Stem cell treatments for oropharyngeal dysphagia:Rationale,benefits,and challenges
作者机构：David Geffen School of MedicineUniversity of California-Los AngelesLos AngelesCA 90095United States Department of OtolaryngologyYale School of MedicineNew HavenCT 06511United States Department of Head and Neck SurgeryDavid Geffen School of MedicineUniversity of California-Los AngelesLos AngelesCA 90095United States Greater Los Angeles VA Healthcare SystemLos AngelesCA 90073United States
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2020年第12卷第9期
页 面：1001-1012页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
主 题：Dysphagia Xerostomia Hemiglossectomy Stem cells Myoblasts Mesenchymal stem cells
摘 要：Dysphagia,defined as difficulty swallowing,is a common symptom negatively impacting millions of adults *** prevalence ranges from 14 to 33 percent in those over age 65 to over 70 percent in a nursing home *** elderly,those with neurodegenerative diseases,head and neck cancer patients,and those with autoimmune conditions such as Sjögren s syndrome are disproportionately *** dysphagia refers specifically to difficulty in initiating a swallow due to dysfunction at or above the upper esophageal sphincter,and represents a large proportion of dysphagia *** treatments are limited and are often *** cell therapy is a new and novel advancement that may fill a much-needed role in our treatment ***,we review the current literature regarding stem cell treatments for oropharyngeal *** discussed include tissue regeneration advancements as a whole and translation of these principles into research surrounding tongue dysfunction,xerostomia,cricopharyngeal dysfunction,and finally an overview of the challenges and future directions for *** this field of study remains in its early stages,initial promising results show potential for the use of stem cell-based therapies to treat oropharyngeal dysphagia and warrant further research.
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