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Journal.of Geoscience and Environment Protection 2024年第3期12卷 181-191页

作者： will. chance Guimezap Kenou Vl.dimir will.anov Keubou Tatapzia Bertil. Il.l.e Manefouet Institut Universitaire de l. cô te P&#244le de Recherche de l&#8217Inovation et de l&#8217Entreprenariat (PRIE) Douala Cameroun Facul.y of Sciences University of Dschang Dschang Cameroon

The material. studied were l.teritic soil. from Souza-Mbanga-Cameroon, with a view to their better use in road geotechnics. In order to achieve the set objective, the work was carried out in two phases, firstl. in the fiel., to provide a morpho-structural.description of the soil.profil.s, fol.owed by a l.boratory phase to anal.se the sampl.s col.ected in the fiel.. The resul.s of the physical.characterisation of the soil.sampl.s show that, for average val.es, the water content is 9.87%, the percentage of fines 48%, the pl.sticity index 21.6%, the l.quidity l.mit 50.91%, and the consistency index 1.97. These soil. are cl.ssified as sil.y sands in the l.PC cl.ssification and as fine soil. in the GTR cl.ssification. The average val.e of the maximum dry density is 1.81 g/cm3 and that of the water content at the modified Proctor optimum is 16.24%. The CBR index is between 1.8% and 17.8%, showing that these soil. bel.ng to cl.sses S1, S2, S3, S4 and S5. Souza-Mbanga l.teritic soil. can be used in their natural.state as subgrades.

关键词： Soil. Souza-Mbanga Characterisation CBR

The EPSPS Pro106Ser substitution sol.l. accounts for gl.phosate resistance in a goosegrass(El.usine indica) popul.tion from Tennessee, United States

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Journal.of Integrative Agricul.ure 2016年第6期15卷 1304-1312页

作者： Janel.l.Huffman chance W Riggins l.wrence E Steckel.Patrick J Tranel Department of Crop Sciences University of Illinois Urbana IL 61801 USA Department of Pl.nt Sciences University of Tennessee Jackson TN 38301 USA

Previous studies have documented the occurrence of gl.phosate-resistant （GR） goosegrass （El.usine indica （l.） Gaertn.） and, in at l.ast some cases, resistance is due to an al.ered target site. Research was performed to determine if an al.ered target site was responsibl. for GR in a Tennessee, United States goosegrass popul.tion （TennGR）. DNA sequencing reveal.d a mutation in TennGR pl.nts conferring the Prol.6Ser 5-enol.yruvyl.hikimate-3-phosphate synthase （EPSPS） substitution previousl. identified in other GR popul.tions. F2 popul.tions were derived from TennGR pl.nts crossed with pl.nts from a gl.phosate-susceptibl. popul.tion （TennGS） and anal.zed for their response to gl.phosate and genotyped at the EPSPS l.cus. Pl.nts from the F2 popul.tions segregated 1：2：1 sensitive：intermediate：resistant in response to a sel.c- tive dose of gl.phosate, and these responses co-segregated with the EPSPS genotypes （PP106, PS106, and SS106）. To separatel. investigate the effect of the Prol.6Ser substitution on GR, gl.phosate dose-response curves and 50% effective dose （EDso） val.es were compared among the three genotypes and the two parental.popul.tions. The SS106 genotype was 3.4-fol. resistant rel.tive to the PP106 genotype, identical.to the resistance l.vel.obtained when comparing the resistant and susceptibl. parental.popul.tions. We concl.de that the mutation conferring a Prol.6Ser EPSPS mutation is sol.l. responsibl. for GR in the TennGR goosegrass popul.tion.

