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ESWL for difficult bile duct stones:A 15-year single centre experience

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World Journal of Gastroenterology 2010年第33期16卷 4159-4163页

作者： Rosangela Muratori Francesco Azzaroli Federica Buonfiglioli Flavio Alessandrelli Paolo Cecinato Giuseppe Mazzella enrico roda Department of Digestive Diseases and Internal Medicine S.Orsola-Malpighi HospitalUniversity of Bologna

AIM:To evaluate the efficacy of extracorporeal shock wave lithotripsy(ESWL)for the management of refractory bile duct cholelithiasis in a third level referral ***:The clinical records of all patients treated with a second generation electromagnetic lithotripter (Lithostar Plus,SIEMENS)from October 1990 to April 2005 were *** patients were monitored during the procedure and antibiotics were administered in case of ***χ 2 test and logistic regression analysis were performed as ***:Two hundred and fourteen patients(102 males,112 females;mean age 74.8±0.84 years-single stone 97,multiple stones 117)underwent *** mean number of sessions and shock waves were 3.5 ±0.13 and 3477.06±66.17,*** maximum stone size was 5 *** stone clearance was achieved in 192(89.7%)*** the remain-ing patients 15 required surgery,2 a palliative stent and in 5 patients stone fragmentation led to effective bile drainage with clinical resolution despite incomplete ***,sex and stone characteristics were not related to treatment *** complications occurred in two patients(haemobilia and rectal bleeding) and minor complications in 25(3 vomiting,22 arrhythmias).No procedure-related deaths ***:ESWL is a safe and effective technique for clearance of refractory bile duct stones.

关键词： Difficult bile duct stones Extracorporeal shock wave lithotripsy

G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence

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World Journal of Gastroenterology 2009年第43期15卷 5449-5454页

作者： Francesca Lodato Francesco Azzaroli Maria Rosa Tamè Maria Di Girolamo Federica Buonfiglioli Natalia Mazzella Paolo Cecinato enrico roda Giuseppe Mazzella Department of Digestive Diseases and Internal Medicine University of BolognaBologna 40138Italy

AIM:To evaluate the efficacy of granulocyte colony stimulating factors(G-CSF)in liver transplanted patients with hepatitis C(HCV)recurrence and Pegylated-IFN α-2b induced neutropenia,and to evaluate the impact of G-CSF administration on virological response. METHODS:Sixty-eight patients undergoing antiviral treatment for post-liver transplantation(OLT)HCV recurrence were *** patients developing neutropenia received G-CSF. RESULTS:Twenty three(34%)received *** neutrophil count at the onset of neutropenia was 700/mmc(range 400-750/mmc);after 1 mo of G-CSF it increased to 1210/mmc(range 300-5590/mmc) (P<0.0001).Three patients did not respond to G-CSF. Treatment duration was similar in neutropenic and non-neutropenic *** differences in the rate of discontinuation,infections or virological response were observed between the two groups.G-CSF was protective for the onset of de novo autoimmune hepatitis(P<0.003). CONCLUSION:G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasingneutrophil count,prolonging treatment and leading to sustained virological response(SVR)rates comparable to non-neutropenic *** prevents the occurrence of de novo autoimmune hepatitis.

关键词：丙型肝炎病毒中性粒细胞干扰素α 聚乙二醇 CSF 肝移植粒细胞集落刺激因子患者

Therapeutic effectiveness of echo-guided percutaneous radiofrequency ablation therapy with a LeVeen needle electrode in hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第7期12卷 1098-1104页

作者： Luigi Solmi Giovanni Nigro enrico roda Gastroenterological Unit Polyclinic Hospital Sant'Orsola-MalpighiUniversity School of MedicineBolognaItaly

瞄准：在在肝脏硬化症的病人获得肝细胞癌(HCC ) 的坏死调查射频脱离(RFA ) 的结果并且在与 HCC 的复发和对待的病人的幸存的关系估计 RFA 的结果。方法：有 63 HCC 的 56 个连续肝脏硬化症的病人与在 2000 年 5 月和 2004 年 5 月之间... 详细信息

