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Over-starvation aggravates intestinal injury and promotes bacterial and endotoxin translocation under high-altitude hypoxic environment

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World Journal of Gastroenterology 2011年第12期17卷 1584-1593页

作者： Qi-Quan zhou ding-zhou yang Yong-Jun Luo Su-Zhi Li Fu-Yu Liu Guan-Song Wang Department of High Altitude Disease College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine Ministry of EducationThird Military Medical universityChongqing 400038China Research Center of Mountain Sickness General Hospital of Tibetan Military Area CommandLhasa 850007Tibet Autonomous RegionChina Institute of Respiratory Diseases Xinqiao HospitalThird Military Medical UniversityChongqing 400037China

AIM:To study whether over-starvation aggravates intestinal mucosal injury and promotes bacterial and endotoxin translocation in a high-altitude hypoxic ***:Sprague-Dawley rats were exposed to hy-pobaric hypoxia at a simulated altitude of 7000 m for 72 *** nitrate was used as a tracer to detect intestinal *** apoptosis was observed with terminal deoxynucleotidyl transferase dUTP nick end labeling *** levels of diamino oxidase(DAO),malondialdehyde(MDA),glutamine(Gln),superoxide dismutase(SOD) and endotoxin were measured in intestinal *** translocation was detected in blood culture and intestinal *** addition,rats were given Gln intragastrically to observe its protective effect on intestinal ***:Apoptotic epithelial cells,exfoliated villi and inflammatory cells in intestine were increased with edema in the lamina propria accompanying effusion of red blood *** particles were found in the intercellular space and intracellular *** translocation to mesenteric lymph nodes(MLN) and spleen was *** serum endotoxin,DAO and MDA levels were significantly higher while the serum SOD,DAO and Gln levels were lower in intestine(P< 0.05).The bacterial translocation number was lower in the high altitude hypoxic group than in the high altitude starvation group(0.47±0.83 vs 2.38±1.45,P<0.05).The bacterial translocation was found in each organ,especially in MLN and spleen but not in peripheral *** bacterial and endotoxin translocations were both markedly improved in rats after treatment with ***:High-altitude hypoxia and starvation cause severe intestinal mucosal injury and increase bacterial and endotoxin translocation,which can be treated with Gln.

关键词： High altitude Hypoxia Starvation Intestinal mucosal injury Bacterial translocation Endotoxin Glutamine

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Frictional contact analysis of a rigid solid with periodic surface sliding on the thermoelectric material

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 179-196页

作者： Yali ZHANG Yueting zhou Shenghu ding School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Understanding and characterizing rough contact and wavy surfaces are essential for developing effective strategies to mitigate wear,optimize lubrication,and enhance the overall performance and durability of mechanical *** sliding friction contact problem between a thermoelectric(TE)half-plane and a rigid solid with a periodic wavy surface is the focus of this *** simplify the problem,we utilize mixed boundary conditions,leading to a set of singular integral equations(SIEs)with the Hilbert *** analytical solutions for the energy flux and electric current density are obtained by the variable transform method in the context of the electric and temperature *** contact problem for the elastic field is transformed into the second-kind SIE and solved by the Jacobi ***,the smoothness of the wavy contact surface ensures that there are no singularities in the surface contact stress,and ensures that it remains free at the contact *** on the plane strain theory of elasticity,the analysis primarily examines the correlation between the applied load and the effective contact *** distribution of the normal stress on the surface with or without TE loads is discussed in detail for various friction ***,the obtained results indicate that the in-plane stress decreases behind the trailing edge,while it increases ahead of the trailing edge when subjected to TE loads.

关键词： wavy surface periodic contact thermoelectric(TE)material Hilbert integral kernel

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Research on the mechanism of the two-dimensional ultrasonic surface burnishing process to enhance the wear resistance for aluminum alloy

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Friction 2024年第3期12卷 490-509页

作者： Zhen-Yu zhou Qiu-yang ZHENG Yu LI Cong ding Guang-Jian PENG Zhong-Yu PIAO College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

