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中国香港双语儿童初步阅读能力与语音、文字加工关系的研究

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心理学 2002年第7期 173-176页

作者：钟毅平 Catherine McBride-Chang connie Suk-Han ho

采用音节检测、短时言语记忆、快速命名等语音加工任务和汉字、字母、数字等方向加工任务，探讨语音和文字加工在儿童初步阅读中的作用，116名6岁左右的香港双语儿童参加了测试。结果表明：语音加工能力是跨语言的比较稳定的因素，是预... 详细信息

采用音节检测、短时言语记忆、快速命名等语音加工任务和汉字、字母、数字等方向加工任务，探讨语音和文字加工在儿童初步阅读中的作用，116名6岁左右的香港双语儿童参加了测试。结果表明：语音加工能力是跨语言的比较稳定的因素，是预测汉语和英语阅读的较好指标；文字加工具有特异性，即汉字方向加工只能预测汉语阅读，字母方向加工则预测英语阅读。

关键词：语音加工文字加工阅读双语儿童

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北京侨福芳草地

城市环境设计 2013年第8期 232-237页

作者：徐腾 Ulrich Blum Nicole Ip Alicia Tan Pusey Chan Stephane Lacroix Moses Tan Kin Choy Christa Lange Jochen Tombers howard Chung Peter Liu Louisa Williams Colin Foster Rosita Nicknafs Patrick Yue Simon Griffiths Ed Peter connie ho William Tam IDA建筑设计事务所

2000年岁末,北京市中心,来自香港的侨福集团为一座地标性建筑提出了一项挑战性的策划,旨在改变大型综合商业开发项目的成规。它所引得的回应,也是一项时尚、节能且环保的设计,由徐腾(Winston Shu)领衔的香港建筑事务所IDA一手命制。整... 详细信息

2000年岁末,北京市中心,来自香港的侨福集团为一座地标性建筑提出了一项挑战性的策划,旨在改变大型综合商业开发项目的成规。它所引得的回应,也是一项时尚、节能且环保的设计,由徐腾(Winston Shu)领衔的香港建筑事务所IDA一手命制。整个开发项目有微气候调节,运用与北京季候变化相一致的可持续自然手段,实现了水准空前的热舒适度与灵活的使用空间。项目由四座建筑组成,位于一座下沉庭园之中,低于毗邻街道地平面9m。所有的建筑彼此独立,中间是一个L形的满光中庭,宽达24m;其中有空中花园、露台、廊桥彼此穿插错落,均在一道

关键词：精品酒店廊桥商业微气候微小气候办公楼零售商场绿色建筑绿地集团 LEED 北京庭园园林中庭空中花园露台园林建筑设计团队

The Impact of COVID-19 on the Mental-Emotional Wellbeing of Primary Healthcare Professionals: A Descriptive Correlational Study

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International Journal of Mental Health Promotion 2023年第3期25卷 327-342页

作者： Regina Lai-Tong Lee Anson Chiu-Yan Tang ho-Yu Cheng connie Yuen-Yu Chong Wilson Wai-San Tam Wai-Tong Chien Sally Wai-Chi Chan The Nethersole School of Nursing Faculty of MedicineThe Chinese University of Hong KongHong Kong518172China School of Nursing and Midwifery College of HealthMedicine and WellbeingUniversity of NewcastleCallaghanNew South Wales2325Australia School of Nursing Tung Wah CollegeHong Kong200051China Alice Lee Centre for Nursing Studies National University of Singapore079903Singapore Tung Wah College Hong Kong200051China

