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The paradox role of cytotoxic T-lymphocytes in NAFLD-associated hepatocellular carcinoma

Hepatobiliary Surgery and Nutrition 2021年第5期10卷 705-707页

作者： emanuele albano Salvatore Sutti Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases University of Eastern PiedmontNovaraItaly

Nonalcoholic fatty liver disease(NAFLD)is already the fastest growing cause of hepatocellular carcinoma(HCC)in several countries(1).Despite the incidence of NAFLD-related HCC is still lower than that of HCCs associated to viral infections,its prevalence is expected to increase in the next years concomitantly with the growing diffusion of overweight and obesity(1).Current view sees chronic hepatic inflammation as the driving force in the evolution of NAFLD to liver fibrosis/cirrhosis as well as in the development of *** this setting,available evidence indicates that beside innate immunity also adaptive immune responses play an important role in supporting hepatic inflammation(2).

关键词： NAFLD inflammation hepatocellular

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Molecular mechanisms of liver preconditioning

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World Journal of Gastroenterology 2010年第48期16卷 6058-6067页

作者： Elisa Alchera Caterina Dal Ponte Chiara Imarisio emanuele albano Rita Carini Department of Medical Sciences University of East Piedmont "A. Avogadro"

Ischemia/reperfusion (I/R) injury still represents an important cause of morbidity following hepatic surgery and limits the use of marginal livers in hepatic transplantation. Transient blood flow interruption followed by reperfusion protects tissues against damage induced by subsequent I/R. This process known as ischemic pre-conditioning (IP) depends upon intrinsic cytoprotective systems whose activation can inhibit the progression of irreversible tissue damage. Compared to other organs,liver IP has additional features as it reduces inflammation and promotes hepatic regeneration. Our present understanding of the molecular mechanisms involved in liver IP is still largely incomplete. Experimental studies have shown that the protective effects of liver IP are triggered by the release of adenosine and nitric oxide and the subsequent activation of signal networks involving protein kinases such as phosphatidylinositol 3-kinase,protein kinase C δ/ε and p38 MAP kinase,and transcription factors such as signal transducer and activator of transcription 3,nuclear factor-κB and hypoxia-inducible factor 1. This article offers an overview of the molecular events underlying the preconditioning effects in the liver and points to the possibility of developing pharmacological approaches aimed at activating the intrinsic protective systems in patients undergoing liver surgery.

关键词： Apoptosis Hepatocyte Hypoxia Ischemia/ reperfusion Liver surgery Necrosis Pharmacological preconditioning Preconditioning Survival pathways

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Phlebotomy improves histology in chronic hepatitis C males with mild iron overload

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World Journal of Gastroenterology 2010年第5期16卷 596-602页

作者： Massimo Sartori Silvano Andorno Angelo Rossini Renzo Boldorini Cristina Bozzola Stefania Carmagnola Mario Del Piano emanuele albano Gastroenterology Unit Azienda Ospedaliero-Universitaria Maggiore della CaritàCorso Mazzini1828100 NovaraItaly Hepatology Unit A.O.Spedali Civili25100 BresciaItaly Department of Medical Sciences University of East Piedmont"Amedeo Avogadro" 28100 NovaraItaly

AIM:To investigate the usefulness of mild iron depletion and the factors predictive for histological improvement following phlebotomy in Caucasians with chronic hepatitis C(CHC). METHODS:We investigated 28 CHC Caucasians with persistently elevated serum aminotransferase levels and non responders to,or unsuitable for,antiviral therapy who underwent mild iron depletion(ferritin≤70 ng/mL) by long-term *** improvement,as defined by at least one point reduction in the staging score or,in case of unchanged stage,as at least two points reduction in the grading score(Knodell),was evaluated in two subsequent liver biopsies(before and at the end of phlebotomy,48±16 mo apart).RESULTS:Phlebotomy showed an excellent safety *** improvement occurred in 12/28 phlebotomized *** males responded to *** univariate logistic analysis alcohol intake(P=0.034),high histological grading(P=0.01) and high hepatic iron concentration(HIC)(P=0.04) before treatment were associated with histological *** logistic analysis showed that in males high HIC was the only predictor of histological improvement following phlebotomy(OR=1.41, 95%CI:1.03-1.94,P=0.031).Accordingly,12 out of 17(70%)patients with HIC≥20μmol/g showed histological improvements at the second biopsy. CONCLUSION:Male CHC Caucasian non-responders to antiviral therapy with low-grade iron overload can benefit from mild iron depletion by long-term phlebotomy.

关键词： Hepatic iron Hepatitis C Oxidative stress Aminotransferases

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Is there a role for adaptive immunity in nonalcoholic steatohepatitis?

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World Journal of Hepatology 2015年第13期7卷 1725-1729页

作者： Salvatore Sutti Aastha Jindal Stefania Bruzzì Irene Locatelli Cristina Bozzola emanuele albano Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases University "Amedeo Avogadro" of East Piedmont

The growing diffusion of nonalcoholic fatty liver disease(NAFLD) is a consequence of the worldwide increase in the prevalence of *** stress is widely recognized to play a pivotal role in NAFLD evolution to nonalcoholic steatohepatitis(NASH).Here we review recent evidence suggesting that oxidative stress-derived antigens originating within fatty livers stimulate both humoral and cellular adaptive immune responses and the possible mechanisms involved in sustaining hepatic inflammation in NASH.

关键词： Liver Adaptive immunity Nonalcoholicsteatohepatitis Hepatic inflammation Nonalcoholicfatty liver disease

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