Phlebotomy improves histology in chronic hepatitis C males with mild iron overload

作     者：Massimo Sartori Silvano Andorno Angelo Rossini Renzo Boldorini Cristina Bozzola Stefania Carmagnola Mario Del Piano Emanuele Albano 

作者机构：Gastroenterology UnitAzienda Ospedaliero-Universitaria Maggiore della CaritàCorso Mazzini1828100 NovaraItaly Hepatology UnitA.O.Spedali Civili25100 BresciaItaly Department of Medical Sciences University of East Piedmont"Amedeo Avogadro"28100 NovaraItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第5期

页      面：596-602页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Hepatic iron Hepatitis C Oxidative stress Aminotransferases 

摘      要：AIM:To investigate the usefulness of mild iron depletion and the factors predictive for histological improvement following phlebotomy in Caucasians with chronic hepatitis C(CHC). METHODS:We investigated 28 CHC Caucasians with persistently elevated serum aminotransferase levels and non responders to,or unsuitable for,antiviral therapy who underwent mild iron depletion(ferritin≤70 ng/mL) by long-term *** improvement,as defined by at least one point reduction in the staging score or,in case of unchanged stage,as at least two points reduction in the grading score(Knodell),was evaluated in two subsequent liver biopsies(before and at the end of phlebotomy,48±16 mo apart).RESULTS:Phlebotomy showed an excellent safety *** improvement occurred in 12/28 phlebotomized *** males responded to *** univariate logistic analysis alcohol intake(P=0.034),high histological grading(P=0.01) and high hepatic iron concentration(HIC)(P=0.04) before treatment were associated with histological *** logistic analysis showed that in males high HIC was the only predictor of histological improvement following phlebotomy(OR=1.41, 95%CI:1.03-1.94,P=0.031).Accordingly,12 out of 17(70%)patients with HIC≥20μmol/g showed histological improvements at the second biopsy. CONCLUSION:Male CHC Caucasian non-responders to antiviral therapy with low-grade iron overload can benefit from mild iron depletion by long-term phlebotomy.