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Evaluation of therapeutic effectiveness of 131I-antiEGFR-BSA-PCL in a mouse model of colorectal cancer

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World Journal of Gastroenterology 2016年第14期22卷 3758-3768页

作者： Wei Li Yan-hui Ji Cheng-xia Li Zhong-Yun Liu ning Li Lei fang Jin Chang jian Tan Department of Nuclear Medicine Tianjin Medical University General Hospital Tianjin 300052 China Yantai Institute of Coastal Zone Research Chinese Academy of Sciences Yantai 264003 Shandong Province China Institute of Nanobiotechnology School of Materials Science and Engineering Tianjin Key Laboratory of Composites and Functional Materials Tianjin University Tianjin 300072 China

AIM: To investigate the biological effects of internal irradiation, and the therapeutic effectiveness was assessed of ^(131)I-labeled anti-epidermal growth factor receptor(EGFR) liposomes, derived from cetuximab, when used as a tumor-targeting carrier in a colorectal cancer mouse ***: We described the liposomes and characterized their EGFR-targeted binding and cellular uptake in EGFR-overexpressing LS180 colorectal cancer cells. After intra-tumor injections of 74 MBq(740 MBq/m L) ^(131)I-anti EGFR-BSA-PCL, we investigated the biological effects of internal irradiation and the therapeutic efficacy of ^(131)I-anti EGFR-BSA-PCL on colorectal cancer in a male BALB/c mouse model. Tumor size, body weight, histopathology, and SPECT imaging were monitored for 33 d ***: The rapid radioiodine uptake of ^(131)I-antiEGFR-BSA-PCL and ^(131)I-BSA-PCL reached maximum levels at 4 h after incubation, and the ^(131)I uptake of ^(131)I-anti EGFR-BSA-PCL was higher than that of ^(131)I-BSAPCL in vitro. The ^(131)I tissue distribution assay revealed that ^(131)I-anti EGFR-BSA-PCL was markedly taken up by the tumor. Furthermore, a tissue distribution assay revealed that ^(131)I-anti EGFR-BSA-PCL was markedly taken up by the tumor and reached its maximal uptake value of 21.0 ± 1.01 %ID/g(%ID/g is the percentage injected dose per gram of tissue) at 72 h following therapy; the drug concentration in the tumor was higher than that in the liver, heart, colon, or spleen. Tumor size measurements showed that tumor development was significantly inhibited by treatments with ^(131)I-anti EGFR-BSA-PCL and ^(131)I-BSA-PCL. The volume of tumor increased, and treatment rate with ^(131)I-anti EGFR-BSA-PCL was 124% ± 7%, lower than that with ^(131)I-BSA-PCL(127% ± 9%), ^(131)I(143% ± 7%), and normal saline(146% ± 10%). The percentage losses in original body weights were 39% ± 3%, 41% ± 4%, 49% ± 5%, and 55% ± 13%, respectively. The best survival and cure rates were obtained in t

关键词： Radioiodine therapy Colorectal cancer Liposome Epidermal growth factor receptor mouse

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相空间中力学系统的Lie-Mei对称性

物理学报 2006年第8期55卷 3821-3824页

作者：方建会王鹏丁宁中国石油大学(华东)物理科学与技术学院东营257061

研究了相空间中力学系统的一种新对称性———Lie_Mei对称性及其守恒量.提出这种新对称性的定义,给出了系统Lie_Mei对称性的判据,得到了系统Lie_Mei对称性导致的广义Hojman守恒量和Mei守恒量.举例说明了结果的应用.

关键词：相空间力学系统 Lie-Mei对称性守恒量

Hamilton系统Mei对称性的一种新守恒量

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物理学报 2007年第6期56卷 3039-3042页

作者：方建会丁宁王鹏中国石油大学(华东)物理科学与技术学院东营257061

研究Hamilton系统的Mei对称性直接导致的一种新守恒量.给出Hamilton系统的Mei对称性的定义和判据方程,引入谐调函数,得到系统Mei对称性直接导致新守恒量的条件和形式,并给出应用算例.结果表明,谐调函数可根据寻找规范函数的需要适当选取... 详细信息

研究Hamilton系统的Mei对称性直接导致的一种新守恒量.给出Hamilton系统的Mei对称性的定义和判据方程,引入谐调函数,得到系统Mei对称性直接导致新守恒量的条件和形式,并给出应用算例.结果表明,谐调函数可根据寻找规范函数的需要适当选取,从而使规范函数的寻求变得比较容易,而且由于谐调函数的选取具有多样性,因此能够找到系统Mei对称性的更多的守恒量.