瞄准：在在肝脏硬化症的病人获得肝细胞癌(HCC ) 的坏死调查射频脱离(RFA ) 的结果并且在与 HCC 的复发和对待的病人的幸存的关系估计 RFA 的结果。方法：有 63 HCC 的 56 个连续肝脏硬化症的病人与在 2000 年 5 月和 2004 年 5 月之间的 RFA 被对待。HCC 的直径从 1 厘米到 5 厘米(平均数 2.8 厘米) 。在所有情况中， RFA 用可扩充的针电极(LeVeen 针) 在超声指导下面与经皮的途径被执行。治疗功效和复发与双阶段的螺线被评估计算断层摄影术(CT ) 。结果：在单个或多重的治疗以后的完全的坏死在 96.8% 被完成(61/63 ) 肿瘤。我们在 32.3 个月的吝啬的后续期间在 23 个病人(41%) 在完全的坏死以后观察了复发。复发在 2 个病人(8.6%) 并且在在 21 的不同片断是本地的(91.4%) 。主要复杂并发症发生在 3 个病人(4%) 。在后续时期期间， 32 (57.1%) 病人们死了；15 由于 HCC 的前进， 11 从肝失败， 3 从食道的静脉曲张流血并且 3 从不与肝有关的原因疾病。结论：有 LeVeen 针的 RFA 是为在肝脏硬化症的病人的 HCC<5 厘米的有效、安全的治疗。这治疗多远影响病人的幸存率，还得被建立。建立治疗在不同片断阻止复发变得重要，例如干扰素治疗。

关键词：治疗效果射频消融肝细胞癌并发症

Inflammatory bowel disease: Moving toward a stem cell-based therapy

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World Journal of Gastroenterology 2008年第29期14卷 4616-4626页

作者： Giacomo Lanzoni Giulia roda Andrea Belluzzi enrico roda Gian Paolo Bagnara Department of Histology Embryology and Applied Biology University of BolognaBologna 40126 Italy Gastroenterology Unit University of Bologna S.Orsola HospitalBologna 40126 Italy Department of Histology Embryology and Applied Biology University of BolognaBologna 40126 Italy "Giorgio Prodi" Interdepartmental Research Centre for Cancer Research University of Bologna Bologna 40138 Italy

The incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD), are rising in western countries. The modern hygienic lifestyle is probably at the root of a disease where, in genetically susceptible hosts, the intestinal commensal flora triggers dysregulated immune and inflammatory responses. Current therapies ranging from anti-inflammatory drugs to immunosuppressive regimens, remain inadequate. Advances in our understanding of the cell populations involved in the pathogenetic processes and recent findings on the regenerative, trophic and immunoregulatory potential of stem cells open new paths in IBD therapy. Hematopoietic and mesenchymal stem cells are catalyzing the attention of IBD investigators. This review highlights the pivotal fi ndings for stem cell-based approaches to IBD therapy and collects the encouraging results coming in from clinical trials.

关键词：间叶干细胞造血干细胞肠炎治疗方法

A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon

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World Journal of Gastroenterology 2007年第7期13卷 1079-1084页

作者： Aldo roda Patrizia Simoni Maria Magliulo Paolo Nanni Mario Baraldini Giulia roda enrico roda Department of Pharmaceutical Sciences University of Bologna Via Belmeloro 6 Bologna 40126 Italy Department of Internal Medicine and Gastroenterology University of Bologna via Massarenti 9 Bologna 40126 Italy

AIM: To develop a new formulation with hydroxy propyl methyl cellulose and Shellac coating for extended and selective delivery of butyrate in the ileo-caecal region and colon. METHODS: One-gram sodium butyrate coated tablets containing 13C-butyrate were orally administered to 12 healthy subjects and 12 Crohn's disease patients and the rate of 13C-butyrate absorption was evaluated by 13CO2 breath test analysis for eight hours. Tauroursodeoxycholic acid (500 mg) was co-administered as a biomarker of oro-ileal transit time to determine also the site of release and absorption of butyrate by the time of its serum maximum concentration. RESULTS: The coated formulation delayed the 13C-butyrate release by 2-3 h with respect to the uncoated tablets. Sodium butyrate was delivered in the intestine of all subjects and a more variable transit time was found in Crohn's disease patients than in healthy subjects. The variability of the peak 13CO2 in the kinetic release of butyrate was explained by the inter-subject variability in transit time. However, the coating chosen ensured an efficient release of the active compound even in patients with a short transit time. CONCLUSION: Simultaneous evaluation of breath 13CO2 and tauroursodeoxycholic acid concentration- time curves has shown that the new oral formulation consistently releases sodium butyrate in the ileo-cecal region and colon both in healthy subjects and Crohn's disease patients with variable intestinal transit time. This formulation may be of therapeutic value in inflammatory bowel disease patients due to the appropriate release of the active compound.

关键词：公式化列方程式丁酸钠盲肠结肠

A new iron free treatment with oral fish cartilage polysaccharide for iron deficiency chronic anemia in inflammatory bowel diseases:A pilot study

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World Journal of Gastroenterology 2007年第10期13卷 1575-1578页

作者： Andrea Belluzzi Giulia roda Francesca Tonon Antonio Soleti Alessandra Caponi Anna Tuci Aldo roda enrico roda enrico roda Gastroenterology UnitUniversity of BolognaS.Orsola HospitalVia Massarenti