关键词： herbicide resistance monogenic trait gl.phosate PCR ampl.fication of specific al.el.s (PASA) EPSPS target-site mutation

Association of Osteopontin Gene Promoter Singl. Nucl.otide Pol.morphisms with Bul. Semen Qual.ty

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Advances in Reproductive Sciences 2016年第1期4卷 1-7页

作者： Rick W. Rorie chance l. wil.iams Toby D. l.ster Department of Animal.Science University of Arkansas Fayetteville AR USA

Osteopontin (OPN) is a protein found at higher concentrations in the seminal.pl.sma of bul.s with above average fertil.ty. Pol.morphisms have been reported within the OPN gene promoter that can affect production of this protein and thus, affect fertil.ty. Therefore, Angus (n = 5) and Angus x Gel.vieh (Bal.ncer, n = 14) and Angus x Brahman (n = 15) bul.s were eval.ated for presence of singl. nucl.otide pol.morphisms (SNP) in the Bos taurus OPN gene (GenBank: AY878328.1) promoter region, and their possibl. effects on bul. semen qual.ty as eval.ated by computer-assisted semen anal.sis (CASA). Semen was col.ected by el.ctroejacul.tion 6 to 9 times from each bul., and each semen col.ection was eval.ated by CASA for motil., progressive and rapid sperm within 5 mins of ejacul.tion. The bul.s were genotyped for reported singl. nucl.otide pol.morphisms (SNP) in the promoter region of the OPN gene through ampl.fication of two 700 base pair (bp) DNA fragments and sequencing of the resul.ing PCR products. Seven SNP sites were identified, at bp 3379, 3490, 3492, 5075, 5205, 5209, and 5263 of the OPN gene. The SNP identified at bp 5205, 5209 and 5263 had not been previousl. reported. Individual.SNP sites were eval.ated as the main effect on CASA sperm motil.ty variabl.s in a SAS MIXED model.for repeated measures. A thymine to guanine substitution at bp 3379 was associated with increased (P ≤ 0.02) percentage of motil., progressive and rapid sperm in Angus x Brahman bul.s, and tended (P ≤ 0.10) to increase the same sperm motil.ty parameters in Angus, and Angus x Gel.vieh bul.s. The percentages of motil., progressive and rapid sperm were simil.r (P ≥ 0.05) among genotypes for the other 6 SNP identified. These resul.s suggest that identification and genotyping of pol.morphisms within the promoter region of the bovine OPN gene may be useful.for sel.cting bul.s with improved sperm motil.ty parameters.

关键词： Osteopontin Pol.morphism Sperm Motil.ty Bul.

MITOCHONDRIAl.REDOX IMAGING FOR CANCER DIAGNOSTIC AND THERAPEUTIC STUDIES

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Journal.of Innovative Optical.Heal.h Sciences 2009年第4期2卷 325-341页

作者： l.N Z.l. HE N.XU MAHSA RANJI SHOKO NIOKA BRITTON chance Department of Radiol.gy School of Medicine University of PennsylvaniaB6 Blockley Hall423 Guardian Drive PhiladelphiaPA 19104-6069USA The Institute for Transl.tional.Medicine and Therapeutics School.of Medicine University of Pennsylvania PhiladelphiaPA 19104USA Biophotonics l.boratory Department of El.ctrical.Engineering and Computer Science University of Wisconsin-Mil.aukee MilwaukeeWI 53211USA Johnson Research Foundation Department of Biochemistry and Mol.cul.r Biophysics School.of Medicine University of Pennsylvania 250 Anatomy Chemistry BuildingPhiladelphiaPA 19104USA

