Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination

作     者：Rong Hu Xinpeng Dun Lolita Singh Matthew C.Banton Rong Hu;Xinpeng Dun;Lolita Singh;Matthew C.Banton

作者机构：School of Traditional Chinese MedicineDepartment of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Faculty of HealthUniversity of PlymouthPlymouthUK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第7期

页      面：1575-1583页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China No.82104795 (to RH) 

主　　题：macrophage clearance migration peripheral nerve injury regeneration re-myelination Runx2 Schwann cells 

摘      要：Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea ***,we analyzed Runx2expression following injury and found that it was specifically up-regulated in Schwann ***,using Schwann cell-specific Runx2 knocko ut mice,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were *** observed in Runx2 knoc kout mice include increased prolife ration of Schwann cells,impaired Schwann cell migration and axonal regrowth,reduced re-myelination of axo ns,and a block in macrophage clearance in the late stage of *** together,our findings indicate that Runx2 is a key regulator of Schwann cell plasticity,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Schwann cell migration,re-myelination,and peripheral nerve functional recovery following injury.