Statin-induced Liver Injury Patterns: A Clinical Review
作者机构：Department of MedicineDivision of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA Department of MedicineDivision of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2022年第10卷第3期
页 面：543-552页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Drug-induced liver injury Statin Cholestatic liver injury Hepatocellular liver injury Cholestasis Autoimmune hepatitis
摘 要：Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-CoA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf Causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.
维普期刊数据库