Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

作     者：Daniel Adam Felix Langerscheidt Hans Zempel Daniel Adam;Felix Langerscheidt;Hans Zempel

作者机构：Institute of Human GeneticsUniversity Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC)University of CologneCologneGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第5期

页      面：1407-1408页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

主　　题：Alzheimer tau diseases 

摘      要：TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termedtauopathies,including Alzheimer s disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).