关键词： Hamilton系统 Mei对称性新守恒量

非完整力学系统的Noether-Lie对称性

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物理学报 2006年第8期55卷 3817-3820页

作者：方建会丁宁王鹏中国石油大学(华东)物理科学与技术学院东营257061

研究了非完整力学系统的一种新对称性———Noether_Lie对称性及其守恒量.给出了非完整力学系统Noether_Lie对称性的定义和判据,提出系统的Noether_Lie对称性导致Noether守恒量和广义Hojman守恒量的定理.举例说明了结果的应用.Hojman守... 详细信息

研究了非完整力学系统的一种新对称性———Noether_Lie对称性及其守恒量.给出了非完整力学系统Noether_Lie对称性的定义和判据,提出系统的Noether_Lie对称性导致Noether守恒量和广义Hojman守恒量的定理.举例说明了结果的应用.Hojman守恒量是所给出的广义Hojman守恒量的特例.

关键词：非完整力学系统 Noether-Lie对称性 Noether守恒量广义Hojman守恒量

Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population

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Asian Journal of Andrology 2019年第6期21卷 592-597页

作者： Yi-Shuo Wu Xiao-jian Fu Rong Na ding-Wei Ye Jun Qi Xiao-Ling Lin fang Liu jian Gong ning Zhang Guang-Liang jiang Hao-Wen jiang Qiang ding jianfeng Xu Ying-Hao Sun Department of Urology Huashan HospitalFudan UniversityShanghai 200040China Urology Research Center Fudan UniversityShanghai 200040China Program for Personalized Cancer Care NorthShore University HealthSystemEvanstonIL 60201USA Department of Surgery Huashan HospitalFudan UniversityShanghai 200040China Department of Urology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Urology Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Urology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China Department of Urology Changhai HospitalThe Second Military Medical UniversityShanghai 200433China

Risk prediction models including the Prostate Health Index(phi)for prostate cancer have been well established and evaluated in the Western *** aim of this study is to build phi-based risk calculators in a prostate biopsy population and evaluate their performanee in predicting prostate cancer(PCa)and high-grade PCa(Gleason score 27)in the Chinese *** developed risk calculators based on 635 men who underwent initial prostate ***,we validated the performance of prostate-specific antigen(PSA),phi,and the risk calculators in an additional observational cohort of 1045 *** observed that the phi-based risk calculators(risk calculators 2 and 4)outperformed the PSA-based risk calculator for predicting PCa and high-grade PCa in the training *** the validation study,the area under the receiver operating characteristic curve(AUC)for risk calculators 2 and 4 reached 0.91 and 0.92,respectively,for predicting PCa and high-grade PCa,respectively;the AUC values were better than those for risk calculator 1(PSA-based model with an AUC of 0.81 and 0.82,respectively)(all P<0.001).Such superiority was also observed in the stratified population with PSA ranging from 2.0 ng ml^-1 to 10.0 ng ml^-*** curves confirmed that a considerable proportion of unnecessary biopsies could be avoided while applying phi-based risk *** this study,we showed that,compared to risk calculators without phi,phi-based risk calculators exhibited superior discrimination and calibration for PCa in the Chinese biopsy *** these risk calculators also considerably reduced the number of unnecessary biopsies for PCa.

关键词： Chinese p2PSA prostate biopsy Prostate Health Index risk calculator

Identification of a novel p.R1443W mutation in RP1 gene associated with retinitis pigmentosa sine pigmento

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 430-435页

作者： Li Ma Xun-Lun Sheng hui-Ping Li fang-Xia Zhang Ya-Ni Liu Wei-ning Rong jian-Ling Zhang ningxia Eye Hospital People's Hospital of ningxia hui Autonomous Region

AIM:To screen mutations in the retinitis pigmentosa 1(RP1) gene and the rhodopsin(RHO) gene in Chinese patients with retinitis pigmentosa sine pigmento(RPSP)and describe the genotype-phenotype relationship of the mutations.·METHODS:Twenty affected,unrelated Chinese individuals with RPSP(4 autosomal dominant RPSP,12autosomal recessive RPSP and 4 unknown inheritance pattern) were recruited between 2009 and *** clinical features were determined by complete ophthalmologic *** chain reaction(PCR) and direct DNA sequencing were used to screen the entire coding region and splice junctions of the RP1gene and the RHO *** cosegregation analysis and population frequency studies were performed for patients with identified mutations.·RESULTS:Five variants in the RP1 gene and one in the RHO gene were detected in 20 *** missense changes(rs444772,rs446227,rs414352,rs441800) and one non-coding variant(rs56340615) were common SNPs and none of them showed a significant relationship with RPSP.A missense mutation p.R1443W was identified in the RP1 gene in three affected individuals from a family with autosomal dominant RPSP and was found to cosegregate with the phenotype in this family,suggestive of *** addition,population frequency analysis showed the p.R1443W mutation was absent in 300 healthy controls.·CONCLUSION:The identification of p.R1443W mutationcosegregating in a family with autosomal dominant RPSP highlights an atypical phenotype of the RP1 gene mutation,while RHO gene is not associated with the pathogenesis of RPSP in this *** our knowledge,this is the fist mutation identified to associate with RPSP.

