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Detecting and Adjusting Temporal Inhomogeneity in chinese Mean Surface Air Temperature Data

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Advances in Atmospheric Sciences 2004年第2期21卷 260-268页

作者：李庆祥刘小宁张洪政 Thomas c.PETERSON david R.EASTERLING National Meteorological center China Meteorological Administration Beijing 100081 National climatic Data center National Oceanic and Atmospheric Administration Asheville NC28801 USA

Adopting the Easterling-Peterson (EP) techniques and considering the reality of chinese meteorological observations, this paper designed several tests and tested for inhomogeneities in all chinese historical surface air temperature series from 1951 to 2001. The result shows that the time series have been widely impacted by inhomogeneities resulting from the relocation of stations and changes in local environment such as urbanization or some other factors. Among these factors, station relocations caused the largest magnitude of abrupt changes in the time series, and other factors also resulted in inhomogeneities to some extent. According to the amplitude of change of the difference series and the monthly distribution features of surface air temperatures, discontinuities identified by applying both the E-P technique and supported by china's station history records, or by comparison with other approaches, have been adjusted. Based on the above processing, the most significant temporal inhomogeneities were eliminated, and china's most homogeneous surface air temperature series has thus been created. Results show that the inhomogeneity testing captured well the most important change of the stations, and the adjusted dataset is more reliable than ever. This suggests that the adjusted temperature dataset has great value of decreasing the uncertaities in the study of observed climate change in china.

关键词： china surface air temperature homogeneity testing and adjusting

A new software for automated counting of glistenings in intraocular lenses in vivo

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1237-1242页

作者： Nick Stanojcic christopher c.Hull Eduardo Mangieri Nathan Little david O’Brart Department of Ophthalmology Guy’s and St Thomas’NHS Foundation TrustLondon SE17EHUK centre for Applied Vision Research School of Health SciencesUniversity of LondonLondon EC1V 0HBUK Sparca Ltd CroydonSurrey CR01QQUK King’s college London WC2R 2LSUK

AIM:To assess the performance of a bespoke software for automated counting of intraocular lens(IOL)glistenings in slit-lamp ***:IOL glistenings from slit-lamp-derived digital images were counted manually and automatically by the bespoke *** images of one randomly selected eye from each of 34 participants were used as a training set to determine the threshold setting that gave the best agreement between manual and automatic grading.A second set of 63 images,selected using randomised stratified sampling from 290 images,were used for software *** images were obtained using a previously described ***-derived automated glistenings counts were compared to manual counts produced by three ***:A threshold value of 140 was determined that minimised the total deviation in the number of glistenings for the 34 images in the training *** this threshold value,only slight agreement was found between automated software counts and manual expert counts for the validating set of 63 images(κ=0.104,95%cI,0.040-0.168).Ten images(15.9%)had glistenings counts that agreed between the software and manual *** were 49 images(77.8%)where the software overestimated the number of ***:The low levels of agreement show between an initial release of software used to automatically count glistenings in in vivo slit-lamp images and manual counting indicates that this is a non-trivial *** improvement involving a dialogue between software developers and experienced ophthalmologists is required to optimise *** results suggest that validation of software is necessary for studies involving semi-automatic evaluation of glistenings.

关键词： new software automated counting glistenings intraocular lenses slit-lamp images

Hepatic lipogranulomas in patients with chronic liver disease: Association with hepatitis c and fatty liver disease

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World Journal of Gastroenterology 2010年第40期16卷 5065-5069页

作者： Hongfa Zhu Henry c Bodenheimer david J clain Albert D Min Neil D Theise Department of Pathology Mount Sinai School of MedicineNewYorkNY10029United States Department of Medicine (Divisions of Digestive Diseases)Beth Israel Medical center Albert Einstein college of Medicine Department of Pathology Beth Israel Medical CenterAlbert Einste in College of MedicineNew YorkNY 10003United States

