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Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

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Journal of Pharmaceutical Analysis 2022年第4期12卷 530-540页

作者： Rui-Lin Liu Ru-qian cai School of Pharmacy Xuzhou Medical UniversityXuzhou221004China Department of Pharmaceutical Analysis School of PharmacyXi'an Jiaotong UniversityXi'an710061China

Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical *** recently developed ultrasound-controlled fluorescence(UCF)imaging is a novel imaging technique that can overcome this *** studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in ***,this review highlights the recent advances(2015e2020)in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep *** imaging performances of various UCF systems,including the signal-to-noise ratio,imaging resolution,and imaging depth,are specifically *** addition,the challenges and prospects are *** continuously increasing research interest in this field and emerging multidisciplinary applications,UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly,which is expected to have a far-reaching impact on disease surveillance and/or therapy.

关键词： Ultrasound-controlled fluorescence imaging Temperature-sensitive NIR probes High-resolution Deep tissue Molecular diagnosis

A method for detecting miners based on helmets detection in underground coal mine videos

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Mining Science and Technology 2011年第4期21卷 553-556页

作者： cai Limei qian Jiansheng School of Information and Electrical Engineering China University of Mining ＆ Technology Xuzhou 221116 China

In order to monitor dangerous areas in coal mines automatically,we propose to detect helmets from underground coal mine videos for detecting *** method can overcome the impact of similarity between the targets and their *** constructed standard images of helmets,extracted four directional features,modeled the distribution of these features using a Gaussian function and separated local images of frames into helmet and non-helmet *** experimental results show that this method can detect helmets *** detection rate was 83.7%.

关键词： Human detection Helmet detection Coal mine Gaussian model Image pattern recognition

EEG-based Emotion Recognition Using Multiple Kernel Learning

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Machine Intelligence Research 2022年第5期19卷 472-484页

作者： qian cai Guo-Chong Cui Hai-Xian Wang School of Statistics and Data Science Nanjing Audit UniversityNanjing 211815China Key Laboratory of Child Development and Learning Science of Ministry of Education School of Biological Science&Medical EngineeringSoutheast UniversityNanjing 210096China Institute of Artificial Intelligence of Hefei Comprehensive National Science Center Hefei 230094China

Emotion recognition based on electroencephalography(EEG)has a wide range of applications and has great potential value,so it has received increasing attention from academia and industry in recent ***,multiple kernel learning(MKL)has also been favored by researchers for its data-driven convenience and high ***,there is little research on MKL in EEG-based emotion ***,this paper is dedicated to exploring the application of MKL methods in the field of EEG emotion recognition and promoting the application of MKL methods in EEG emotion ***,we proposed a support vector machine(SVM)classifier based on the MKL algorithm EasyMKL to investigate the feasibility of MKL algorithms in EEG-based emotion recognition *** designed two data partition methods,random division to verify the validity of the MKL method and sequential division to simulate practical ***,tri-categorization experiments were performed for neutral,negative and positive emotions based on a commonly used dataset,the Shanghai Jiao Tong University emotional EEG dataset(SEED).The average classification accuracies for random division and sequential division were 92.25%and 74.37%,respectively,which shows better classification performance than the traditional single kernel *** final results show that the MKL method is obviously effective,and the application of MKL in EEG emotion recognition is worthy of further *** the analysis of the experimental results,we discovered that the simple mathematical operations of the features on the symmetrical electrodes could not effectively integrate the spatial information of the EEG signals to obtain better *** is also confirmed that higher frequency band information is more correlated with emotional state and contributes more to emotion *** summary,this paper explores research on MKL methods in the field of EEG emotion recognition and provides a new way of thinking for EE

关键词： Emotion recognition electroencephalography(EEG) multiple kernel learning machine learning brain computer interface

Chemical components and protective effects of Atractylodes japonica *** Kitam against acetic acid-induced gastric ulcer in rats

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World Journal of Gastroenterology 2023年第43期29卷 5848-5864页

作者： Bi-Xian Zhen qian cai Feng Li Department of Medicine Liaoning University of Traditional Chinese MedicineDalian 116600Liaoning ProvinceChina

