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Treatment of hemorrhoids: A survey of surgical practice in Australia and New Zealand

World Journal of Clinical Cases 2019年第22期7卷 3742-3750页

作者： George E Fowler Javariah siddiqui Assad Zahid Christopher John Young Department of Colorectal Surgery Royal Devon and Exeter NHS Foundation TrustExeter EX25DWUnited Kingdom Department of Colorectal Surgery Royal Prince Alfred HospitalNewtown 2042NSWAustralia

BACKGROUND Hemorrhoidal disease is the most common anorectal *** can be classified as external or internal,according to their relation to the dentate *** hemorrhoids originate below the dentate line and are managed conservatively unless the patient cannot keep the perianal region clean,or they cause significant *** hemorrhoids originate above the dentate line and can be managed according to the graded degree of prolapse,as described by ***,low-grade internal hemorrhoids are effectively treated conservatively,by non-operative measures,while high-grade internal hemorrhoids warrant procedural *** To determine the application of clinical practice guidelines for the current management of hemorrhoids and colorectal surgeon consensus in Australia and New *** An online survey was distributed to 206 colorectal surgeons in Australia and New Zealand using 17 guideline-based hypothetical clinical *** There were 82 respondents(40%)to 17 guideline-based ***(53%)reached consensus,of which only 1(6%)disagreed with the *** was based on low quality evidence for the management of acutely thrombosed external *** were 8 scenarios which showed community equipoise(47%)and they were equally divided for agreeing or disagreeing with the *** topics were based on low and moderate levels of *** included the initial management of grade I internal hemorrhoids,grade III internal hemorrhoids when initial management had failed and the patient had recognised risks factors for septic complications;and finally,the decision-making when considering patient preferences,including a prompt return to work,or minimal post-operative *** Although there are areas of consensus in the management of hemorrhoids,there are many areas of community equipoise which would benefit from further research.

关键词： Hemorrhoids Clinical practice guidelines Survey Consensus

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A two step facile synthesis of new steroidal linear and angular pyranones having anti-mycobacterial activity

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Chinese Chemical Letters 2009年第2期20卷 153-157页

作者： Shams-uz-zaman Tabassum siddiqui Mohd.Gulfam Alam Najmul Islam Department of Chemistry(Steroid Lab) Aligarh Muslim University Department of Biochemistry Faculty of medicineJ.N.Medical College

Title compounds 2′,2′-dimethylcholesta-2,4-dien[3,2-b]-pyran-4′-one （3）, 2′,2′-dimethyl-3β-substituted cholesta-4,6-dien[7,6- b]-pyran-4′-one （6a,b） and （6c） were prepared by the cyclization of 2-acetylcholesta-2,4-dien-3-ol （2）, 6-acetyl-3β-substituted- cholesta-4,6-dien-7-ol （Sa,b） and （5c） respectively, with pyrrolidine, dry benzene and dry acetone using Dean Stark separator through conventional heating. Furthermore, compounds were also found to be active against Mycobacterium tuberculosis.

关键词： Steroidal linear and angular pyranones Acetyl hydroxy derivative of steroids Pyrrolidine Acetyl chloride Dean Stark separator Anti-mycobacterial activity

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India at crossroads for energy

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Geoscience Frontiers 2021年第6期12卷 356-360页

作者： Mu Ramkumar M.Santosh Manoj J.Mathew Numair A.siddiqui Department of Geology Periyar UniversitySalem636011India School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing100083China Department of Earth Science University of AdelaideAdelaideSAAustralia Shale Gas Research Group Institute of Hydrocarbon RecoveryUniversiti Teknologi PETRONAS32610Seri IskandarMalaysia Department of Geosciences Universiti Teknologi PetronasTronohMalaysia

As one of the fastest growing economies and further larger consumer of energy in the world, there has been a paradigm shift in India’s energy demand. Here we evaluate the growth of Indian economy its, diversification of agriculture-based economy to industrial production, service and digital-technology based economy and deepening of income sources, although the dependence on foreign sources for energy demands has not markedly *** situation has placed India at the crossroads for energy sufficiency, especially under the highly fluid and changing geopolitical, strategic, environmental and economic scenarios of the World order. We attempt to understand the issue from geological perspective and address some of the impediments.