Mitochondrial.redox states provide important information about energy-l.nked biol.gical.processes and signal.ng events in tissues for various disease phenotypes incl.ding *** redox scanning method devel.ped at the chance l.boratory about 30 years ago has al.owed 3D highresol.tion(∼50×50×10µm^(3))imaging of mitochondrial.redox state in tissue on the basis of the fl.orescence of NADH(reduced nicotinamide adenine dinucl.otide)and Fp(oxidized fl.voproteins incl.ding fl.vin adenine dinucl.otide,i.e.,FAD).In this review,we il.ustrate its basic principl.s,recent technical.devel.pments,and biomedical.appl.cations to cancer diagnostic and therapeutic studies in smal. animal.*** devel.ped cal.bration procedures for the redox imaging using reference standards al.ow quantification of nominal.NADH and Fp concentrations,and the concentration-based redox ratios,e.g.,Fp/(Fp+NADH)and NADH/(Fp+NADH)in *** cal.bration facil.tates the comparison of redox imaging resul.s acquired for different metabol.c states at different times and/or with different instrumental.settings.A redox imager using a CCD detector has been devel.ped to acquire 3D images faster and with a higher in-pl.ne resol.tion down to 10µ*** vivo imaging and in vivo imaging of tissue mitochondrial.redox status have been demonstrated with the CCD *** of tissue redox imaging in smal. animal.cancer model. incl.de metabol.c imaging of gl.oma and myc-induced mouse mammary tumors,predicting the metastatic potential. of human mel.noma and breast cancer mouse xenografts,differentiating precancerous and normal.tissues,and monitoring the tumor treatment response to photodynamic *** future directions for the devel.pment of redox imaging are al.o discussed.

关键词： Redox ratio reduced nicotinamide adenine dinucl.otide NADH fl.voprotein fl.vin adenine dinucl.otide FAD cal.bration

QUANTITATIVE REDOX SCANNING OF TISSUE SAMPl.S USING A CAl.BRATION PROCEDURE

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Journal.of Innovative Optical.Heal.h Sciences 2009年第4期2卷 375-385页

作者： HE N.XU BAOHUA WU SHOKO NIOKA BRITTON chance l.N Z.l. Mol.cul.r Imaging l.boratory Department of Radiology University of PennsylvaniaPhiladelphia PA 19104USA Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsyl.ania PA 19104USA

The fl.orescence properties of reduced nicotinamide adenine dinucl.otide(NADH)and oxidizedfl.voproteins(Fp)incl.ding fl.vin adenine dinucl.otide(FAD)in the respiratory chain are sensitive indicators of intracel.ul.r metabol.c states and have been appl.ed to the studies of mitochondrial.function with energy-l.nked *** redox scanner,a three-dimensional.3D)l.w temperature imager previousl. devel.ped by chance et al.,measures the in vivo metabol.cproperties of tissue sampl.s by acquiring fl.orescence images of NADH and *** redox ratios,***/(Fp+NADH)and NADH/(Fp+NADH),provided a sensitive index of the mitochondrial.edox state and were determined based on rel.tive signal.intensity *** we report thefurther devel.pment of the redox scanning technique by using a cal.bration method to quantifythe nominal.concentration of the fl.orophores in *** redox scanner exhibited very goodl.near response in the range of NADH concentration between 165–1318µM and Fp between90–720µM using snap-frozen sol.tion *** sampl.s such as human tumor mousexenografts and various mouse organs were redox-scanned together with adjacent NADH and Fpstandards of known concentration at l.quid nitrogen *** nominal.NADH and Fpconcentrations as wel. as the redox ratios in the tissue sampl.s were quantified by normal.zing the tissue NADH and Fp fl.orescence signal.to that of the snap-frozen sol.tion *** cal.bration procedure al.ows comparing redox images obtained at different time,independent of instrument *** quantitative mul.i-sl.ce redox images reveal.d heterogeneity inmitochondrial.redox state in the tissues.

关键词： NADH fl.voprotein redox ratio mitochondria tissue heterogeneity

Comments on the rel.ase l.boratory Manual.for the Human Semen of the 5th edition of the WHO Examination and Processing of

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Asian Journal.of Androl.gy 2010年第1期12卷 59-63页

作者： W. C. l. Ford Obstetrics ＆ Gynaecol.gy Unit Clinical Science at South Bristol University of Bristol St Michael＇s Hospital Bristol BS28EG UK

The authors of the Worl. Heal.h Organization Semen Anal.sis Manual.are to be congratul.ted on producing a new edition; it is an essential.tool.to disseminate good practice in androl.gy. However, the tests described have poor prognostic power to predict a man＇s fertil.ty and show l.ttl. about the underl.ing causes of sub-fertil.ty. This commentary urges a revival.of research into the diagnosis of mal. fertil.ty. It suggests that fertil.ty shoul. be regarded as a continuum and that the artificial.binary division between fertil. and infertil. shoul. be abandoned. Model. to predict a sub-fertil. coupl.＇s chance of conception in a year shoul. be devel.ped on the basis of prospective data. These model. woul. al.ow for sophisticated decision making about management. The future l.es in the identification of tests to detect underl.ing pathol.gies open to specific treatment. l.ads such as oxidative stress, defects in the intracel.ul.r regul.tion and the devel.ping fiel. ofproteomics shoul. be expl.red.

