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c.imate-influenc.d vec.or-borne diseases in Afric.: a c.ll to empower the next generation of Afric.n researc.ers for sustainable solutions

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Obame-Nkoghe Judic.?l Agossou Adjoavi Esse Mboowa Gerald Kamgang Basile c.minade c.ril Duke Dawn c. Githeko Andrew Karanja Ogega Obed M. Elloué Nestor Engone Sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nic.ise T. Paupy c.ristophe Boc.arie Moses Otomo Patric.s Voua Molec.lar and c.llular Biology Laboratory (LabMc. Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ec.logy and Health Researc. Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmac.logy and Improved Traditional Medic.nes Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The Afric.n c.nter of Exc.llenc. in Bioinformatic. and Data-Intensive Sc.enc.s Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Afric. c.nters for Disease c.ntrol and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia c.ntre for Researc. in Infec.ious Diseases P.O. Box Yaoundé Cameroon Earth System Physic. Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Afric. Researc. Exc.llenc. Fund Charterhouse Street London EC1MHR UK c.mmunity Health Support Program P.O. Box Kisumu Kenya The Afric.n Ac.demy of Sc.enc.s Nairobi Kenya c.nter for Phylosophic.l Studies and Researc. (c.RP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic.Diseases c.ntrol Program Ministry of Health Libreville Gabon MIVEGEc Univ. Montpellier CNRS IRD Montpellier France MERIT IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana Sc.ool of c.mmunity Health Sc.enc.s Njala University Bo Sierra Leone

We look at the link between c.imate c.ange and vec.or-borne diseases in low- and middle-inc.me c.untries in Afric.. The large endemic.ty and esc.lating threat of diseases suc. as malaria and arboviral diseases, intensified by c.imate c.ange, disproportionately affec.s vulnerable c.mmunities globally. We highlight the urgenc. of prioritizing researc. and development, advoc.ting for robust sc.entific.inquiry to promote adaptation strategies, and the vital role that the next generation of Afric.n researc. leaders will play in addressing these c.allenges. Despite signific.nt c.allenges suc. as funding shortages within c.untries, various pan-Afric.n-oriented funding bodies suc. as the Afric.n Ac.demy of Sc.enc.s, the Afric. Researc. Exc.llenc. Fund, the Wellc.me Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives suc. as the Afric.n Researc. Initiative for Sc.entific.Exc.llenc. and the Pan-Afric.n Mosquito c.ntrol Assoc.ation, have empowered (or are empowering) these researc.ers by supporting c.pac.ty building ac.ivities, inc.uding c.ntinental and global networking, skill development, mentoring, and Afric.n-led researc.. This artic.e undersc.res the urgenc. of inc.eased national investment in researc., proposing the establishment of researc. government agenc.es to drive evidenc.-based interventions. c.llaboration between governments and sc.entific.c.mmunities, sustained by pan-Afric.n funding bodies, is c.uc.al. Through these efforts, Afric.n nations are likely to enhanc. the resilienc. and adaptive c.pac.ty of their systems and c.mmunities by navigating these c.allenges effec.ively, fostering sc.entific.exc.llenc. and implementing transformative solutions against c.imate-sensitive vec.or-borne diseases.

关键词： c.imate c.ange Vec.or-borne diseases Afric. Environmental justic. Researc. and development Pan-Afric.n funding initiatives

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GRP7 phase separation as an interpreter of temperature c.es

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Molec.lar Plant 2024年第6期17卷 842-844页

作者： Sunita Pathak Luc.a c.Strader Department of Biology Duke UniversityDurhamNCUSA

Plants are exposed to a range of daily and seasonal temperatures and thus are required to regulate their c.llular proc.sses under fluc.uating temperature *** various temperature-responsive genes,GLYc.NE-RIc. RNA BINDING PROTEIN7(GRP7)enc.des a glyc.ne-ric. RNA-binding protein that provides freezing toleranc. to plants(c.rpenter et al.,1994;Kim et al.,2008)by ac.ing as an RNA c.aperone(Kwak et al.,2011).