BACKGROUND Atractylodes japonica *** Kitam.(***,Chinese name:Guan-Cangzhu,Japanese name:Byaku-jutsu),a perennial herb,which is mainly distributed in northeast area of China,it’s often used to treat digestive system diseases such as gastric ulcer(GU).However,the mechanism of its potential protective effects against GU remains *** To investigate the protective effects of *** on acetic acid-induced GU *** The chemical constituents of *** were determined by ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS)*** rat model of GU was simulated by acetic acid *** pathological changes of gastric tissues were evaluated by hematoxylin-eosin stain,the levels of epidermal growth factor(EGF),EGF receptor(EGFR),nuclear factor kappa-B(NF-κB),interleukin-1β(IL-1β),IL-10,Na^(+)-K^(+)-ATPase(NKA)in serum and gastric tissues were determined by enzyme-linked immunosorbent assay,and the mRNA expressions of EGFR,NF-κBp65,IkappaBalpha(IκBα)and Zonula Occludens-1(ZO-1)in gastric tissues were determined by real-time reverse transcription polymerase chain reaction,and the efficacy was ***,plasma metabolomic analysis was performed by UPLC-MS/MS to screen the specific potential biomarkers,metabolic pathways and to explore the possible *** 48 chemical constituents were *** of them have strong pharmacological activity,the results also revealed that *** significantly improved the pathological damage of gastric tissues,increased the expression levels of IL-10,IκBαrelated to anti-inflammatory factors,decreased the expression levels of IL-1β,NF-κB,NF-κBp65,related to proinflammatory factors,restored the levels of factors about EGF,EGFR,ZO-1 associated with ulcer healing and the levels of factors about NKA associated with energy *** analysis identified 10 potential differential metabolites and enriched 7 related metabolic *** These findings

关键词： Atractylodes japonica Koidz.ex Kitam. Ulcer Acetic acid Digestive system diseases Metabolomics Rats

Synthesis of 1-Aryl-1 H-indazoles via a Ligand-Free Copper- Catalyzed Intramolecular Amination Reaction

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Chinese Journal of Chemistry 2011年第6期29卷 1199-1204页

作者： Gao, Mingshan Liu, Xiujie Wang, Xianyang cai, qian Ding, Ke Key Laboratory of Regenerative Biology and Institue of Chemical Biology Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Guangdong 510530 China Jiangsu Provincial Institute of Materia Medica Nanjing University of Technology Nanjing Jiangsu 210009 China

A general synthesis of 1-aryl-l-H-indazoles from o-halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand-free copper-catalyzed intramolecular Ullmann-type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.

关键词： copper amination ligand free

Transparent Co_(3)FeO_(x) Film Passivated BiVO_(4) Photoanode for Efficient Photoelectrochemical Water Splitting

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Chinese Journal of Structural Chemistry 2021年第11期40卷 1505-1512,1409页

作者： FANG Ming QIN Qi cai qian LIU Wei Fujian Normal University Fuzhou 350007China CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of NanomaterialFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Photoelectrochemistry that use semiconductors to absorb sunlight for water splitting provides an effective method for the development of renewable hydrogen energy in the *** this paper,a transparent and highly-efficient cobalt-iron oxide(Co_(3)FeO_(x))nano-film was fabricated through hydrothermal method by directional adjustment of atomic ratio to promote the kinetics of BiVO_(4)(BVO)photoanode water *** a result,the Co_(3)FeO_(x)-modified BVO photoanode(Co_(3)FeO_(x)/BVO)exhibits an impressive photocurrent density of 4.0 mA·cm^(2) at 1.23 V versus reversible hydrogen electrode(RHE),approximately 2.17-fold higher than that of bare BVO,as well as a cathodically shifted onset potential of 320 *** catalyst nanolayer structure is clarified by ultraviolet-visible *** addition,the Co_(3)FeO_(x)/BVO photoanode has better stability,and there is no obvious activity degradation after 10 hours of *** strategy provides a broad prospect for the use of water oxidation co-catalyst to achieve effective water splitting.

