Non-coding RNAs in exercise immunology:A systematic review

作     者：Mona Kotewitsch Melina Heimer Boris Schmitz Frank C.Mooren Mona Kotewitsch;Melina Heimer;Boris Schmitz;Frank C.Mooren

作者机构：Department of Rehabilitation SciencesFaculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV Clinic KonigsfeldCenter for Medical RehabilitationEnnepetal 58256Germany 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2024年第13卷第3期

页      面：311-338,I0002页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 1202[管理学-工商管理] 04[教育学] 

基　　金：supported by the European Commission within the Horizon 2020 framework program(Grant No.101017424) 

主　　题：Immune system Inflammation MicroRNA ncRNA Physical exercise 

摘      要：Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflammation,and improved overall *** strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical *** combined approaches were used:(a)a systematic literature search for“ncRNA and exercise immunology,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reactome database,combined with a systematic literature search for“ncRNA and exercise.Literature searches were based on PubMed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exercise-based interventions in healthy *** duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qualitative *** studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also *** were analyzed using ordering tables that included exercise modality(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between *** criteria were defined as“validatedwith 100%of
≥3 independent studies showing identical direction of regulation,“plausible(≥80%),or“suggestive(≥70%).For resistance exercise,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** endurance exer