Dynamic blood single-cell immune responses in patients with COVID-19
作者机构：The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory MedicineSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026)Sichuan Academy of Medical SciencesChengduSichuanChina Natural Products Research CenterInstitute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuanChina Institute of Health ManagementHealth Management CenterSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Department of Infection DiseaseZigong First Peopled HospitalZigongSichuanChina Department of Infection DiseaseMianyang No.404 HospitalMianyangSichuanChina Infectious diseases laboratoryPublic Health and Clinical Center of ChengduChengduSichuanChina Sichuan Dazhou Central HospticalDazhouSichuanChina Department of Infection DiseaseSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第4期
页 面：1280-1291页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by the Sichuan Science and Technology Program(2020YFS0014 and 2020YFS0558) the Chinese Academy of Medical Sciences(NO.2019-I2M-5-032) the National Key Research and Development Program of China(2016YFC20160905200) the National Natural Science Foundation of China(81790643,81970839 and 81670895)
主 题：patients interferon lymphocytes
摘 要：The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health ***,the virus pathogenesis remains unclear,and there is no cure for the *** investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5 gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell *** obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic *** addition,we used three control *** found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical *** type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions *** with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 *** concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of *** and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 *** study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic poten
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