关键词： Economy Energy sources Technology Geological impediments India

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Early Cenozoic rapid flight enigma of the Indian subcontinent resolved:Roles of topographic top loading and subcrustal erosion

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Geoscience Frontiers 2017年第1期8卷 15-23页

作者： Muthuvairavasamy Ramkumar David Menier Manoj Mathew M.Santosh Numair A.siddiqui Department of Geology Periyar UniversitySalem 636011India South East Asia Carbonate Research Laboratory(SEACaRL) Universiti Teknologi Petronas31750 TronohMalaysia GMGL UMR CNRS 6538 Universite de Bretagne Sud56017 Vannes CedexFrance Department of Earth Sciences University of AdelaideSA 5005Australia School of Earth Sciences and Resources China University of Ceosciences Beijing29 Xueyuan RoadBeijing 100083China Department of Geosciences Universiti Teknologi Petronas31750 TronohMalaysia

Intrinsic magmatic processes are considered as critical operators of plate movements. Here we demonstrate the role of extrinsic processes consequent to intrinsic processes as a catalyst for anomalous rapid plate movement. The rapid and accelerated flight of the Indian subcontinent since Deccan volca- nism until its collision with Eurasia remains as one of the geological conundrums. Data on seismic to- mography, peninsular geomorphology and inferences on continuum of subcrustal structures are utilized to address this enigma. We propose geomorphic isostasy as the mechanism that has driven this fastest drift ever recorded in geological history. It was initiated by sudden instability after the Deccan volcanism and resultant extensive accumulation of lava pile over continental lithosphere of northern India, northern-eastern tilt due to crustal thickness heterogeneity and subcrustal thermal stratification. The drift was sustained by Carlsberg and Central Indian ridge-push until collision and sediment top loading at northeast thenceforth. These inferences and geomorphic isostasy as a catalytic mechanism necessitate variability of drift rates as integral inputs for any continental scale modeling.

关键词： Geomorphic isostasy Mantle plume Continental drift Plate reorganization India

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Development of stability-preserving time-limited model reduction framework for 2-D and 1-D models with error bound

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Control Theory and Technology 2022年第3期20卷 371-381页

作者： Muhammad Imran Syeda Hira Ambreen Syed Nooh Hamdani Muhammad Imran Muhammad Ejaz Naveed Maria siddiqui Department of Electrical Engineering Military College of Signals(MCS)National University of Sciences and Technology(NUST)Islamabad43000Pakistan Department of Electrical Engineering Sir Syed(Center For Advanced Studies)Institute of Technology(SSCASE)Islamabad43000Pakistan College of Science and Humanities Rumah Majmaah UniversityRumahKingdom of Saudi Arabia

Due to their complex structure,2-D models are challenging to work with;additionally,simulation,analysis,design,and control get increasingly difficult as the order of the model ***,in particular time intervals,Gawronski and Juang’s time-limited model reduction schemes produce an unstable reduced-order model for the 2-D and 1-D *** revealed some stability preservation solutions to address this key flaw which ensure the stability of 1-D reduced-order systems;nevertheless,these strategies result in large approximation ***,to the best of the authors’knowledge,there is no literature available for the stability preserving time-limited-interval Gramian-based model reduction framework for the 2-D discrete-time *** this article,2-D models are decomposed into two separate sub-models(i.e.,two cascaded 1-D models)using the condition of minimal *** reduction procedures are conducted on these obtained two 1-D sub-models using limited-time *** suggested methodology works for both 2-D and 1-D ***,the suggested methodology gives the stability of the reduced model as well as a priori error-bound expressions for the 2-D and 1-D *** results and comparisons between existing and suggested methodologies are provided to demonstrate the effectiveness of the suggested methodology.

