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A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis

Regenerative Biomaterials 2024年第3期3卷 122-133页

作者： Jiaqi Hao Huawei Cai Lei Gu Yiqi Ma Yan Li Beibei Liu Hongyan Zhu fanxin zeng Min Wu Department of Radiology and Huaxi MR Research Center(HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610041China Department of Nuclear Medicine&Laboratory of Clinical Nuclear Medicine West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Clinical Research Center Dazhou Central HospitalDazhouSichuan 635000China

The prognosis of glioblastoma(GBM)remains challenging,primarily due to the lack of a precise,effective imaging technique for comprehensively *** GBM diagnostic challenges,our study introduces an innovative dual-modal imaging that merges near-infrared(NIR)fluorescent imaging with magnetic resonance imaging(MR).This method employs superparamagnetic iron oxide nanoparticies coated with NIR fluorescent dyes,specifically Cyanine 7,and targeted *** synthetic probe facilitates MRI functionality through superparamagnetic iron oxide nanoparticles,provides NIR imaging capability via Cyanine 7 and enhances tumor targeting trough peptide interactions,offering a comprehensive diagnostic tool for ***,the probe traverses the blood-brain barrier,targeting GBM in vivo via peptides,producing clear and discermible images in both *** and histopathology assessments confirm the probe's favorable safet *** findings suggest that the dual-modal MRINIR fluorescent imaging probe could revolutionize GBM prognosis and survival rate which can also be extended to other tumors type.

关键词： glioblastoma magnetic resonance imaging dual-modal probes near-infrared fluorescent targeting peptides

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空间结构模型优化的弹性参数FFT-MA随机建模

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石油地球物理勘探 2024年第5期59卷 1121-1131页

作者：黄国娇曾繁鑫王善涛张宏兵蒋甫玉河海大学地球科学与工程学院江苏南京211100 青岛市水利勘测设计研究院有限公司山东青岛266071

快速傅里叶变换滑动平均(FFT-MA)法是一种灵活高效的随机建模方法,在地下介质高分辨率建模、复杂介质非平稳建模和不确定性评价等方面具有重要的应用价值。准确构建空间结构模型是利用FFT-MA方法生成合理的随机模型的关键。然而,以往对F... 详细信息

快速傅里叶变换滑动平均(FFT-MA)法是一种灵活高效的随机建模方法,在地下介质高分辨率建模、复杂介质非平稳建模和不确定性评价等方面具有重要的应用价值。准确构建空间结构模型是利用FFT-MA方法生成合理的随机模型的关键。然而,以往对FFT-MA方法的研究并未提出准确构建空间结构模型的有效方法。为此,文中提出了一种有效的空间结构模型估计方法。该方法基于反演思想,通过最小化随机模型与测井数据和地震数据的空间结构差异,分别估计空间结构模型的纵向自相关长度和横向自相关长度。同时,为了优化空间结构模型的估计效果,在纵向自相关长度的反演过程中引入边界保护正则化,以提高反演的稳定性。此外,将地震约束引入模型优选以提高随机模型的稳定性。实验结果表明:该方法能够稳定估计地下介质的非平稳空间结构模型,从而建立准确描述复杂储层非平稳空间相关特征的高分辨率随机模型。与基于序贯高斯协模拟的随机建模方法相比,使用空间结构模型优化的FFT-MA随机建模方法能够有效刻画多种复杂地质构造从而实现复杂储层建模。

关键词： FFT-MA 方法空间结构模型参数反演边界保护正则化随机建模非平稳性建模

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口服选择性雌激素受体降解剂抗乳腺癌新药艾拉司群

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世界临床药物 2024年第3期45卷 338-340页

作者：曾凡新王柯厶重庆城市管理职业学院智慧康养学院重庆401331 重庆医药高等专科学校药学院重庆401331

选择性雌激素受体降解剂(selective estrogen receptor degrader,SERD)是雌激素受体(estrogen receptor,ER)阳性的晚期乳腺癌(breast cancer)内分泌治疗的常用药物。艾拉司群(elacestrant)是治疗晚期乳腺癌ER阳性,人表皮细胞生长因子受体(human epidermal growth factor receptor,HER)2阴性的新型口服SERD,疗效优于其他内分泌治疗,可显著改善患者中位无进展生存期,且对于ER基因α突变的乳腺癌患者有效。艾拉司群的上市将为ER阳性、HER2阴性的晚期乳腺癌患者提供更有效的治疗药物选择。

