Is there a role for adaptive immunity in nonalcoholic steatohepatitis?

作     者：Salvatore Sutti Aastha Jindal Stefania Bruzzì Irene Locatelli Cristina Bozzola Emanuele Albano 

作者机构：Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune DiseasesUniversity "Amedeo Avogadro" of East Piedmont 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第13期

页      面：1725-1729页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Liver Adaptive immunity Nonalcoholicsteatohepatitis Hepatic inflammation Nonalcoholicfatty liver disease 

摘      要：The growing diffusion of nonalcoholic fatty liver disease(NAFLD) is a consequence of the worldwide increase in the prevalence of *** stress is widely recognized to play a pivotal role in NAFLD evolution to nonalcoholic steatohepatitis(NASH).Here we review recent evidence suggesting that oxidative stress-derived antigens originating within fatty livers stimulate both humoral and cellular adaptive immune responses and the possible mechanisms involved in sustaining hepatic inflammation in NASH.