A two step facile synthesis of new steroidal linear and angular pyranones having anti-mycobacterial activity

作     者：Shams-uz-zaman Tabassum Siddiqui Mohd.Gulfam Alam Najmul Islam 

作者机构：Department of Chemistry(Steroid Lab)Aligarh Muslim University Department of BiochemistryFaculty of medicineJ.N.Medical College 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第2期

页      面：153-157页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：Steroidal linear and angular pyranones Acetyl hydroxy derivative of steroids Pyrrolidine Acetyl chloride Dean Stark separator Anti-mycobacterial activity 

摘      要：Title compounds 2′,2′-dimethylcholesta-2,4-dien[3,2-b]-pyran-4′-one （3）, 2′,2′-dimethyl-3β-substituted cholesta-4,6-dien[7,6- b]-pyran-4′-one （6a,b） and （6c） were prepared by the cyclization of 2-acetylcholesta-2,4-dien-3-ol （2）, 6-acetyl-3β-substituted- cholesta-4,6-dien-7-ol （Sa,b） and （5c） respectively, with pyrrolidine, dry benzene and dry acetone using Dean Stark separator through conventional heating. Furthermore, compounds were also found to be active against Mycobacterium tuberculosis.