Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

作     者：Ruoxi Xie Zijun Wu Fanxin Zeng Huawei Cai Dan Wang Lei Gu Hongyan Zhu Su Lui Gang Guo Bin Song Jinxing Li Min Wu Qiyong Gong Ruoxi Xie;Zijun Wu;Fanxin Zeng;Huawei Cai;Dan Wang;Lei Gu;Hongyan Zhu;Su Lui;Gang Guo;Bin Song;Jinxing Li;Min Wu;Qiyong Gong

作者机构：Huaxi MR Research Center(HMRRC)Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengduChina Department of Clinic Medical CenterDazhou Central HospitalDazhouChina Laboratory of Clinical Nuclear MedicineDepartment of Nuclear MedicineWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina Department of Chemical EngineeringStanford UniversityStanfordCaliforniaUSA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第9期

页      面：2870-2882页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the Natural Science Foundation of China(Grant 81501462,81621003) the Sichuan Science and Technology Program(Grant 2019YJ0116) the Chengdu International Science and Technology Cooperation Funding(Grant 2019-GH02-00074-HZ) the 1-3-5 Project for Disciplines of Excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University and the Functional and Molecular Imaging Key Laboratory of Sichuan Province(Grant 2012J00011) 

主　　题：tumour malignant surgery 

摘      要：Glioblastoma(GBM),one of the most common primary intracranial malignant tumours,is very difficult to be completely excised by surgery due to its irregular ***,we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles(SPIONs)modified with indocyanine(Cy7)molecules and peptides(ANG orDANG)to locate malignant gliomas and guide accurate *** peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro.