Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging
作者机构：School of PharmacyXuzhou Medical UniversityXuzhou221004China Department of Pharmaceutical AnalysisSchool of PharmacyXi'an Jiaotong UniversityXi'an710061China
出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)
年 卷 期：2022年第12卷第4期
页 面：530-540页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 08[工学]
基 金：supported by the National Natural Science Foundation of China(Grant No.:81703466) the Outstanding Talents Research Start-up Fund of Xuzhou Medical University,China(Grant No.:RC20552107) Xuzhou Science and Technology Bureau,China(Grant No.:KC21292).
主 题：Ultrasound-controlled fluorescence imaging Temperature-sensitive NIR probes High-resolution Deep tissue Molecular diagnosis
摘 要：Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical radiation.The recently developed ultrasound-controlled fluorescence(UCF)imaging is a novel imaging technique that can overcome this bottleneck.Previous studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo.Here,this review highlights the recent advances(2015e2020)in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues.The imaging performances of various UCF systems,including the signal-to-noise ratio,imaging resolution,and imaging depth,are specifically discussed.In addition,the challenges and prospects are highlighted.With continuously increasing research interest in this field and emerging multidisciplinary applications,UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly,which is expected to have a far-reaching impact on disease surveillance and/or therapy.
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