The paradox role of cytotoxic T-lymphocytes in NAFLD-associated hepatocellular carcinoma

作     者：Emanuele Albano Salvatore Sutti 

作者机构：Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune DiseasesUniversity of Eastern PiedmontNovaraItaly 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2021年第10卷第5期

页      面：705-707页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The research was supported by the University of Eastern Piedmont(grant FAR 2019) Fondazione Cariplo Milan,Italy(grant 2017/0535) 

主　　题：NAFLD inflammation hepatocellular 

摘      要：Nonalcoholic fatty liver disease(NAFLD)is already the fastest growing cause of hepatocellular carcinoma(HCC)in several countries(1).Despite the incidence of NAFLD-related HCC is still lower than that of HCCs associated to viral infections,its prevalence is expected to increase in the next years concomitantly with the growing diffusion of overweight and obesity(1).Current view sees chronic hepatic inflammation as the driving force in the evolution of NAFLD to liver fibrosis/cirrhosis as well as in the development of *** this setting,available evidence indicates that beside innate immunity also adaptive immune responses play an important role in supporting hepatic inflammation(2).