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Genomics, Proteomics & Bioinformatics 2012年第1期10卷 44-50页

作者： Dheeraj Ravella Muthukumarasamy Uthaya Kumar durairaj sherlin Mani Shankar Marthandan Kirti Vaishnavi Kanagaraj Sekar Bioinformatics Centre (Centre of Excellence in Structural Biology and Bio-computing) Supercomputer Education and Research Centre Indian Institute of Science Bangalore 560012 India

The function of a protein molecule is greatly influenced by its three-dimensional （3D） structure and therefore structure prediction will help identify its biological function. We have updated Sequence, Motif and Structure （SMS）, the database of structurally rigid peptide fragments, by combining amino acid sequences and the corre- sponding 3D atomic coordinates of non-redundant （25%） and redundant （90%） protein chains available in the Protein Data Bank （PDB）. SMS 2.0 provides information pertaining to the peptide fragments of length 5-14 resi- dues. The entire dataset is divided into three categories, namely, same sequence motifs having similar, intermedi- ate or dissimilar 3D structures. Further, options are provided to facilitate structural superposition using the pro- gram structural alignment of multiple proteins （STAMP） and the popular JAVA plug-in （Jmol） is deployed for visualization. In addition, functionalities are provided to search for the occurrences of the sequence motifs in other structural and sequence databases like PDB, Genome Database （GDB）, Protein Information Resource （PIR） and Swiss-Prot. The updated database along with the search engine is available over the World Wide Web through the following URL http：//***/sms/.

关键词： non-redundant protein chains sequence motifs 3D structure structural superposition

Effect of process parameters on springback behaviour during air bending of electrogalvanised steel sheet

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 183-189页

作者： durairaj VASUDEVAN Rajumani SRINIVASAN Palani PADMANABHAN Department of Mechanical Engineering PSNA College of Engineering and Technology Department of Mechanical Engineering RVS College of Engineering and Technology Bharath Niketan Engineering College

This work aims to study the springback behaviour of electrogalvanised (EG) steel sheets during the air bending *** have been conducted to analyse the influence of various parameters such as coating thickness,orientation of the sheet,punch radius,die radius,die opening,punch velocity,and punch travel on springback *** is established that the springback increases with increasing coating thickness,punch radius,punch travel,die radius,die opening,and punch *** 90° orientation exhibits higher springback than 0° orientation.

关键词： Springback Electrogalvanised (EG) steel Air bending

Functional expression and regulation of eukaryotic cytochrome P450 enzymes in surrogate microbial cell factories

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Engineering Microbiology 2022年第1期2卷 17-34页

作者： Pradeepraj durairaj Shengying Li State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237ShandongChina Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237ShandongChina

Cytochrome P450(CYP)enzymes play crucial roles during the evolution and diversification of ancestral monocel-lular eukaryotes into multicellular eukaryotic organisms due to their essential functionalities including catalysis of housekeeping biochemical reactions,synthesis of diverse metabolites,detoxification of xenobiotics,and con-tribution to environmental *** CYPs with versatile functionalities are undeniably regarded as promising biocatalysts with great potential for biotechnological,pharmaceutical and chemical industry ***,the modes of action and the challenges associated with these membrane-bound proteins have hampered the effective utilization of eukaryotic CYPs in a broader *** review is focused on comprehen-sive and consolidated approaches to address the core challenges in heterologous expression of membrane-bound eukaryotic CYPs in different surrogate microbial cell factories,aiming to provide key insights for better studies and applications of diverse eukaryotic CYPs in the *** also highlight the functional significance of the previously underrated cytochrome P450 reductases(CPRs)and provide a rational justification on the progression of CPR from auxiliary redox partner to function modulator in CYP catalysis.

关键词： Cytochrome P450 enzymes Cytochrome P450 reductase Membrane-bound proteins N-terminal transmembrane domain Heterologous expression Microbial cell factories Redox partners Electron transfer

P systems generating iso-picture languages

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Progress in Natural Science:Materials International 2008年第5期18卷 617-622页

作者： Subbaiah Annadurai Thiyagarajan Kalyani Vincent Rajkumar Dare durairaj Gnanaraj Thomas Department of Mathematics St. Joseph’s College of Engineering Department of Mathematics Madras Christian College Tambaram

P systems generating rectangular arrays and hexagonal arrays have been studied in the literature, bringing together the two areas of theoretical computer science, namely membrane computing and picture languages. Recently, a new class of picture languages called the class of iso-picture languages generating interesting picture languages has been introduced. In this paper, we develop a class of tissue-like P systems with active membranes as a generative device for iso-picture languages.