关键词： Model reduction Weighted Gramian Limited interval Gramian Minimal realization Approximation error Error bound

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Colorectal surgeon consensus with diverticulitis clinical practice guidelines

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World Journal of Gastrointestinal Surgery 2017年第11期9卷 224-232页

作者： Javariah siddiqui Assad Zahid Jonathan Hong Christopher John Young Discipline of Surgery University of Sydney Department of Colorectal Surgery Royal Prince Alfred Hospital

AIM To determine the application of clinical practice guidelines for the current management of diverticulitis and colorectal surgeon specialist consensus in Australia and New *** A survey was distributed to 205 colorectal surgeons in Australia and New Zealand, using 22 hypothetical clinical *** The response rate was 102(50%). For 19 guidelinebased scenarios, only 11(58%) reached consensus(defined as > 70% majority opinion) and agreed with guidelines; while 3(16%) reached consensus and did not agree with guidelines. The remaining 5(26%) scenarios showed community equipoise(defined as less than/equal to 70% majority opinion). These included diagnostic imaging where CT scan was contraindicated, management options in the failureof conservative therapy for complicated diverticulitis, surgical management of Hinchey grade 3, proximal extent of resection in sigmoid diverticulitis and use of oral mechanical bowel preparation and antibiotics for an elective colectomy. The consensus areas not agreeing with guidelines were management of simple diverticulitis, management following the failure of conservative therapy in uncomplicated diverticulitis and follow-up after an episode of complicated diverticulitis. Fifty-percent of rural/regional based surgeons would perform an urgent sigmoid colectomy in failed conservative therapy of diverticulitis compared to only 8% of surgeons city-based(Fisher's exact test P = 0.016). In right-sided complicated diverticulitis, a greater number of those in practice for more than ten years would perform an ileocecal resection and ileocolic anastomosis(79% vs 41%, P < 0.0001).CONCLUSION While there are areas of consensus in diverticulitis management, there are areas of community equipoise for future research, potentially in the form of RCTs.

关键词： Diverticulitis Clinical practice guidelines Consensus

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NLP-Based Subject with Emotions Joint Analytics for Epidemic Articles

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Computers, Materials & Continua 2022年第11期73卷 2985-3001页

作者： Woo Hyun Park Isma Farah siddiqui Dong Ryeol Shin Nawab Muhammad Faseeh Qureshi Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Korea Department of Software Engineering Mehran University of Engineering&TechnologyJamshoroPakistan Department of Computer Education Sungkyunkwan UniversitySeoul03063Korea

have been focused on addressing the Covid-19 pandemic;for example,governments have implemented countermeasures,such as quarantining,pushing vaccine shots to minimize local spread,investigating and analyzing the virus’characteristics,and conducting epidemiological investigations through patient management and ***,researchers worldwide require funding to achieve these ***,there is a need for documentation to investigate and trace disease ***,it is time consuming and resource intensive to work with documents comprising many types of unstructured ***,in this study,natural language processing technology is used to automatically classify these *** used statistical methods include data cleansing,query modification,sentiment analysis,and ***,owing to limitations with respect to the data,it is necessary to understand how to perform data analysis suitable for medical *** solve this problem,this study proposes a robust in-depth mixed with subject and emotion model comprising three *** first is a subject and non-linear emotional module,which extracts topics from the data and supplements them with emotional *** second is a subject with singular value decomposition in the emotion model,which is a dimensional decomposition module that uses subject analysis and an emotion *** third involves embedding with singular value decomposition using an emotion module,which is a dimensional decomposition method that uses emotion *** accuracy and other model measurements,such as the F1,area under the curve,and recall are evaluated based on an article on Middle East respiratory syndrome.A high F1 score of approximately 91%is *** proposed joint analysis method is expected to provide a better synergistic effect in the dataset.

