PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres

作     者：Junying Li Xiao Yuan Fengrui Yang Jun Cao Chunyue Wang Saima Akram Peng Zou Felix Aikhionbare Xuejun Li Yong Chen Liangyu Zhang Chuanhai Fu Zhikai Wang Xing Liu Xuebiao Yao Junying Li;Xiao Yuan;Fengrui Yang;Jun Cao;Chunyue Wang;Saima Akram;Peng Zou;Felix Aikhionbare;Xuejun Li;Yong Chen;Liangyu Zhang;Chuanhai Fu;Zhikai Wang;Xing Liu;Xuebiao Yao

作者机构：MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical BiologyHefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230027China Keck Center for Organoid PlasticityAtlantaGA 30310USA Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Department of GastroenterologyAnhui University of Chinese MedicineHefei 230038China Department of Hepatobiliary SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710033China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2023年第15卷第6期

页      面：68-71页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Ministry of Science and Technology of the People’s Republic of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,92153302,2022YFA0806800,2022YFA1302700,2017YFA0503600,31621002,91853115,21922706,22177106) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000) the Ministry of Education(IRT_17R102 and 2011340213001) the Fundamental Research Funds for the Central Universities(WK2070000194) 

主　　题：P300 leukemia 

摘      要：Dear Editor,Promyelocytic leukemia(PML)is the scaffold protein that organizes PML bod-ies,which are nuclear membraneless organelles involved in various biologi-cal processes,including tumor suppres-sion and antiviral responses(Ugge et al.,2022).Early electron microscopic analy-ses revealed contacts between the sur-face of PML bodies and chromatin struc-ture(Corpet et al.,2020).In fact,sev-eral chromatin and cell cycle regulators,such as TIP60,P300,and heterochro-matin protein 1(HP1),are localized in PML bodies in interphase cells(Corpet et al.,2020).