The gradient nanostructure is machined on the aluminum(Al)alloy by the two-dimensional ultrasonic surface burnishing process(2D-USBP).The mechanism of why the gradient nanostructure enhances wear resistance is *** mechanical properties and microstructure characterization for the gradient nanostructure are performed by operating a nanoindenter,transmission electron microscopy(TEM),and electron backscattered diffraction(EBSD).Dry wear tests are performed on the samples before and after machining to evaluate the wear resistance and *** effect of the gradient nanostructure on the wear resistance is explored by developing the crystal plasticity(CP)finite element and molecular dynamics(MD)*** characterization results show that the 2D-USBP sample prepared a gradient structure of~600μm thick on the aluminum surface,increasing the surface hardness from 1.13 to 1.71 GPa and reducing the elastic modulus from 78.84 to 70.14 *** optimization of the surface microstructure and the increase of the mechanical properties effectively enhance the wear resistance of the sample,with 41.20%,39.07%,and 54.58% of the wear scar areas for the 2D-USBP treated samples to the original samples under 5,10,and 15 N loads,*** gradient nanostructure hinders the slip of dislocations inside the sample during the wear process and reduces the size and scope of plastic deformation;meanwhile,the resistance to deformation,adhesion,and crack initiation and propagation of the sample surface is improved,resulting in enhanced wear resistance.

关键词： structural superlubricity lattice registry elastic deformation strained solitons crystal plasticity molecular dynamics simulations

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Design strategies for rechargeable aqueous metal-ion batteries

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Science China Chemistry 2024年第1期67卷 165-190页

作者： yang Li Xin Zhao Yifu Gao Yichen ding Zhichun Si Liubing Dong Dong zhou Feiyu Kang Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China

Rechargeable aqueous metal-ion batteries(AMBs)have attracted extensive scientific and commercial interest due to their potential for cost-effective,highly safe,and scalable stationary energy ***,their limited output voltage,inadequate energy density,and poor reversibility of ambiguous electrode reactions in aqueous electrolytes strongly limit their practical *** review aims to elucidate the challenges of existing AMBs from the material design to whole device *** summarize the emerging electrochemistry,fundamental properties,and key issues in interfacial behaviors of various classes of prevailing AMBs,including aqueous alkali metal-ion batteries and multivalent-ion batteries,and present an appraisal of recent advances for addressing the performance ***,the progress of zinc-ion batteries is highlighted to provide a ubiquitous guideline for their commercialization in the grid-scale energy ***,we figure out the dominating general challenges for achieving high-performance AMBs,laying out a perspective for future breakthroughs.

关键词： aqueous metal-ion batteries aqueous alkali metal-ion batteries zinc-ion batteries interfacial behavior stationary energy storage

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Harnessing bacteria for tumor therapy:Current advances and challenges

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Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： Lina Guo Jinsong ding Wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

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The City of Nanjing

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China City Planning Review 1988年第4期 61-71页

作者： zhou ding yang Rongliang Ye Maozhen

Ⅰ.Natural and Geographicalconditions of Nanjing and Its Re-sourcesThe City of Nanjing is situated in thesouthwest part of Jiangsu Province at the

关键词： The City of Nanjing

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Effective removal of Sb(V)from aqueous solutions by micro-electrolysis with composite scrap iron-manganese as filler

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第6期25卷 516-524页

作者： Shangkun ding Saihua HUANG Yiping ZHANG Yongchao zhou Institute of Municipal Engineering Zhejiang UniversityHangzhou310058China Zhejiang University of Water Resources and Electric Power Hangzhou310018China

Micro-electrolysis(ME)technology is investigated for improving the efficiency of removal of pentavalent antimony(Sb(V))from the *** this study,an ME system composed of scrap iron filings,waste manganese fillings,and activated carbon(Fe-Mn-C ME)was used to efficiently remove Sb(V).The results proved that,compared with conventional iron-carbon micro-electrolysis(Fe-C ME),Fe-Mn-C ME significantly enhances the removal rate of Sb(V)when the hydraulic retention time is 10–24 *** Fe-Mn flocs produced by this system were analyzed using X-ray diffraction(XRD),energy-dispersive X-ray spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS),and Brunauer-Emmett-Teller(BET)surface area analysis,which revealed that the flocs were mostly Mn-substituted FeOOH and had a relatively larger specific surface area,providing better adsorption ***,it was found that the removal rate of Sb(V)decreased as the iron-carbon mass ratio increased,while it first increased and then decreased as the manganese content *** reduction of Fe(III)was accelerated with an increase in the addition of manganese,leading to an increase in the concentration of Fe(II).The electron transfer and the formation of Fe(II)were facilitated by the potential difference between manganese and carbon,as well as by the formation of microcells between iron and manganese,which improved the reduction ability of Sb(V).From our thorough investigation and research,this is the first report that has proposed Fe-Mn-C ME for removing *** provides a novel approach and technological support for removing Sb(V)efficiently.