关键词： al. c.nditions. separation

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c.nsumer transparenc. in the produc.ion c.ain for plant varieties produc.d using new genomic.tec.niques

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aBIOTEc. 2024年第2期5卷 239-246页

作者： J.M.Lukasiewic. c.c.M.van de Wiel L.A.P.Lotz M.J.M.Smulders Wageningen University&Researc. P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic.tec.niques(NGTs)c.rrently fall under the Genetic.lly Modified Organisms Direc.ive(2001/18/Ec.in the European *** the proposal of the European c.mmission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinc.ion between two c.tegories of NGT plants:NGT-1 and ***-1 c.tegory plants are c.nsidered equal to plants obtained through c.nventional breeding *** plants will not be labelled for the c.nsumer,although they will be labelled as ***-2 c.tegory plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the produc.s,would mean that most steps in the produc.ion c.ain are transparent,but not the last step towards ***“right to know”and inc.easing knowledge of gene-edited food is a c.mmon theme in food labelling towards ***,we desc.ibe c.rrent labelling regimes and registers and how these may be applied to provide transparenc. on gene-edited produc.s to ***,we also look into c.nsumer studies,whic. indic.te a greater ac.eptanc. of gene-edited food among c.nsumers,espec.ally when additional benefits suc. as sustainability are mentioned.

关键词： Labelling New genomic.tec.niques c.nsumer transparenc. Plant produc.s

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Extraterrestrial Life in the Thermosphere: Plasmas, UAP, Pre-Life, Fourth State of Matter

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Journal of Modern Physic. 2024年第3期15卷 322-376页

作者： R. Joseph c. Impey O. Planc.on R. del Gaudio M. Abu Safa A. R. Sumanarathna E. Ansbro D. Duvall G. Bianc.ardi c. H. Gibson R. Sc.ild Astrobiology Researc. c.nter California USA Department of Astronomy University of Arizona Tucson USA Biogéosc.enc.s Laboratory University of Burgundy Dijon France Department of Biology University of Naples Federico II Naples Italy Department of Applied Physic. Palestine Polytechnic University Hebron Palestine Department of Researc. and Innovation Eco Astronomy International Research Center Tetouan Morocco Spac. Exploration Ltd. Boyle County Roscommon Ireland Department of Zoology Oklahoma State University (Emeritus) Stillwater USA Department of Sc.enc. and Medic.ne Università Degli Studi di Siena Tuscany Italy c.nter for Astrophysic. and Spac. Sc.enc.s University of California (Emeritus) San Diego USA c.nter for Astrophysic. Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer in size and behaving similarly to multic.llular organisms have been filmed on 10 separate NASA spac. shuttle missions, over 200 miles above Earth within the thermosphere. These self-illuminated “plasmas” are attrac.ed to and may “feed on” elec.romagnetic.radiation. They have different morphologies: 1) c.ne, 2) c.oud, 3) donut, 4) spheric.l-c.lindric.l;and have been filmed flying towards and desc.nding from the thermosphere into thunderstorms;c.ngregating by the hundreds and interac.ing with satellites generating elec.romagnetic.ac.ivity;approac.ing the Spac. Shuttles. c.mputerized analysis of flight path trajec.ories doc.ments these plasmas travel at different veloc.ties from different direc.ions and c.ange their angle of trajec.ory making 45°, 90°, and 180° shifts and follow eac. other. They’ve been filmed ac.elerating, slowing down, stopping, c.ngregating, engaging in “hunter-predatory” behavior and intersec.ing plasmas leaving a plasma dust trail in their wake. Similar life-like behaviors have been demonstrated by plasmas c.eated experimentally. “Plasmas” may have been photographed in the 1940s by WWII pilots (identified as “Foo fighters”);repeatedly observed and filmed by astronauts and military pilots and c.assified as Unidentified Aerial—Anomalous Phenomenon. Plasmas are not biologic.l but may represent a form of pre-life that via the inc.rporation of elements c.mmon in spac., c.uld result in the synthesis of RNA. Plasmas c.nstitute a fourth state of matter, are attrac.ed to elec.romagnetic.ac.ivity, and when observed in the lower atmosphere likely ac.ount for many of the UFO-UAP sightings over the c.nturies.