关键词： Computational linguistic AI epidemic healthcare classification

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航空旅行轮椅设计,行动不便者的福音

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工业设计 2024年第4期 18-18页

作者： Amer siddiqui Ali Asgar Salim 不详

这是一种新型的航空旅行轮椅,可以帮助行动不便的乘客方便快速地登机和入座。一般来说,乘坐轮椅的乘客在登机后必须转移到飞机上的固定座位,这一过程复杂而艰难。使用该航空旅行轮椅后,这一流程将更加便利,行动不便的乘客可以在从登机... 详细信息

这是一种新型的航空旅行轮椅,可以帮助行动不便的乘客方便快速地登机和入座。一般来说,乘坐轮椅的乘客在登机后必须转移到飞机上的固定座位,这一过程复杂而艰难。使用该航空旅行轮椅后,这一流程将更加便利,行动不便的乘客可以在从登机口到抵达大厅的整个行程中不需要更换座位。

关键词：航空旅行登机口轮椅抵达乘客

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Dose-dependent effect of histamine on antibody generation in vivo

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 112-116页

作者： Tripathi T Shahid M Khan HM Khan RA siddiqui MU DePartment of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University

Objective:To delineate immunomodulatory role of histamine on antibody generation pr of ile in rabbit in the present dose-dependent histamine ***:The cohort comprised of three groups(Ⅲ,ⅣandⅤ),containing six rabbits each,and received subcutaneous histamine 50μg/kg×bis in die(b.i.d.),100μg/kg×*** 200μg/kg X b.i.d.,respectively for 10 days (starting from the 1st day).They were subsequently immunized on the 3rd day with intravenous injection of sheep blood cell(SRBC)(1×10 cells/mL).GroupⅡ(positive control)(n=6) received vehicle(sterile distilled water) and immunized at day 3 similarly while groupⅠ(negative control) (n=6) remained non-immunized and received only *** experimentations were performed in *** samples were collected on pre-immunization(pre-I)(day 0),as well as on days 7-,14-,21-,28- and 58- post-immunization(post-I).Immunological parameters[total immunoglobulins(Igs),IgM and IgG]were analyzed by enzyme linked immunosorbent assay (ELISA) ***:Histamine could influence a detectable antibody response to SRBC as early as day 7-post-I,which lasted until day 58- *** results were found statistically significant(P< 0.05).Conclusions:Our results provide evidence that histamine has a short-term effect on antibody generation(until its presence in the body),and the antibody generation titer in vivo were affected by the concentration of histamine.

关键词： Histamine Immumomodulation T-cell dependent antibody response Humoral immune response SRBC

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Massive ascites as a presenting manifestation of chronic lymphocytic leukemia

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World Journal of Gastroenterology 2008年第22期14卷 3594-3597页

作者： Neelam siddiqui Saeed Al-Amoudi Aamer Aleem Maha Arafah Layla Al-Gwaiz Department of Medicine College of Medicine King Khalid University Hospital King Saud University Riyadh Saudi Arabia Department of Pathology College of Medicine King Khalid University Hospital King Saud University Riyadh Saudi Arabia

Ascites is not an uncommon manifestation of certain solid tumors like gastrointestinal malignancies, ovarian cancer and breast cancer. However, it is unusual to encounter ascites in patients with hematological malignancies especially chronic leukemia. The patient described here presented with massive ascites and blood lymphocytosis. Further studies confirmed the diagnosis of chronic lymphocytic leukemia with ascites. The ascitic fluid was exudative, consisting of mature-looking B-lymphocytes, which were morphologically and immunophenotypically similar to peripheral blood and bone marrow cells. The patient was treated with chemotherapy and achieved a good response and diminution of ascitic fluid accumulation.

关键词： Ascites Chronic lymphocytic leukemia

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