Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population

作     者：Yi-Shuo Wu Xiao-Jian Fu Rong Na Ding-Wei Ye Jun Qi Xiao-Ling Lin Fang Liu Jian Gong Ning Zhang Guang-Liang Jiang Hao-Wen Jiang Qiang Ding Jianfeng Xu Ying-Hao Sun 

作者机构：Department of UrologyHuashan HospitalFudan UniversityShanghai 200040China Urology Research CenterFudan UniversityShanghai 200040China Program for Personalized Cancer CareNorthShore University HealthSystemEvanstonIL 60201USA Department of SurgeryHuashan HospitalFudan UniversityShanghai 200040China Department of UrologyRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of UrologyShanghai Cancer CenterFudan UniversityShanghai 200032China Department of UrologyXinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China Department of UrologyChanghai HospitalThe Second Military Medical UniversityShanghai 200433China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2019年第21卷第6期

页      面：592-597页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Clinical Science and Technology Innovation Project of Shanghai Shen Kang Hospital Development Center to QD the National Key Research and Development Plan of China, Precision Medicine Project the Scientific Research Project of Huashan Hospital, Fudan University to YSW 

主　　题：Chinese p2PSA prostate biopsy Prostate Health Index risk calculator 

摘      要：Risk prediction models including the Prostate Health Index(phi)for prostate cancer have been well established and evaluated in the Western *** aim of this study is to build phi-based risk calculators in a prostate biopsy population and evaluate their performanee in predicting prostate cancer(PCa)and high-grade PCa(Gleason score 27)in the Chinese *** developed risk calculators based on 635 men who underwent initial prostate ***,we validated the performance of prostate-specific antigen(PSA),phi,and the risk calculators in an additional observational cohort of 1045 *** observed that the phi-based risk calculators(risk calculators 2 and 4)outperformed the PSA-based risk calculator for predicting PCa and high-grade PCa in the training *** the validation study,the area under the receiver operating characteristic curve(AUC)for risk calculators 2 and 4 reached 0.91 and 0.92,respectively,for predicting PCa and high-grade PCa,respectively;the AUC values were better than those for risk calculator 1(PSA-based model with an AUC of 0.81 and 0.82,respectively)(all P0.001).Such superiority was also observed in the stratified population with PSA ranging from 2.0 ng ml^-1 to 10.0 ng ml^-*** curves confirmed that a considerable proportion of unnecessary biopsies could be avoided while applying phi-based risk *** this study,we showed that,compared to risk calculators without phi,phi-based risk calculators exhibited superior discrimination and calibration for PCa in the Chinese biopsy *** these risk calculators also considerably reduced the number of unnecessary biopsies for PCa.