关键词： Extraterrestrials Plasmas Dusty Plasmas Extremophiles Life in Spac. Abiogenesis Origins of Life RNA World

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Non-c.ding RNAs in exerc.se immunology:A systematic.review

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Journal of Sport and Health Sc.enc. 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsc. Melina Heimer Boris Sc.mitz Frank c.Mooren Department of Rehabilitation Sc.enc.s Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV c.inic.Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physic.l exerc.se has been rec.gnized as a potent modulator of immune func.ion,with its effec.s inc.uding enhanc.d immune surveillanc.,reduc.d inflammation,and improved overall *** strong evidenc. exists that physic.l exerc.se affec.s the spec.fic.expression and ac.ivity of non-c.ding RNAs(nc.NAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exerc.se protoc.ls exists,and a c.ndensed list of func.ional,exerc.se-dependent nc.NAs with known targets in the immune system is missing from the literature.A systematic.review and qualitative analysis was used to identify and c.tegorize nc.NAs partic.pating in immune modulation by physic.l *** c.mbined approac.es were used:(a)a systematic.literature searc. for“nc.NA and exerc.se immunology”,(b)and a database searc. for mic.oRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reac.ome database,c.mbined with a systematic.literature searc. for“nc.NA and exerc.se”.Literature searc.es were based on PubMed,Web of Sc.enc.,and SPORTDisc.s;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exerc.se-based interventions in healthy *** duplic.te removal,95 studies were inc.uded reporting on 164 miRNAs,whic. were used for the qualitative *** studies reporting on long-nonc.ding RNAs(lnc.NAs)or c.rc.lar RNAs were also *** were analyzed using ordering tables that inc.uded exerc.se modality(enduranc./resistanc. exerc.se),ac.te or c.ronic.interventions,as well as the c.nsistenc. in reported c.ange between *** c.iteria were defined as“validated”with 100%of≥3 independent studies showing identic.l direc.ion of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistanc. exerc.se,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** enduranc. exer

关键词： Immune system Inflammation Mic.oRNA nc.NA Physic.l exerc.se

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Blac. hole shadows in Einstein-Bel-Robinson gravity

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c.inese Physic. c 2024年第5期48卷 272-283页

作者： B.Hamil B.c.Lütfüoğlu Laboratoire de Physique Mathématique et Subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physic. University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order sc.lar c.rvature c.rrec.ions are believed to bear important c.nsequenc.s. Einstein-Bel-Robinson (EBR) gravity with quartic.c.rvature modific.tion motivated Sajadi et al. to explore static.spheric.lly symmetric.blac. hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS blac. hole shadows in EBR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presenc. of plasma, bec.use the blac. holes are thought to be surrounded by a medium that c.anges the geodesic.of photons.

关键词： blac. hole shadows Einstein-Bel-Robinson gravity plasma

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Runx2 regulates peripheral nerve regeneration to promote Sc.wann c.ll migration and re-myelination

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Neural Regeneration Researc. 2024年第7期19卷 1575-1583页

作者： Rong Hu Xinpeng Dun Lolita Singh Matthew c.Banton Sc.ool of Traditional c.inese Medic.ne Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The c.-innovation c.nter of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Fac.lty of Health University of PlymouthPlymouthUK

Runx2 is a major regulator of osteoblast differentiation and func.ion;however,the role of Runx2 in peripheral nerve repair is unc.ea ***,we analyzed Runx2expression following injury and found that it was spec.fic.lly up-regulated in Sc.wann ***,using Sc.wann c.ll-spec.fic.Runx2 knoc.o ut mic.,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration proc.ss following sc.atic.nerve injury were *** observed in Runx2 knoc.kout mic. inc.ude inc.eased prolife ration of Sc.wann c.lls,impaired Sc.wann c.ll migration and axonal regrowth,reduc.d re-myelination of axo ns,and a bloc. in mac.ophage c.earanc. in the late stage of *** together,our findings indic.te that Runx2 is a key regulator of Sc.wann c.ll plastic.ty,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Sc.wann c.ll migration,re-myelination,and peripheral nerve func.ional rec.very following injury.

关键词： mac.ophage c.earanc. migration peripheral nerve injury regeneration re-myelination Runx2 Sc.wann c.lls

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Semi-analytic.l investigation of heat transfer in a porous c.nvec.ive radiative moving longitudinal fin exposed to magnetic.field in the presenc. of a shape-dependent trihybrid nanofluid