AIM:To investigate the effect of a new oral preparation,highly concentrated in fish cartilage,in a group of inflammatory bowel diseases(IBD)patients with chronic iron deficient ***:In an open label pilot study,we supple-mented a group of 25 patients(11 with Crohn's disease and 14 with ulcerative colitis)in stable clinical conditions and chronic anemia with a food supplement which does not contain iron but contains a standardized fraction of fish cartilage glycosaminoglycans and a mixture of antioxidants(Captafer Medestea,Turin,Italy).Patients received 500 mg,twice a day during meals,for at least 4 *** were suggested to maintain their alimentary *** time 0 and after 2 and 4 mo,emocrome,sideremia and ferritin were *** data were analyzed with Student's t ***:Three patients relapsed during the study(2 in the 3rd mo,1 in the 4th mo),two patients were lost to follow up and two patients dropped out(1 for orticaria,1 for gastric burning).Of the remaining 18 patients,levels of serum iron started to rapidly increase within the 2nd mo of treatment,P < 0.05),whereas serum ferritin and hemoglobin needed a longer period to significantly improve their serum levels(mo 4)P < *** product was safe,easy to administer and well tolerated by ***:These data suggest a potential new treatment for IBD patients with iron deficiency chronic anemia and warrant further larger controlled studies.

关键词：炎症性肠病缺铁性慢性贫血鱼类软骨多糖口服无铁制剂治疗

Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot enrico Panettieri Antonio Cosculluela Marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

High-speed tracked vehicle model order reduction for static and dynamic simulations

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Defence Technology（防务技术） 2024年第8期38卷 89-110页

作者： Luca Dimauro Simone Venturini Antonio Tota enrico Galvagno Mauro Velardocchia Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli Abruzzi2410129TorinoItaly

In this paper, a model order reduction strategy is adopted for the static and dynamic behaviour simulation of a high-speed tracked vehicle. The total number of degree of freedom of the structure is condensed through a selection of interface degrees of freedom and significant global mode shapes, for an approximated description of vehicle dynamic behaviour. The methodology is implemented in a customised open-source software to reduce the computational efforts. The modelled tracked vehicle includes the sprung mass, the unsprung masses, connected by means of torsional bars, and all the track assemblies, composing the track chain. The proposed research activity presents a comprehensive investigation of the influence of the track chain, combined with longitudinal vehicle speed, on statics and vehicle dynamics, focusing on vertical dynamics. The vehicle response has been investigated both in frequency and time domain. In this last case road-wheel displacements are assumed as inputs for the model, under different working conditions, hence considering several road profiles with different amplitudes and characteristic excitation frequencies. Simulation results have proven a high fidelity in model order reduction approach and a significant contribution of the track chain in the global dynamic behaviour of the tracked vehicle.

关键词： Tracked vehicle dynamics Rubber characteristics Component mode synthesis Modal analysis Open-source

Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough:A comparison between two different daily doses of lansoprazole

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World Journal of Gastroenterology 2006年第1期12卷 82-88页

作者： Fabio Baldi Roberta Cappiello Carlotta Cavoli Stefania Ghersi Francesco Torresan enrico roda Department of Gastroenterology Metabolic and Infectious DiseasesS.OrsolaMalpighi HospitalBolognaItaly

瞄准：为了比较 lansoprazole 的二不同一日量，给 12 个星期并且到估计角色胃肠(官方补给) 是的调查为选择病人的标准。方法：从 45 ，病人们为 unexplained 提交了长期的坚持的咳嗽， 36 有至少一官方补给的调查(内视镜检查法，食道的... 详细信息

瞄准：为了比较 lansoprazole 的二不同一日量，给 12 个星期并且到估计角色胃肠(官方补给) 是的调查为选择病人的标准。方法：从 45 ，病人们为 unexplained 提交了长期的坚持的咳嗽， 36 有至少一官方补给的调查(内视镜检查法，食道的 pH-metry 和质子的4星期的试用抽的 24-h 禁止者( PPI )治疗)积极并且随机被分配收到 30 mg lansoprazole o.d 或 30 mg 为 12 个星期的 lansoprazole b.i.d 。症状在 PPI 测试(访问 2 ) 以后并且在 12 星期的 lansoprazole 治疗经期(访问 3 ) 以后在基线(访问 1 ) 被评估。结果：35 个病人完成了学习协议。报导的 21 个病人(60.0%) 没有二个治疗组之间的差别从他们的咳嗽完成地势(58.8% 和 61.1% 没在 30 mg lansoprazole 和 60 个 mg lansoprazole 组有咳嗽，分别地) 。在治疗的结束从他们的咳嗽有完全的地势的超过 80% 病人显示出积极回答到 PPI 测试。结论：12 星期甚至在标准一日量的 lansoprazole 治疗，在有长期的坚持的咳嗽的病人是有效的。对起始的 PPI 测试的积极回答似乎是为选择对治疗作出回应的病人的最好的标准。

关键词：抑制剂胃疾病食管疾病慢性咳嗽羊毛二烯