Complement factor P: promoting the antibacterial activity of natural killer cells

作     者：Xiaoxuan Zhuang Eric O Long 

作者机构：Laboratory of ImmunogeneticsNational Institute of Allergy and Infectious DiseasesNIHRockvilleMDUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2017年第14卷第10期

页      面：797-799页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：by a grant from the Intramural Research Program of the National Institutes of Health National Institute of Allergy and Infectious Diseases 

主　　题：killer al. cytotoxicity 

摘      要：Natural cytotoxicity receptors(NCRs)are expressed on natural killer(NK)cells and other subsets of innate lymphoid cells(ILC).Three NCRs,NKp30,NKp44 and NKp46,are expressed on human NK cells.1 NKp46 is the only NCR shared by primates and rodents,suggesting an essential role for this receptor during evolution.2 While cellular ligands for NKp30 and NKp44 have been identified,a well-characterized non-microbial ligand for NKp46 is still ***,in a recent paper in Science Immunology,Narni-Mancinelli et al.3 reported the identification of complement factor P(CFP,also known as properdin)as a ligand of NKp46.