关键词： photoelectrochemical water splitting bismuth vanadate co-catalyst cobalt-iron oxide

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Responses of Soil Micro-Food Web to Land Use Change from Upland to Paddy Fields with Different Years of Rice Cultivation

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Pedosphere 2017年第1期27卷 155-164页

作者： LU Ying BAI Wei WANG Xuefeng cai qian LIANG Wenju Liaoning Key Laboratory of Soil Environmental Quality and Agro-Product Safety Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 (China) Tillage and Cultivation Research Institute Liaoning Academy of Agricultural Sciences Shenyang 110161 (China) Northeast Institute of Geography and Agroecology Key Laboratory of Wetland Ecology and Environment Chinese Academy of Sci-ences Changchun 130102 (China) University of Chinese Academy of Sciences Beijing 100049 (China)

Land use changes affect belowground *** the past few decades,land use in Northeast China has changed considerably,and the area of paddy fields has increased rapidly from *** this study,soil characteristics and soil biotic community in paddy fields with different years of rice cultivation were measured to examine the effects of land use change from upland to paddy fields on soil micro-food *** upland maize fields were selected as control and the microbial community composition was characterized using phospholipid fatty acids(PLFAs) *** microbial biomass(total PLFA),bacteria biomass,and fungi biomass were higher in the 20-40-year(late-stage) than 1-10-year(early-stage) paddy *** abundances of total nematodes and bacterivores were lower in the early-stage than late-stage paddy *** abundance of herbivores was the highest in the early-stage paddy fields but that of omnivore-predators was the highest in the late-stage paddy *** equation model indicated that soil food web was developed and structured after 20 years of paddy *** results suggested that soil micro-food web may be a good indicator for soil development and stabilization of paddy fields following land use change.

关键词： belowground ecosystem microbial community composition phospholipid fatty acids soil nematodes structural equationmodel

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学四诊之法把结构之脉

中国中医药现代远程教育 2025年第1期23卷 95-98页

作者：曲扬窦德强王丽娜才谦辽宁中医药大学药学院辽宁大连116600

为解决中药化学课程教学中,因中药化学成分结构复杂、结构鉴定难度大导致学生较难掌握的问题,借鉴中医“四诊”之法的整体观,构建“四诊法”教学。即在讲授中药化学成分结构鉴定内容时,借鉴“望、闻、问、切”四诊之法,综合分析其成分... 详细信息

为解决中药化学课程教学中,因中药化学成分结构复杂、结构鉴定难度大导致学生较难掌握的问题,借鉴中医“四诊”之法的整体观,构建“四诊法”教学。即在讲授中药化学成分结构鉴定内容时,借鉴“望、闻、问、切”四诊之法,综合分析其成分的来源与结构类型、性质与结构特点、波谱特征与结构取代情况之间的关系,培养学生综合理解和运用所学知识解决实际问题的能力。该法分析中药化学成分结构鉴定的相关信息,依照望、闻、问、切的次序,抽丝剥茧地解析出化合物结构,有助于学生理解中药化学成分结构鉴定的过程和意义。将此法应用于中药化学成分结构鉴定课程教学中,将中医整体观与现代科学研究结果有机结合,可解决教学重难点问题,有助于培养学生的中医药思维和科学思维。

关键词：四诊法结构鉴定中药化学

SmartPipe: Towards Interoperability of Industrial Applications via Computational Reflection

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Journal of Computer Science & Technology 2020年第1期35卷 161-178页

作者： Su Zhang Hua-qian cai Yun Ma Tian-Yue Fan Ying Zhang Gang Huang Key Laboratory of High-Confidence Software Technology(Peking University) Ministry of Education Beijing 100871China School of Software Tsinghua UniversityBeijing 100084China Hengyi Petrochemicals CO. LTD.Hangzhou 311215China National Engineering Research Center for Software Engineering Peking UniversityBeijing 100871China

With the advancement of new information technologies,a revolution is being taken place to bring the industry into a new era of intelligent *** of the key requirements of intelligent manufacturing is the interoperability of industrial ***,it is challenging to realize the interoperability for legacy industrial applications due to 1)the deficient semantic information of data transmitted over heterogeneous communication protocols,2)the difficulty to understand the complex process of business logic with no source code,and 3)the high cost and potential risk of reengineering the *** address the issues,in this paper,we propose an approach named SmartPipe to exposing existing functionalities of an industrial application as APIs without source code while simultaneously allowing the application to remain *** design a behavioral runtime model(BRM)as the self-representation of the industrial applications,based on which a computational reflection framework is designed to flexibly construct the model and generate APIs that encapsulate specific *** validate SmartPipe on a real industrial application that controls the spin-draw winding *** show that our approach is effective and more suitable for industrial scenes compared with traditional approaches.

关键词： computational reflection runtime model interoperability industrial application API generation