculty of Physical SciencesAhmadu Bello UniversityZariaNigeria Engineering and Space Systems Department National Space Research and Development Agency(NASRDA)Obasanjo Space CentreAbujaNigeria

In this paper,we present a study on the impact of radiation pressure and circumstellar dust on the motion of a test particle in the framework of the restricted four-body problem under the Manev’s *** show that the distribution of equilibrium points on the plane of motion is slightly different from that of the classical Newtonian *** the aid of the Lyapunov characteristic exponents,we show that the system is sensitive to changes in initial conditions;hence,the orbit of the system is found to be chaotic in the phase space for the given initial ***,a numerical application of this model to a stellar system(Gliese 667C)is considered,which validates the dependence of the equilibrium points on the mass *** show that the non-collinear equilibrium points of this stellar system are distributed symmetrically about the x-axis,and five of them are linearly *** basins of attraction of the system show that the equilibrium points have irregular boundaries,and we use the energy integral and the Manev parameter to illustrate the zero-velocity curves showing the permissible region of motion of the test particle with respect to the Jacobi constant.

关键词： Manev potential circumstellar dust Lyapunov characteristic exponents(LCEs) stability chaos basins of attraction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres

引用

Journal of Molecular Cell Biology 2023年第6期15卷 68-71页

作者： Junying Li Xiao Yuan Fengrui Yang Jun Cao Chunyue Wang Saima Akram Peng Zou felix aikhionbare Xuejun Li Yong Chen Liangyu Zhang Chuanhai Fu Zhikai Wang Xing Liu Xuebiao Yao MoE Key Laboratory for Membraneless organelles and Cellular Dynamics Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230027China Keck Center for organoid Plasticity AtlantaGA 30310USA Peking-Tsinghua Center for Life Sciences Peking UniversityBeĳing 100871China Department of Gastroenterology Anhui University of Chinese MedicineHefei 230038China Department of Hepatobiliary Surgery Xĳing HospitalFourth Military Medical UniversityXi’an 710033China

Dear Editor,Promyelocytic leukemia(PML)is the scaffold protein that organizes PML bod-ies,which are nuclear membraneless organelles involved in various biologi-cal processes,including tumor suppres-sion and antiviral responses(Ugge et al.,2022).Early electron microscopic analy-ses revealed contacts between the sur-face of PML bodies and chromatin struc-ture(Corpet et al.,2020).In fact,sev-eral chromatin and cell cycle regulators,such as TIP60,P300,and heterochro-matin protein 1(HP1),are localized in PML bodies in interphase cells(Corpet et al.,2020).

关键词： P300 leukemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis

引用

Journal of Molecular Cell Biology 2023年第6期15卷 53-64页

作者： Ran Liu Zhen Dou Tian Tian Xinjiao Gao Lili Chen Xiao Yuan Chunyue Wang Jiahe Hao Ping Gui McKay Mullen felix aikhionbare Liwen Niu Guoqiang Bi Peng Zou Xuan Zhang Chuanhai Fu Xuebiao Yao Jianye Zang Xing Liu MoE Key Laboratory for Cellular Dynamics&Hefei National Research Center for Interdisciplinary Sciences at the Microscale University of Science and Technology of China School of Life SciencesHefei 230026China CAS Center for Excellence in Molecular and Cell Sciences Anhui Key Laboratory for Cellular Dynamics and Chemical BiologyHefei 230027China Keck Center for Cellular Dynamics Morehouse School of MedicineAtlantaGA 30310USA College of Chemistry and Molecular Engineering Peking UniversityBeĳing 100871China

In mitosis,accurate chromosome segregation depends on the kinetochore,a supermolecular machinery that couples dynamic spin-dle microtubules to centromeric ***,the structure–activity relationship of the constitutive centromere-associated network(CCAN)during mitosis remains *** on our recent cryo-electron microscopic analyses of human CCAN structure,we investigated how dynamic phosphorylation of human CENP-N regulates accurate chromosome *** mass spectrometric analyses revealed mitotic phosphorylation of CENP-N by CDK1,which modulates the CENP-L–CENP-N interaction for accurate chromosome segregation and CCAN *** of CENP-N phosphorylation is shown to prevent proper chromosome alignment and activate the spindle assembly *** analyses provide mechanistic insight into a previously undefined link between the centromere–kinetochore network and accurate chromosome segregation.

关键词： mitosis centromere CENP-N CDK1 phosphorylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The German Energiewende and its roll-out of renewableenergies： An economic perspective

引用

Frontiers in Energy 2017年第2期11卷 126-134页

作者： Sebastian KREUZ felix MUSGENS Faculty of Mechanical Engineering Electrical and Energy SystemsBrandenburg University of Technology 03046 Cottbus Germany

This paper gives a short overview of the German Energiewende, i.e. the transition of a large and mostly thermal electricity system towards electricity generation from renewable energy source. It discusses both, the motivation of the transitions as future goals and current status. Furthermore, it gives an in-depth view into the changes in economic costs for society as well as electricity price effects, especially for average private households and industrial consumers. It also discusses the benefits of the promotion of renewable energies in Germany.

关键词： electricity system renewable energy cost-benefit analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：