检索结果-南通市图书馆

Neuroinflammation revisited through the microglial lens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Stem cell treatments for oropharyngeal dysphagia:Rationale,benefits,and challenges

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2020年第9期12卷 1001-1012页

作者： eric K Tran Kevin o Juarez Jennifer L long David Geffen School of Medicine University of California-Los AngelesLos AngelesCA 90095United States Department of otolaryngology Yale School of MedicineNew HavenCT 06511United States Department of Head and Neck Surgery David Geffen School of MedicineUniversity of California-Los AngelesLos AngelesCA 90095United States Greater Los Angeles VA Healthcare System Los AngelesCA 90073United States

Dysphagia,defined as difficulty swallowing,is a common symptom negatively impacting millions of adults *** prevalence ranges from 14 to 33 percent in those over age 65 to over 70 percent in a nursing home *** elderly,those with neurodegenerative diseases,head and neck cancer patients,and those with autoimmune conditions such as Sjögren's syndrome are disproportionately *** dysphagia refers specifically to difficulty in initiating a swallow due to dysfunction at or above the upper esophageal sphincter,and represents a large proportion of dysphagia *** treatments are limited and are often *** cell therapy is a new and novel advancement that may fill a much-needed role in our treatment ***,we review the current literature regarding stem cell treatments for oropharyngeal *** discussed include tissue regeneration advancements as a whole and translation of these principles into research surrounding tongue dysfunction,xerostomia,cricopharyngeal dysfunction,and finally an overview of the challenges and future directions for *** this field of study remains in its early stages,initial promising results show potential for the use of stem cell-based therapies to treat oropharyngeal dysphagia and warrant further research.

关键词： Dysphagia Xerostomia Hemiglossectomy Stem cells Myoblasts Mesenchymal stem cells

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration o353.4

Coupled Perturbed Modes over Sloping Penetrable Bottom

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2017年第7期34卷 126-129页

作者： Fei-long Zhu eric I. Thorsos Feng-Hua Li State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences Beijing 100190 University of Chinese Academy of Sciences Beijing 100049 Applied Physics Laboratory University of Washington WA 98105 USA

In environments with water depth variations, one-way modal solutions involve mode coupling. Higham and Tindle developed an accurate and fast approach using perturbation theory to locally determine the change in mode functions at steps. The method of Higham and Tindle is limited to low frequency （≤250 Hz）. We extend the coupled perturbation method, thus it can be applied to higher frequencies. The approach is described and some examples are given.

关键词： Coupled Perturbed Modes over Sloping Penetrable Bottom

Going visible:high-resolution coherent Raman imaging of cells and tissues

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 1089-1090页

作者： Richard C.Prince eric o.Potma Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA Department of Chemistry University of CaliforniaIrvineCA 92697USA

A simple change of light source might prove what is needed for high-resolution label-free mapping of thin biological samples.

关键词： resolution visible coherent

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2019年第2期34卷 119-134页

作者： Mariia Novikova Yulan Zhang eric o. Freed Ke Peng Virus-Cell Interaction Section HIV Dynamics and Replication Program Center for Cancer Research National Cancer Institute Frederick MD 21702 USA State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

Human immunodeficiency virus-1 capsid(HIV-1 CA) is involved in different stages of the viral replication cycle. During virion assembly, CA drives the formation of the hexameric lattice in immature viral particles, while in mature virions CA monomers assemble in cone-shaped cores surrounding the viral RNA genome and associated proteins. In addition to its functions in late stages of the viral replication cycle, CA plays key roles in a number of processes during early phases of HIV-1 infection including trafficking, uncoating, recognition by host cellular proteins and nuclear import of the viral preintegration complex. As a result of efficient cooperation of CA with other viral and cellular proteins, integration of the viral genetic material into the host genome, which is an essential step for productive viral infection, successfully occurs. In this review, we will summarize available data on CA functions in HIV-1 replication, describing in detail its roles in late and early phases of the viral replication cycle.

关键词： Human immunodeficiency virus-1 (HIV-1) Capsid (CA) Assembly Post entry Uncoating and nuclear import Inhibitor

High efficiency GHz laser processing with long bursts

在线全文

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2023年第1期5卷 202-210页

作者： eric Audouard eric Mottay Amplitude PessacFrance

Bursts of GHz repetition rate pulses involve more ablation mechanisms than single femtosecond *** ablation by GHz laser pulses is a multi-step process,consisting of a first thermal incubation phase,followed by a highly efficient ablation *** ablation therefore combines thermal and non-thermal ablation *** an optimal choice of the burst duration,the ablation efficiency can be highly *** bursts,comprising tens of pulses to hundreds of pulses,are needed to take full advantage of the increase in ablation efficiency.

关键词： femtosecond laser temporal pulses shaping GHz bursts femtosecond processing

3D microfluidic gradient generator for combination antimicrobial susceptibility testing

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 229-242页

作者： eric Sweet Brenda Yang Joshua Chen Reed Vickerman Yujui Lin Alison long eric Jacobs Tinglin Wu Camille Mercier Ryan Jew Yash Attal Siyang Liu Andrew Chang Liwei Lin Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA Berkeley Sensor and Actuator Center BerkeleyCA 94720USA Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA

Microfluidic concentration gradient generators(µ-CGGs)have been utilized to identify optimal drug compositions through antimicrobial susceptibility testing(AST)for the treatment of antimicrobial-resistant(AMR)***µ-CGGs fabricated via photolithography-based micromachining processes,however,are fundamentally limited to two-dimensional fluidic routing,such that only two distinct antimicrobial drugs can be tested at *** work addresses this limitation by employing Multijet-3D-printed microchannel networks capable of fluidic routing in three dimensions to generate symmetric multidrug concentration *** three-fluid gradient generation characteristics of the fabricated 3Dµ-CGG prototype were quantified through both theoretical simulations and experimental ***,the antimicrobial effects of three highly clinically relevant antibiotic drugs,tetracycline,ciprofloxacin,and amikacin,were evaluated via experimental single-antibiotic minimum inhibitory concentration(MIC)and pairwise and three-way antibiotic combination drug screening(CDS)studies against model antibiotic-resistant Escherichia coli *** such,this 3Dµ-CGG platform has great potential to enable expedited combination AST screening for various biomedical and diagnostic applications.

关键词： gradient testing fluid

Infrared chemical imaging through non-degenerate two-photon absorption in silicon-based cameras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2020年第1期9卷 813-822页

作者： David Knez Adam M.Hanninen Richard C.Prince eric o.Potma Dmitry A.Fishman Department of Chemistry University of CaliforniaIrvineCA 92697USA Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA

Chemical imaging based on mid-infrared(MIR)spectroscopic contrast is an important technique with a myriad of applications,including biomedical imaging and environmental *** MIR cameras,however,lack performance and are much less affordable than mature Si-based devices,which operate in the visible and nearinfrared ***,we demonstrate fast MIR chemical imaging through non-degenerate two-photon absorption(NTA)in a standard Si-based charge-coupled device(CCD).We show that wide-field MIR images can be obtained at 100 ms exposure times using picosecond pulse energies of only a few femtojoules per pixel through NTA directly on the CCD *** this on-chip approach does not rely on phase matching,it is alignment-free and does not necessitate complex postprocessing of the *** emphasize the utility of this technique through chemically selective MIR imaging of polymers and biological samples,including MIR videos of moving targets,physical processes and live nematodes.

关键词： absorption Infrared chemical