AIM: To study the significance and clinical implication of hepatic lipogranuloma in chronic liver diseases, including fatty liver disease and hepatitis c. METHODS: A total of 376 sequential, archival liver biopsy specimens were reviewed. Lipogranuloma, steatosis and steato-fibrosis were evaluated with combined hematoxylin and eosin and Masson’s trichrome staining. RESULTS: Fifty-eight (15.4%) patients had lipogranuloma, including 46 patients with hepatitis c, 14 patients with fatty liver disease, and 5 patients with other diseases. Hepatic lipogranuloma was more frequently seen in patients with hepatitis c (21%) and fatty liver disease (18%), and its incidence was significantly higher than that in control group (P ctively). In addition, 39 out of the 58 patients with lipogranuloma were associated with steatosis and/or steato-fibrosis. Of the 18 lipogranuloma patients with clinical information available for review, 15 (83%) had risk factors associated with fatty liver disease, such as alcohol use, obesity, hyperlipidemia, and diabetes mellitus. Although the incidence of these risk factors was greater in patients with lipogranuloma than in control group (60%), it did not reach statistical significance. cONcLUSION: Hepatic lipogranuloma is not limited to mineral oil use and commonly associated with hepatic steatosis, hepatitis c and fatty liver disease. With additional histological features of steato-fibrosis, lipogranuloma can also be used as a marker of prior hepatic steatosis.

关键词： Lipogranuloma Hepatitis c Fatty liver disease Steatosis Steato-fibrosis

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基于遗传算法和内点法的无功优化混合策略

中国电机工程学报 2005年第15期25卷 67-72页

作者：刘方颜伟 david c.Yu 重庆大学高电压与电工新技术教育部重点实验室重庆市沙坪坝区400044 美国威斯康星-密尔沃基大学美国威斯康星wi53211

基于遗传算法与内点法,文中提出了一种新颖的混合策略来求解无功优化问题:不考虑无功优化中的离散约束,采用内点法求解得到初始解;根据优化变量的不同性质,将原无功优化问题分解为离散优化和连续优化2个子问题,并采用遗传算法和内点法... 详细信息

基于遗传算法与内点法,文中提出了一种新颖的混合策略来求解无功优化问题:不考虑无功优化中的离散约束,采用内点法求解得到初始解;根据优化变量的不同性质,将原无功优化问题分解为离散优化和连续优化2个子问题,并采用遗传算法和内点法交替求解。在遗传迭代的不同阶段,针对种群个体的不同特点,分别对遗传算法和内点法的具体实施方案进行了动态调整,使两者的优化结果互为基础、相互利用,保证了混合策略的整体寻优效率。IEEE30和IEEE118节点系统的仿真计算结果表明:与其他混合算法相比,该混合策略在计算速度和优化效果方面都具有明显的优势。

关键词：电力系统无功优化内点法遗传算法

Hepatitis B virus genotypes in precision medicine of hepatitis Brelated hepatocellular carcinoma:Where we are now

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1097-1103页

作者： caecilia H c Sukowati Sri Jayanti Turyadi Turyadi david H Muljono claudio Tiribelli Eijkman Research center for Molecular Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver cancer Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and Health University of SydneySydney 2050Australia

Hepatitis B virus(HBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(Hcc).HBV genetics are diverse where it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geographical distribution and possible different clinical outcomes in the *** diversity may be associated with the precision medicine for HBV-related Hcc and the success of therapeutical approaches against Hcc,related to different pathogenicity of the virus and host *** Editorial discusses recent updates on whether the classification of HBV genetic diversity is still valid in terms of viral oncogenicity to the Hcc and its precision medicine,in addition to the recent advances in cellular and molecular biology technologies.