关键词： P system Iso-picture Languages

Multiferroic Consequence of Porous (BiFeO_3)_x–(BiCrO_3)_(1-x) Composite Thin Films by Novel Sol–Gel Method

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Acta Metallurgica Sinica(English Letters) 2018年第3期31卷 299-307页

作者： William Raja Victor Marikani Arumugam Thiruramanathan Pandirengan Madhavan durairaj Raghavendra Reddy Varimalla Department of Physics Mepco Schlenk Engineering College Department of Chemistry Mepco Schlenk Engineering College UGC-DAE Consortium for Scientific Research University Campus

In this work,we have presented a spin-coating method to produce thin films started with pure BiCrO3（BCO）and ended up with BiFeO3（BFO）by increasing x values in the（BiFeO3）x-（BiCrO3）1-x *** the produced thin films have been crystallized at the annealing temperatures of 400 ℃ for 0.5 *** XRD and EDAX spectrums give insight that the two crystal phases related to BCO and BFO stayed together within the thin film *** analysis showed that the prepared composite had macroporous morphology with interconnected pores and its width（size）decreased with increasing x *** strong correlations are observed among the microstructure,dielectric,ferroelectric,ferromagnetic properties and Fe *** all composites,the composition of 0.75 shows an attractive magnetization,polarization,switching and improved dielectric behaviors at room *** increase in the multiferroic characteristics of 0.75 composition is due to arise of lower leakage current by causing reduction in oxygen vacancy density,and enhancement of super-exchange magnetic interaction between Fe3＋ and Cr3＋ at BFO/BCO interface *** result shows that the thin layer on Pt（111）/Ti/SiO2/Si substrate possesses simultaneously improved ferroelectric and ferromagnetic properties which make an inaccessible potential application for nonvolatile ferroelectric memories.

关键词： Multiferroic Dual-phase composites Spin-coating method NV-Fe-RAM PUND

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Trajectory P system

Progress in Natural Science:Materials International 2008年第5期18卷 611-616页

Membrane computing is a branch of natural computing aiming to abstract computing ideas for the structure and the functioning of living cells as well as from the way the cells are organized in tissues or higher-order structures. Trajectories are used as a tool for modeling language operations and other related objects. A trajectory P system consists of a membrane structure in which the object in each mem- brane is a collection of words and the evolutionary rules are given in terms of trajectories. In this paper, we present some properties of trajectory P systems.

关键词： Membrane computing Shu e trajectories Parallel computation

Identification of miR-802-5p and its involvement in type 2 diabetes mellitus

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World Journal of Diabetes 2020年第12期11卷 567-571页

作者： Kaushik Vishnu Rajkumar Ganesh Lakshmanan durairaj Sekar Department of Anatomy Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical Science(SIMATS)Saveetha UniversityChennai 600077India Dental Research Cell and Biomedical Research Unit(DRC-BRULAC) Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical Science(SIMATS)Saveetha UniversityChennai 600077India

MicroRNAs(miRNA)are recently discovered endogenous,small noncoding RNAs(of 22 nucleotides)that play pivotal roles in gene *** are involved in post-transcriptional control of gene *** are emerging as important regulators of cell proliferation,development,cancer formation,stress responses,cell death and physiological *** evidence has demonstrated the human miRNAs bind to their target mRNA sequences with perfect or near-perfect sequence *** provides a powerful strategy for discovering potential type 2 diabetes mellitus(T2DM)targets and gives the probability to exploit them for diagnostic and therapeutic *** 6%of the world population is affected by T2DM,and it is recognized as a global epidemic by the World Health *** present there is no valid biomarker to control or manage ***,the present study applied a mature sequence of miRNAs from publicly accessible databases to identify the miRNA from T2DM expressed sequence tags,and the results are detailed and discussed below.

关键词： MicroRNAs Type 2 diabetes mellitus miR-802-5p Biomarker Expressed sequence tags Disease

Association of angiotensin converting enzyme gene insertion/deletion polymorphism with essential hypertension in south Indian population

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Genes & Diseases 2016年第2期3卷 159-163页

作者： Ramalingam Krishnan durairaj Sekar Santha karunanithy Sethupathy Subramanium Narayana Medical College and Hospital Nellore605005India Rajamuthaiya Medical College Annamalai UniversityChidhambaram605003India

