Over-starvation aggravates intestinal injury and promotes bacterial and endotoxin translocation under high-altitude hypoxic environment

作     者：Qi-Quan Zhou Ding-Zhou Yang Yong-Jun Luo Su-Zhi Li Fu-Yu Liu Guan-Song Wang 

作者机构：Department of High Altitude DiseaseCollege of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude MedicineMinistry of EducationThird Military Medical universityChongqing 400038China Research Center of Mountain SicknessGeneral Hospital of Tibetan Military Area CommandLhasa 850007Tibet Autonomous RegionChina Institute of Respiratory DiseasesXinqiao HospitalThird Military Medical UniversityChongqing 400037China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第12期

页      面：1584-1593页

核心收录：

学科分类：10[医学] 

基　　金：Supported by Scientific and Technical Research Funds from Chinese PLA during the Eleventh Five-Year Plan Period,No. 2008G093 National Natural Science Foundation of China,No. 30900715 National Science and Technology Ministry,No. 2009BAI85B03 

主　　题：High altitude Hypoxia Starvation Intestinal mucosal injury Bacterial translocation Endotoxin Glutamine 

摘      要：AIM:To study whether over-starvation aggravates intestinal mucosal injury and promotes bacterial and endotoxin translocation in a high-altitude hypoxic ***:Sprague-Dawley rats were exposed to hy-pobaric hypoxia at a simulated altitude of 7000 m for 72 *** nitrate was used as a tracer to detect intestinal *** apoptosis was observed with terminal deoxynucleotidyl transferase dUTP nick end labeling *** levels of diamino oxidase(DAO),malondialdehyde(MDA),glutamine(Gln),superoxide dismutase(SOD) and endotoxin were measured in intestinal *** translocation was detected in blood culture and intestinal *** addition,rats were given Gln intragastrically to observe its protective effect on intestinal ***:Apoptotic epithelial cells,exfoliated villi and inflammatory cells in intestine were increased with edema in the lamina propria accompanying effusion of red blood *** particles were found in the intercellular space and intracellular *** translocation to mesenteric lymph nodes(MLN) and spleen was *** serum endotoxin,DAO and MDA levels were significantly higher while the serum SOD,DAO and Gln levels were lower in intestine(P 0.05).The bacterial translocation number was lower in the high altitude hypoxic group than in the high altitude starvation group(0.47±0.83 vs 2.38±1.45,P0.05).The bacterial translocation was found in each organ,especially in MLN and spleen but not in peripheral *** bacterial and endotoxin translocations were both markedly improved in rats after treatment with ***:High-altitude hypoxia and starvation cause severe intestinal mucosal injury and increase bacterial and endotoxin translocation,which can be treated with Gln.