关键词： Hepatitis B virus Hepatocellular carcinoma Genotypes Pathogenesis Precision medicine

Through-Foliage Tracking with Airborne Optical Sectioning

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Journal of Remote Sensing 2022年第1期2022卷 234-243页

作者： Rakesh John Amala Arokia Nathan Indrajit Kurmi david c.Schedl Oliver Bimber Institute of computer Graphics Johannes Kepler University LinzLinzAustria University of Applied Sciences Upper Austria HagenbergAustria

Detecting and tracking moving targets through foliage is difficult,and for many cases even impossible in regular aerial images and *** present an initial light-weight and drone-operated 1D camera array that supports parallel synthetic aperture aerial *** main finding is that color anomaly detection benefits significantly from image integration when compared to conventional raw images or video frames(on average 97%vs.42%in precision in our field experiments).We demonstrate that these two contributions can lead to the detection and tracking of moving people through densely occluding forest.

关键词： frames moving image

The importance of public engagement in clinical xenotransplantation

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Health Care Science

Health care Science 2024年第2期3卷 124-130页

作者： Daniel J.Hurst david K.c.cooper Department of Family Medicine Rowan-Virtua School of Osteopathic MedicineStratfordNew JerseyUSA center for Transplantation Sciences Massachusetts General Hospital/Harvard Medical SchoolBostonMassachusettsUSA

Over the past several decades,significant scientific progress in xenotransplantation has brought the field to the threshold of clinical *** the past 3 years in the United States,experimental pig kidney and heart xenotransplantation have been performed on human subjects recently declared dead by neurological criteria(decedents).In addition,two pig heart transplants have been carried out in living patients under the United States Food and Drug Administration's expanded access ***,though there has been a flurry of activity there remain unanswered questions regarding how the public views xenotransplantation,what concerns may exist,and how to address these concerns in a meaningful *** paper aims to underscore the importance of public engagement in xenotransplantation,emphasizing the ongoing need for studies to assess public *** current evidence on public engagement studies is reviewed and gaps in our understanding are *** propose practical steps to advance this *** studies to determine the extent of racial/ethnic differences in attitudes to xenotransplantation should be *** and descriptive analysis of certain religious viewpoints—especially minority faiths—would be *** public engagement is an important aspect of public acceptance of novel research that is accompanied by risk,we suggest that xenotransplantation biotechnology companies might consider leading the way in funding this research.

关键词： clinical trials ethics public engagement viewpoints xenotransplantation

comparison of four scanning mobility particle sizers at the Fresno Supersite

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Particuology 2011年第3期9卷 204-209页

作者： John G. Watson Judith c. chow david A. Sodeman Douglas H. Lowenthal M.-c. Oliver chang Kihong Park Xiaoliang Wang Desert Research Institute 2215 Raggio Parkway Reno NV 89512 USA Institute of Earth Environment Chinese Academy of Sciences 10 Fenghui South Road Xi'an High Tech Zone Xi'an 710075 China San Diego Air Pollution control District San Diego CA USA. california Air Resources Board El Monte CA USA. Gwangju Institute of Science and Technology Gwangju Korea.

Size distributions of ambient aerosols at the Fresno Supersite were measured with four commercially available scanning mobility particle sizers （SMPS）. TSI nano, TSI standard, Grimm, and MSP instruments were collocated at the Fresno Supersite and particle size distributions were measured continuously from August 18 through September 18, 2005. For particles with diameters between 10 and 200 nm, differences among hourly-average ambient particle concentrations ranged from 0% between the TSI nano and Grimm in the 30-50 nm size range to 39% between the Grimm and MSP in the 10-30 nm size range. MSP concentrations were 10-33% lower than those measured with the TSI standard for particles smaller than 200 nm. The TSI nano and TSI standard agreed to within 5% in their overlapping size range （10-84 nm）. The TSI nano and Grimm agreed to within 40% for 5-10 nm particles.

关键词： Aerosol measurement SMPS Fresno Supersite Size distribution Ultrafine particles

Statin-induced Liver Injury Patterns: A clinical Review

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Journal of clinical and Translational Hepatology 2022年第3期10卷 543-552页

作者： Leon D.Averbukh Alla Turshudzhyan david c.Wu George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-coA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.

关键词： Drug-induced liver injury Statin cholestatic liver injury Hepatocellular liver injury cholestasis Autoimmune hepatitis