The present study aimed to examine work environment related factors and frontline primary healthcare profes-sionals’mental-emotional wellbeing during the COVID-19 pandemic in school communities of hong Kong.A total of 61(20%)school health nurses(frontline primary healthcare professionals)participated in a cross-sec-tional online survey from March to June *** of mental-emotional health were measured using the Mental Health Continuum-Short Form(14-item scale with three subscales related to emotional,social and psychological wellbeing);the Perceived Stress Scale(10-item scale with two subscales related to perceived help-lessness and lack of self-efficacy);and the Coping Orientation to Problems Experienced Inventory(Brief COPE),a 28-item inventory with two subscales related to adaptive and maladaptive *** half(42.6%)of par-ticipants experienced mental health *** employed in government subsidized schools had signifi-cantly lower scores in mental health wellbeing than those who worked in private *** relating to increased mental health problems included lack of emotional support,inadequate training relating to infection prevention and control measures,disengagement and self-blame.A variety of factors inﬂuencing school health nurses’social,emotional and psychological wellbeing in their work environment during the COVID-19 pandemic were also *** mental-emotional wellbeing of school nurses may relate to their subjective feeling of lone-liness as participants were the sole frontline primary healthcare professional working in the school community during the COVID-19 *** provide relevant evidence for management teams to build a cul-ture of psychological and social support into workplace policies and *** staff development and adequate social support are important to promote the mental-emotional wellbeing of primary healthcare pro-fessionals in school communities as they play a significant

关键词： Primary healthcare professionals school nurses impact of COVID-19 pandemic stress coping mental health emotional wellbeing

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu Sherwin ho Michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

Prader-Willi Syndrome:16-Year Experience in hong Kong

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Journal of Genetics and Genomics 2012年第4期39卷 191-194页

作者： Ivan F.M. Lo ho Ming Luk luksite@*** Tony M.F. Tong Kent K.S. Lai Daniel H.C. Chan Albert C.F. Lam David K.H. Chan Edgar W.L. Hau connie O.Y. Fung Stephen T.S. Lam Clin Genet Serv Dept Hlth Kowloon Hong Kong Peoples R China

Prader-Willi syndrome （PWS） is an important, well-recognized syndromic form of neurodevelopmental disorder. The incidence is about 1 in 15,000-25,000 live births, and it affects both males and females （Vogels et al... 详细信息

关键词： PWS Prader-Willi Syndrome

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells(MSCs)

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Genes & Diseases 2021年第6期8卷 918-930页

作者： Yukun Mao Na Ni Linjuan Huang Jiaming Fan Hao Wang Fang He Qing Liu Deyao Shi Kai Fu Mikhail Pakvasa William Wagstaff Andrew Blake Tucker connie Chen Russell R.Reid Rex C.Haydon Sherwin H.ho Michael J.Lee Tong-Chuan He Jian Yang Le Shen Lin Cai Hue H.Luu Departments of Spine Surgery and Musculoskeletal Tumor and NeurosurgeryZhongnan Hospital of Wuhan UniversityWuhanHubei Province430072PR China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the School of Laboratory MedicineChongqing Medical UniversityChongqing400016PR China Departments of Nephrology and Obstetrics and GynecologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Department of Spine Surgery Second Xiangya HospitalCentral South UniversityChangshaHunan Province410011PR China Department of Orthopaedic Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei Province430022PR China Section of Plastic Surgery and Laboratory of Craniofacial Biology and Development and Section of Surgical ResearchDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Biomedical Engineering Materials Research InstituteThe Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA

As multipotent progenitor cells,mesenchymal stem cells(MSCs)can renew themselves and give rise to multiple lineages including osteoblastic,chondrogenic and adipogenic ***’s previously shown that BMP9 is the most potent BMP and induces osteogenic and adipogenic differentiation of ***,the molecular mechanism through which BMP9 regulates MSC differentiation remains poorly *** evidence indicates that noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone *** highly conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of the multi-protein RNA-induced silencing complexes(RISCs),which are critical for small RNA ***,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of *** first found that BMP9 upregulated the expression of Ago1,Ago2 and Ago3 in *** engineering multiplex siRNA vectors that express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found that silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline phosphatase(ALP)activity in ***,we demonstrated that simultaneously silencing all four Ago genes significantly diminished BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone ***,our findings strongly indicate that AGO proteins and associated small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs.

关键词： Argonaute(AGO)proteins BMP9 Bone formation Lineage-specific differentiation Mesenchymal stem cells miRNA biogenesis Osteogenic signaling