关键词：选择性雌激素受体降解剂乳腺癌艾拉司群临床疗效安全性

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New Construction of Quadriphase Golay Complementary Pairs

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Chinese Journal of Electronics 2023年第5期32卷 1059-1065页

作者： LI Guojun zeng fanxin YE Changrong Lab of Beyond LOS Reliable Information Transmission Chongqing University of Posts and Telecommunications

Based on an arbitrarily-chosen binary Golay complementary pair(BGCP)(c,d) of even length N, first of all, construct quadriphase sequences a and b of length N by weighting addition and difference of the aforementioned pair with different weights, ***, new quadriphase sequence u is given by interleaving three sequences d, a, and-c, and similarly, the sequence v is acquired from three sequences d, b, and ***, the resultant pair(u,v) is the quadriphase Golay complementary pair(QGCP) of length 3N. The QGCPs play a fairly important role in communications, radar, and so on.

关键词： Histograms Systematics Computer simulation Radar

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数字化驱动社区体育公共服务体系建设的理论基础、价值取向与实践路径

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安徽体育科技 2024年第4期45卷 17-22页

作者：苏明行曾凡鑫杨前程曲阜师范大学体育科学学院山东曲阜273100 湖南工业大学体育学院湖南株洲412007

运用文献资料、逻辑分析等研究方法,对数字化驱动社区体育公共服务体系建设的理论基础、价值取向及实践路径进行深度探究。研究认为:实现社区体育公共服务供给均等化、推进社区体育公共服务内容标准化、加快社区体育公共服务建设智能化... 详细信息

运用文献资料、逻辑分析等研究方法,对数字化驱动社区体育公共服务体系建设的理论基础、价值取向及实践路径进行深度探究。研究认为:实现社区体育公共服务供给均等化、推进社区体育公共服务内容标准化、加快社区体育公共服务建设智能化等是数字化驱动社区体育公共服务体系建设的价值取向。在此基础上,进一步发掘和廓清数字化推进渗透社区领域的症结所在,试行提出强化政策落实,保障数字安全,加强人才培育,注重民生需求等纾解举措。

关键词：数字化社区体育公共服务体系价值取向路径

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数字助力农村公共体育服务更高水平发展的价值、机理与进路

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辽宁体育科技 2024年第3期46卷 60-66页

作者：苏明行曾凡鑫杨前程曲阜师范大学体育科学学院山东曲阜273100 湖南工业大学体育学院湖南株洲412007

在数字中国、智慧乡村战略引领下,农村公共体育服务治理范式迎来新契机、新机遇。运用文献资料法,对数字助力农村公共体育服务更高水平发展的价值取向、运行机理与实践进路进行研究。结果显示:以人民为中心,实现体育服务供给均等化;以... 详细信息

在数字中国、智慧乡村战略引领下,农村公共体育服务治理范式迎来新契机、新机遇。运用文献资料法,对数字助力农村公共体育服务更高水平发展的价值取向、运行机理与实践进路进行研究。结果显示:以人民为中心,实现体育服务供给均等化;以技术为支撑,务实体育基础设施信息化;以合作为导向,共筑体育服务治理高效化是数字助力农村公共体育服务的价值取向。运行机理为数字技术内部蕴含着转变农村公共体育服务供给方式,提升农村公共体育服务的供给效能,强化农村公共体育服务的治理能力。实践进路为:精准为重,增强数字技术嵌入的靶向性;共治为纲,推动多元供给主体的协同性;人才为先,完善数字人才培养的锚向性;效率为要,提升资源配置效率的强韧性。

关键词：数字技术农村公共体育服务高质量发展

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Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

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Light(Science & Applications) 2020年第1期9卷 450-465页

作者： Yanfeng Dai Xiang Yu Jianshuang Wei fanxin zeng Yiran Li Xiaoquan Yang Qingming Luo Zhihong Zhang Britton Chance Center and MOE Key Laboratory for Biomedical Photonics School of Engineering SciencesWuhan National Laboratory for Optoelectronics–Huazhong University of Science and TechnologyWuhanHubei 430074China School of Biomedical Engineering Hainan UniversityHaikouHainan 570228China