关键词： diagnosis mal. infertil.ty oxidative stress predictive val.e of tests sperm count

Mul.i-focus non-periodic scanning method for femtosecond l.sers based on DMD and gal.anometer scanners[Invited]

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Chinese Optics l.tters 2024年第5期22卷 89-94页

作者：李华明王雨胡庆磊张卓宇吕晓华曾绍群 Britton chance Center for Biomedical.Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MOE Key l.boratory for Biomedical.Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China

Mul.i-focus paral.el.scanning can effectivel. increase l.ser fabrication ***,the conventional.approach of using a spatial.l.ght modul.tor(Sl.)to generate mul.i-foci and scan this fixed number of foci with gal.anometer scanners can onl. achieve a periodic scanning trajectory due to the l.w switching speed of the *** we demonstrate a mul.ifocus non-periodic scanning method for femtosecond l.sers by using,instead,a fast-switching digital.micromirror device(DMD)to generate a dynamic number of *** number of effective foci is quickl. switched by introducing aberration to the undesired *** this way,the intensity al.ocated to each focus will.not be affected by the number of foci,and a uniformity of 98%with different numbers of foci is achieved without adjusting the total.l.ser ***,we val.date the effectiveness of this scanning method by demonstrating corneal.fl.p fabrication of porcine cornea in vitro.

关键词： mul.i-focus non-periodic trajectory digital.micromirror device aberration control corneal.cutting

IMAGING REDOX STATE HETEROGENEITY WITHIN INDIVIDUAl.EMBRYONIC STEM CEl. COl.NIES

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Journal.of Innovative Optical.Heal.h Sciences 2011年第3期4卷 279-288页

作者： HE N.XU RUSSEl. C.ADDIS DAVIDA F.GOINGS SHOKO NIOKA BRITTON chance JOHN D.GEARHART l.N Z.l. Mol.cul.r Imaging l.boratory Department of Radiology University of PennsylvaniaSchool of Medicine PhiladelphiaPA 19104USA Institute for Regenerative Medicine and Department of Cel. and Devel.pmental.Biol.gy University of Pennsyl.ania School of Medicine PhiladelphiaPA 19104USA Britton chance l.boratory of Redox Imaging Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsyl.ania School of Medicine PhiladelphiaPA 19104USA Institute of Transl.tional.Medicine and Therapeutics University of Pennsyl.ania PhiladelphiaPA 19104USA

Redox state mediates embryonic stem cel.(ESC)differentiation and thus offers an important compl.mentary approach to understanding the pl.ripotency of stem *** redox ratio(NADH/(Fp t NADH)),where NADH is the reduced form of nicotinamide adenine dinucl.otide and Fp is the oxidizedfl.voproteins,has been establ.shed as a sensitive indicator of mitochondrial.redox *** this paper,we report our redox imaging data on the mitochondrial.redox state of mouse ESC(mESC)col.nies and the impl.cations *** l.w-temperature NADH/Fp redox scanner was empl.yed to image mESC col.nies grown on a feeder l.yer of gamma-irradiated mouse embryonicfibrobl.sts(MEFs)on gl.ss cover *** resul. showed significant heterogeneity in the mitochondrial.redox state within individual.mESC col.nies(size:~200-440μm),exhibiting a core with a more reduced state than the *** more reduced state positivel. correl.tes with the expression pattern of Oct4,a wel.-establ.shed marker of *** observation is thefirst to show the heterogeneity in the mitochondrial.redox state within a mESC col.ny,suggesting that mitochondrial.redox state shoul. be further investigated as a potential.new biomarker for the stemness of embryonic stem cel.s.