Genetic,environmental and demographic factors contribute to the development of essential *** polymorphism of Rennin-angiotensin-aldosterone system(RAAS)has been extensively studied to determine the genetic susceptibility to *** insertion/deletion(I/D)angiotensin converting enzyme(ACE)polymorphism has been established as a cardiovascular risk factor in some population,but its association with essential hypertension is *** study sought to determine the association of I/D polymorphism of the ACE gene in south Indian essential hypertensive subjects.A total of 208 clinically diagnosed essential hypertensive patients without any associated diseases and 220 healthy control subjects were included in this *** and allelic frequency of Insertion(I)and Deletion(D)polymorphism at the 287 base pair Alu repeat sequence in the intron 16 of ACE gene were *** distribution of II,ID,DD genotypes of ACE gene was 28.3%,32.6%and 38.9%respectively in essential hypertensive patients and to 53.6%,26.3%and 20%in *** allele frequency for D allele is 0.58 in essential hypertension as compared to 0.34 of control *** genotype and allele frequency of ACE gene polymorphism is significantly differed in patients when compared to *** conclusion,the I/D polymorphism of ACE gene is associated with Indian essential hypertension.

关键词： Angiotensin converting enzyme Essential hypertension Insertion/deletion polymorphism Renin angiotensin aldosterone system Genotypes

Preliminary Investigation of Copper Joints Soldered with Sn58Bi

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Journal of Harbin Institute of Technology(New Series) 2022年第1期29卷 57-63页

作者： Amares Singh Teow Sinn Khai Rajkumar durairaj Amer Ahmed Qassem Saleh Center for Advanced Materials Research and Manufacturing Processes SEGi UniversityPetaling Jaya 47810SelangorMalaysia Lee Kong Chian Faculty of Engineering and Science University Tunku Abdul RahmanKajang 43000SelangorMalaysia

In recent years,intensive studies have been carried out to find an alternative for Tin(Sn)⁃Lead(Pb)solder alloys with increasing demand over lower temperature solder alloys in current electronic packaging *** temperature operational solder alloys seem to produce drawback to other components on the printed circuit board(PCB).Low melting temperature Sn58Bi substrate as a potential replacement was investigated in this paper based on the melting properties,wettability,and shear *** Sn58Bi was soldered at a temperature below 200℃on the Cu substrate,and the shear strength and contact angle were calculated.A peak temperature(melting temperature,T_(M))of 144.83℃was *** lap joint method was performed at a strain rate of 0.1 mm/min and an average shear strength of 23.4 MPa was found from three *** contact angle(wettability)was calculated to study the solder joint behaviour at reflow temperature of 170℃.The contact angle of the Sn58Bi was found to be 32.4°and considered to be desired value since the angle is less than 50°.The low temperature soldering provides a preliminary result to allow further application on the real PCB.

关键词： SnBi solder low temperature shear strength contact angle

Effect of Mo and ZrO_(2)nanoparticles addition on interfacial properties and shear strength of Sn58Bi/Cu solder joint

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2619-2628页

作者： Amares SINGH Hui Leng CHOO Wei Hong TAN Rajkumar durairaj School of Engineering Faculty of Innovation&TechnologyTaylor’s UniversitySubang Jaya47500SelangorMalaysia Faculty of Mechanical Engineering&Technology Universiti Malaysia Perlis(UniMAP)Pauh Putra Campus02600 ArauPerlisMalaysia Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul RahmanJalan Sungai LongBandar Sungai Long43000 KajangSelangorMalaysia

The influence of Mo and ZrO_(2)nanoparticles addition on the interfacial properties and shear strength of Sn58Bi solder joint was *** interfacial microstructures of Sn58Bi/Cu,Sn58Bi+Mo/Cu and Sn58Bi+ZrO_(2)/Cu solder joints were analysed using a scanning electron microscope(SEM)coupled with energy dispersive X-ray(EDX)and the X-ray diffraction(XRD).Intermetallic compounds(IMCs)of MoSn_(2)are detected in the Sn58Bi+Mo/Cu solder joint,while SnZr,Zr_(5)Sn_(3),ZrCu and ZrSn_(2)are detected in Sn58Bi+ZrO_(2)/Cu solder *** layers for both composite solders comprise of Cu_(6)Sn_(5) and Cu_(3)*** SEM images of these layers were used to measure the IMC layer’s *** average IMC layer’s thickness is 1.4431μm for Sn58Bi+Mo/Cu and 0.9112μm for Sn58Bi+ZrO_(2)/Cu solder *** strength of the solder joints was investigated via the single shear lap test *** average maximum load and shear stress of the Sn58Bi+Mo/Cu and Sn58Bi+ZrO_(2)/Cu solder joints are increased by 33%and 69%,respectively,as compared to those of the Sn58Bi/Cu solder *** comparing both composite solder joints,the latter prevails better as adding smaller sized ZrO_(2)nanoparticles improves the interfacial properties granting a stronger solder joint.

关键词： lead-free solder interfacial microstructure IMC layer thickness shear strength dislocation density ZrO_(2)nanoparticles Mo nanoparticles