Detection of sentinel lymph nodes(SLNs)is critical to guide the treatment of breast ***,distinguishing metastatic SLNs from normal and inflamed lymph nodes(LNs)during surgical resection remains a ***,we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle(5K-HA-HPPS)loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast *** small sized(~40 nm)self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal *** with normal popliteal LNs(N-LN),there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs(T-MLN)and inflamed LNs(Inf-LN),respectively,6 h after nanoparticle *** importantly,photoacoustic microscopy(PAM)of 5KHA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and *** were mainly distributed at the centre of T-MLN but at the periphery of N-LN and *** ratio of PA intensity(R)at the centre of the LNs compared with that at the periphery was 5.93±0.75 for T-MLNs of the 5K-HA-HPPS group,which was much higher than that for the Inf-LNs(R=0.2±0.07)and N-LNs(R=0.45±0.09).These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs,thus guiding the removal of SLNs during breast cancer surgery.

关键词： breast injection cancer

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Enhanced cycling stability of antimony anode by downsizing particle and combining carbon nanotube for high-performance sodium-ion batteries

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Journal of Materials Science & Technology 2020年第20期52卷 81-88页

作者： Chuang Liu fanxin zeng Li Xu Shuangyu Liu Jincheng Liu Xinping Ai Hanxi Yang Yuliang Cao College of Chemistry and Molecular Sciences Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and EnergyWuhan UniversityWuhan 430072China State Key Laboratory of Advanced Transmission Technology Global Energy Interconnection Research Institute Co.Ltd.Beijing 102211China EVE Energy Co.ltd. No.36Huifeng 7th RoadZhongkai Hi-Tech ZoneHuizhouChina

Antimony(Sb)nanoparticles(SbNP)encapsulated in multiwalled carbon nanotubes(MWCNTs)matrix has been fabricated by a facile two-step ball milling strategy,including a sand milling process to prepare Sb nanoparticles and following high-energy ball milling to synthesize SbNP-MWCNT *** an anode material for sodium-ion batteries(SIBs),the SbNP-MWCNT composite with high Sb content(80%)can deliver a reversible capacity of 471.1 mA hg^(-1)at 50 mA g^(-1)with an initial coulombic efficiency of 73.5%,excellent cycling stability(94.1%capacity retention at 800 mA g^(-1))and high rate capability(210.7 mA h g^(-1)at 3200 mA g^(-1)).The excellent electrochemical performance of the SbNP-MWCNT composite results from the synergistic effect of downsizing Sb particles and combining MWCNTs.

关键词： Antimony Nanoparticles Carbon nanotubes Anode Sodium ion battery Mechanical ball milling

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Dynamic blood single-cell immune responses in patients with COVID-19

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1280-1291页

作者： Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao zeng Mei Luo Fanwei zeng fanxin zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuanChina Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuanChina Institute of Health Management Health Management CenterSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Department of Infection Disease Zigong First Peopled HospitalZigongSichuanChina Department of Infection Disease Mianyang No.404 HospitalMianyangSichuanChina Infectious diseases laboratory Public Health and Clinical Center of ChengduChengduSichuanChina Sichuan Dazhou Central Hosptical DazhouSichuanChina Department of Infection Disease Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina

The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health ***,the virus'pathogenesis remains unclear,and there is no cure for the *** investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell *** obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic *** addition,we used three control *** found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical *** type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions *** with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 *** concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of *** and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 *** study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic poten

关键词： patients interferon lymphocytes

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Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2870-2882页

作者： Ruoxi Xie Zijun Wu fanxin zeng Huawei Cai Dan Wang Lei Gu Hongyan Zhu Su Lui Gang Guo Bin Song Jinxing Li Min Wu Qiyong Gong Huaxi MR Research Center(HMRRC) Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduChina Department of Clinic Medical Center Dazhou Central HospitalDazhouChina Laboratory of Clinical Nuclear Medicine Department of Nuclear MedicineWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina Department of Chemical Engineering Stanford UniversityStanfordCaliforniaUSA

Glioblastoma(GBM),one of the most common primary intracranial malignant tumours,is very difficult to be completely excised by surgery due to its irregular ***,we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles(SPIONs)modified with indocyanine(Cy7)molecules and peptides(ANG orDANG)to locate malignant gliomas and guide accurate *** peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro.

关键词： tumour malignant surgery

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