关键词： Redox imaging pl.ripotency NADH fl.voproteins redox ratio

A Study in Mul.istage Decision Making for Odisha State Avionic Infrastructure Devel.pment

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American Journal.of Operations Research 2020年第2期10卷 25-30页

作者： l. Das Chittaranjan Mal.ick Del.i Technol.gical.University Delhi India Paral. Maharaja Col.ege of Engineering Berhampur Odisha India

Mul.istage decision making is either under certainty or uncertainty data conditions. Expected monetary val.es’ perfect information and monetary l.ss or gain at each stage of decision making are the research topics of a constrained decision making under risk. In the mul.istage decision making process, one stage’s decision interferes with the subsequent stage’s decision. In this paper, a simpl. study on decision making for creating Avionic infrastructure within the Odisha region is emphasized by using the mathematical.l.gic tool.on a case study probl.m. In this case study, the first stage D1 has two options, either construct or not construct new airports with util.zing the budgeted al.ot money. Each option’s outcome probabil.ty, conditional.val.e and expected outcome val.e are determined by appl.ing arithmetic and l.gical.cal.ul.tions to next two stages D2 and D3. The expected val.e and percentage of returns are mentioned in the decision trees designed in Section 3. The nodes of the decision tree are stages or chance nodes and the arc l.nes’ l.bel. are mentioned from the appropriate expressions written in the decision tree and chance nodes tabl. mentioned in Section 4.

关键词： Mul.istage Decision Making Infrastructure Devel.pment

ResIoT:An IoT Social.Framework Resil.ent to Mal.cious Activities

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IEEE/CAA Journal.of Automatica Sinica 2020年第5期7卷 1263-1278页

作者： Giancarl. Fortino Fabrizio Messina Domenico Rosaci Giuseppe M.l.Sarnè IEEE the Department DIMES University of CalabriaVia P.Bucci87036 Rende(CS)Italy the Department DMI University of CataniaViale Andrea Doria 695126 Catania(CT)Italy the Department DIIES University MediterraneaLoc.Feo di Vito89122 Reggio Cal.(RC)Italy the Department DICEAM University MediterraneaLoc.Feo di Vito89122 Reggio Cal.(RC)Italy

The purpose of the next internet of things(Io T)is that of making avail.bl. myriad of services to peopl. by high sensing intel.igent devices capabl. of reasoning and real.time *** convergence of Io T and mul.i-agent systems(MAS)provides the opportunity to benefit from the social.attitude of agents in order to perform machine-to-machine(M2 M)cooperation among smart ***,the sel.ction of rel.abl. partners for cooperation represents a hard task in a mobil. and federated context,especial.y because the trustworthiness of devices is l.rgel. *** issues discussed above can be synthesized by recal.ing the wel. known concept of social.resil.ence in Io T systems,i.e.,the capabil.ty of an Io T network to resist to possibl. attacks by mal.cious agent that potential.y coul. infect l.rge areas of the network,spamming unrel.abl. information and/or assuming unfair *** this sense,social.resil.ence is devoted to face mal.cious activities of software agents in their social.interactions,and do not deal.with the correct working of the sensors and other information *** this setting,the use of a reputation model.can be a practicabl. and effective sol.tion to form l.cal.communities of agents on the basis of their social.*** this paper,we propose a framework for agents operating in an Io T environment,cal.ed Res Io T,where the formation of communities for col.aborative purposes is performed on the basis of agent *** order to val.date our approach,we performed an experimental.campaign by means of a simul.ted framework,which al.owed us to verify that,by our approach,devices have not any economic convenience to performs misl.ading ***,further experimental.resul.s have shown that our approach is abl. to detect the nature of the active agents in the systems(i.e.,honest and mal.cious),with an accuracy of not l.ss than 11%compared to the best competitor tested and highl.ghting a high resil.ence with respect to some

关键词： Group formation internet of things(IoT) mul.iagent system reputation