关键词： Antimony Iron Manganese Micro-electrolysis(ME) Electrochemistry Mechanism

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Crystalline-amorphization-recrystallization structural transition and emergent superconductivity in van der Waals semiconductor SiP under compression

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 115-122页

作者： Chunhua Chen Zhenyu ding Yonghui zhou Yifang Yuan Nixian Qian Jing Wang Shuyang Wang Ying zhou Chao An Min Zhang Xuliang Chen Xiaoping yang Mingliang Tian Zhaorong yang Anhui Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPSChinese Academy of SciencesHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230026China Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityHefei 230601China Institutes of Physical Science and Information Technology Anhui UniversityZhengzhou 450001China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

van der Waals(vdW)semiconductors have gained significant attention due to their unique physical properties and promising applications,which are embedded within distinct crystallographic ***,we report a pressure-induced crystallineamorphization-recrystallization transition under compression in binary vdW semiconductor *** compression to 52 GPa,bulk SiP undergoes a consecutive phase transition from pristine crystalline to amorphous phase,ultimately to recrystallized *** employing synchrotron X-ray diffraction experiments in conjunction with high-pressure crystal structure searching techniques,we reveal that the recrystallized Si P hosts a tetragonal structure(space group I4mm)and further transforms partially into a cubic phase(space group Fm3m).Consistently,electrical transport and alternating-current magnetic susceptibility measurements indicate the presence of three superconducting phases,which are embedded in separate crystallographic symmetries—the amorphous,tetragonal,and cubic ***,a high superconducting transition temperature of 12.3 K is observed in its recovered tetragonal phase during *** findings uncover a novel phase evolution path and elucidate a pressure-engineered structure-property relationship in vdW semiconductor *** results not only offer a new platform to explore the transformation between different structures and functionalities,but also provide new opportunities for the design and exploration of advanced devices based on vdW materials.

关键词： recrystallization transition amorphous

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Bolstering the Mechanical Robustness of Supramolecular Polymer Network by Mechanical Bond

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Chinese Journal of Polymer Science 2024年第10期42卷 1536-1544,I0012页

作者： Yuan-Hao Wang Jing-Xi Deng Jun Zhao Yi ding Li yang Zhao-Ming Zhang Xu-zhou Yan School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai200240China

Supramolecular polymer networks(SPNs)are celebrated for their dynamic nature,yet they often exhibit inadequate mechanical *** far,the quest to bolster the mechanical resilience of SPNs while preserving their dynamic character presents a formidable ***,we introduce[2]rotaxane into SPN to serve as another cross-link,which could effectively enhance the mechanical robustness of the polymer network without losing the dynamic *** with SPN,the dually cross-linked network(DPN)demonstrates superior breaking strength,Young’s modulus,puncture force and toughness,underscoring its superior ***,the cyclic tensile tests reveal that the energy dissipation capacity of DPN rivals,and in some cases surpasses,that of SPN,owing to the efficient energy dissipation pathway facilitated by[2]*** addition,benefiting from stable topological structure of[2]rotaxane,DPN exhibits accelerated recovery from deformation,indicating superior elasticity compared to *** strategy elevates the performance of SPNs across multiple metrics,presenting a promising avenue for the development of high-performance dynamic materials.

关键词： Rotaxane cross-links Dually cross-linked network Supramolecular polymer network Host-guest recognition Dynamic materials

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Trade-offs between chemical resistance to herbivory and responses to abiotic stresses in invasive plants

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Journal of Plant Ecology 2024年第2期17卷 18-23页

作者： Lifeng zhou Wandong Yin Jianqing ding State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China

INTRODUCTION Plants change their traits to respond to shifting environments,enabling them to defend against biotic stresses such as herbivorous insects,and/or tolerate abiotic stresses,such as extreme climate(Callaway et al.2022;Zhang et al.2018,2022).There are often costs when plants produce secondary chemicals to adapt to varying biotic or abiotic environments(Abdala-Roberts et al.2016).

关键词： traits ). environments

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