关键词： retinitis pigmentosa sine pigmento RP1 and RHO gene gene mutation

Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction

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Translational Neurodegeneration 2012年第1期1卷 123-131页

作者： Jing Pan hui Li jian-fang Ma Yu-Yan Tan Qin Xiao jian-Qing ding Sheng-Di Chen Department of Neurology and Neuroscience Institute Ruijin HospitalShanghai Jiao-Tong University School of MedicineShanghai 200025P.R.China Institute of Health Science Shanghai Institutes for Biological Sciences(SIBS)Chinese Academy of Sciences(CAS)&Shanghai Jiao-Tong University School of MedicineShanghai 200025P.R.China

Curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly *** results of our recent experiments indicated that curcumin could protect dopaminergic neurons from apoptosis in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)mouse model of Parkinson’s disease(PD).The death of dopaminergic neurons and the loss of dopaminergic axon in the striatum were significantly suppressed by curcumin in MPTP mouse *** studies showed that curcumin inhibited JNKs hyperphosphorylation induced by MPTP *** phosphorylation can cause translocation of Bax to mitochondria and the release of cytochrome c which both ultimately contribute to mitochondria-mediated *** pro-apoptosis effect can be diminished by *** experiments demonstrated that curcumin can prevent nigrostriatal degeneration by inhibiting the dysfunction of mitochondrial through suppressing hyperphosphorylation of JNKs induced by *** results suggested that JNKs/mitochondria pathway may be a novel target in the treatment of PD patients.

关键词： JNKs protective inhibited

Identification and characterization of cell cultures with various embryogenic/regenerative potential in cotton based on morphological,cytochemical,and cytogenetical assessment

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Journal of Integrative Agriculture 2019年第1期18卷 1-8页

作者： GUO hui-hui WU jian-fei CHEN Cui-xia WANG Hong-mei ZHAO Yun-lei ZHANG Chao-jun JIA Yin-hua LIU fang ning Tang-yuan CHU Zhao-hui ZENG Fan-chang State Key Laboratory of Crop Biology Ministry of Science and Technology/College of AgronomyShandong Agricultural University State Key Laboratory of Cotton Biology Ministry of Science and Technology/Cotton Research InstituteChinese Academy of Agricultural Sciences Key Laboratory of Water Resources and Drought Resistant Germplasm Improvement Ministry of Agriculture

Somatic embryogenesis(SE) plays a vital role in genetic transformation and massive propagation of important agronomical and economical ***,we conducted a systematic assessment of the morphological,cytochemical,and cytogenetical characteristics of six culture strains with various embryogenic/regenerative potential during SE process in *** indicated that the six cell culture strains had stable ploidy levels,and did not reveal any relationship between the cytogenetic state and their morphogenetic ***,the six culture strains were compared via double staining with Evans blue and Acetocarmine to efficiently distinguish embryogenic and non-embryogenic cells and determine the embryogenic nature of the *** addition,the kind of auxins added in medium affected not only growth property,color,size of cell clumps but also ploidy level and regeneration *** combining analysis of morphological,cytochemical,and cytogenetical characteristics of the cell cultures,we are able to obtain and maintain homogeneous cell population with high morphogenic and regeneration ability and establish efficient somatic embryogenesis and regeneration system from short-term cell cultures in upland cotton,which highlight the application of biotechnological approaches in crop breeding,and above all,to better understand totipotency of cells in higher plants.

关键词： cotton somatic embryogenesis cotton cell culture strains cytochemical EB-AC double staining cytogenetical ploidy stability embryogenic/regenerative potential, morphology

Hydrothermal Synthesis and Characterization of a Novel Supramolecular Network Compound [Co(IN)_2(H_2O)_4](IN=Isonicotinate)

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Chemical Research in Chinese Universities 2002年第4期18卷 385-388页

作者： JIA Hong-bin YU Jie-hui ding Hong XU Ji-qing YE Ling JING Wei-jieWANG Tie-gang XU Jia-ning QU Xue-jian LI Zeng-chun College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130023P.R.China Key Laboratory of Supramolecular Structure and Materials of Ministry of Education Jilin UniversityChangchun 130023P.R.China Department of Chemistry Inner Mongolia University for NationalitiesTongliao 028000P.R.China

A novel supramolecular compound, [Co(IN)_2(H_2O)_4](1), was synthesized by means of the hydrothermal method and its structure was characterized with elemental analysis, FT-IR spectrum, TGA and X-ray diffraction. Though the unit cell structure of the title compound is only monomeric, all these units as building blocks are assembled into a novel three-dimensional supramolecular network via the widely hydrogen-bonding and π-π stacking interactions.

关键词： Hydrothermal synthesis Cobalt(Ⅱ) complex X-Ray diffraction Isonicotinate Supramolecule