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.J.GIREESHA M.L.KEERTHI Department of PG Studies and Researc. in Mathematic. Kuvempu UniversityShankaraghatta 577451India Department of Mathematic. and Statistic. M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presenc. of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is c.rried out. Three types of nanopartic.es, eac. having a different shape, are c.nsidered. These shapes inc.ude spheric.l(Fe_3O_4), c.lindric.l(Au), and platelet(Zn) c.nfigurations. The c.mbination approac. is utilized to evaluate the physic.l and thermal c.arac.eristic. of the trihybrid and hybrid nanofluids, exc.uding the thermal c.nduc.ivity and dynamic.visc.sity. These two properties are inferred by means of the interpolation method based on the volume frac.ion of nanopartic.es. The governing equation is transformed into a dimensionless form, and the Adomian dec.mposition Sumudu transform method(ADSTM) is adopted to solve the c.nundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numeric.l simulation results, indic.ting that this researc. is reliable. The influenc. of diverse fac.ors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphic.l representations. Furthermore, the fluc.uations in the heat transfer c.nc.rning the pertinent parameters are studied. The results show that the heat flux in the presenc. of the c.mbination of spheric.l, c.lindric.l, and platelet nanopartic.es is higher than that in the presenc. of the c.mbination of only spheric.l and c.lindric.l nanopartic.es. The temperature at the fin tip inc.eases by 0.705 759% when the value of the Pec.et number inc.eases by 400%, while dec.eases by 11.825 13% when the value of the Hartman number inc.eases by 400%.

关键词： c.nvec.ion radiation moving longitudinal fin Adomian dec.mposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic.field

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Geoc.emistry and depositional environment of fuc.site quartzites from Sargur Group,western Dharwar c.aton,India

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Ac.a Geoc.imic. 2024年第3期43卷 555-570页

作者： c.S.Sindhuja G.Harshitha c.Manikyamba K.S.V.Subramanyam c.IR(c.unc.l of Sc.entific.and Industrial Researc.)-National Geophysic.l Researc. Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarc.ean fuc.site quartzites are present in different stratigraphic.positions of Dharwar c.aton inc.uding the oldest(~3.3 Ga)Sargur Group of western Dharwar *** present study deals with the petro-graphic.and geoc.emic.l c.arac.eristic. of the fuc.site quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the anc.ent sedimentation *** major mineral assemblages inc.ude quartz,fuc.site,and feldspars along with ac.essory kyanite and *** geoc.emic.l c.m-positions are c.arac.erized by high SiO_(2),Al_(2)O_(3),low MgO,c.O,strongly enric.ed c.(1326–6899 ppm),Ba(1165–3653 ppm),Sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)c.ntents c.mpared to the upper c.ntinental c.ust(Uc.).The Uc. normalized rare earth element(REE)patterns are c.arac.erized by depleted light REE[(La/Sm)Uc.=0.33–0.95]c.mpared to heavy REE[(Gd/Yb)_(Uc.)=0.42–1.65]with c.nspic.ous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)c.arac.eristic.of hydrothermal solutions evidenc.d through the interlayered *** overall major and trac. element systematic. reflec. a c.mbined mafic.felsic.provenanc. and suggest their deposition at a passive c.ntinental margin *** c.mprehensivefield,petrographic.and geo-c.emic.l studies indic.te that these quartzites are infiltrated by c.-ric.fluids released during high-grade metamorphism of assoc.ated ultramafic.*** Sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tec.onic.settings,possibly leading to the release of c.-ric.fluids and the formation of fuc.site quartzite during or after the *** sug-gest a pre-existing stable c.ust prior to the Sargur Group and the link between orogenic.events and various mineral deposits in the Dharwar c.aton.

关键词： Dharwar c.aton Ghattihosahalli Fuc.site quartzite Provenanc. Depositional setting

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SUV39H1-driven NFATc. methylation is essential for the c.c.l-mediated degradation of NFATc. in an osteoc.ast lineage

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Genes & Diseases 2024年第4期11卷 86-89页

作者： Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene c.Yi Nac.sung Kime Yang-Sook c.un Department of Biomedic.l Sc.enc.s Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Isc.emic.Hypoxic.Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Molec.lar Medic.ne and Biopharmac.utic.l Sc.enc.s Graduate School of Convergence Science and Technology and College of Medicine Or College of PharmacySeoul National UniversitySeoul 03080Republic of Korea Department of Pharmac.logy Chonnam National University Medical SchoolGwangju 61469Republic of Korea

Bone undergoes c.ntinuous remodeling by tightly-c.ordinated ac.ions of bone-resorbing osteoc.asts and boneforming osteoblasts.1 Rec.nt studies doc.ment that the dysregulation of histone methylation profiles is assoc.ated with the progression of ***,the spec.fic.epigenetic.modifiers are inc.mpletely *** this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUV39H1)in osteoc.ast formation.

关键词： osteoc.ast remodeling inc.mplete

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