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Phenol contaminated municipal wastewater treatment using date palm frond biochar:Optimization using response surface methodology

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Emerging Contaminants 2023年第1期9卷 53-67页

作者： Yohanna Haile Fseha Jamal Shaheen banu Sizirici Department of Civil Infrastructure and Environmental Engineering Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates

Phenol is classified as an emerging contaminant which can be very toxic even at low concentrations and should be removed from wastewaters before reaching the *** this study date palm frond and leaf were pyrolyzed at different temperatures to identify the best adsorbent(feedstock)and pyrolysis temperature to remove phenol from aqueous *** palm frond pyrolyzed at 600℃,termed DPF600,achieved the highest phenol removal rates of 64%and adsorption capacity of 15.93 mg/*** surface methodology approach using Box-Behnken design was implemented to obtain the optimal pH(6),contact time(20 h)and dosage(0.1 g)for the maximum phenol adsorption.A predicted adsorption capacity was found as 16.62 mg/g which was in close agreement with the experimental adsorption capacity of 17.38 mg/*** and kinetic models in both linear and non-linear forms indicated that Freundlich model(R^(2)=0.99,χ^(2)=0.02,RMSE=1.09)and pseudo-second order model(R^(2)=0.99,χ^(2)=0.85,RMSE=5.41)fit best the obtained experimental *** calculations affirmed that the adsorption of phenol onto DPF600 biochar was endothermic and *** point of zero charge was found to be at 6.5 for DPF600 *** electron microscopy coupled with energy dispersive X-ray,Fourier transform infrared spectroscopy and X-ray diffraction confirmed adsorption of phenol onto DPF600 *** of DPF600 biochar to remove phenol from synthetic primary and secondary treated wastewater samples achieved 60 and 85%removal rates and 241 mg/g and 22.28 mg/g adsorption capacities,*** studies showed promising adsorption capacities indicating the efficacy of DPF600 for the removal of phenol from wastewater.

关键词： Phenol contaminated wastewater Date palm frond Biochar Box-behnken design Response surface methodology Adsorption capacity

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Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence

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World Journal of Clinical Cases 2022年第31期10卷 11226-11239页

作者： Niyazi Emre Kurşunoğlu banu Pinar Sarer Yurekli School of Medicine Ege Universityİzmir 35100Turkey Department of Endocrinology Ege University School of Medicineİzmir 35100Turkey

Obesity is becoming an inevitable pandemic all over the *** World Obesity Federation predicts in the 2022 World Obesity Atlas that one billion people worldwide,including 1 in 5 women and 1 in 7 men,will be living with obesity by ***,the prevalence of diabetes is increasing worldwide,and diabetes is becoming more of a public health *** insulin resistance due to obesity and deficiency in insulin secretion are the two main causes of type 2 diabetes mellitus(T2DM).An exogenous chemical or mixture of chemicals that interferes with any aspect of hormone action was defined as endocrine-disrupting chemicals(EDCs).Bisphenol A(BPA),the first known EDC,was synthesized and was considered to be *** production of BPA has increased progressively from 5 to 8 million tons(MT)between 2010 and ***,researchers estimated that the production should reach 10.2 MT by *** human population is exposed to EDCs in daily life in such forms as pesticides/herbicides,industrial and household products,plastics,detergents,and personal care *** term obesogen was used for chemicals that promote weight gain and obesity by increasing the number of adipocytes and fat storage in existing adipocytes,changing the energy balance,and finally regulating appetite and *** the obesogenic effect,EDCs can cause T2DM through alteration inßcell function and morphology and insulin *** this review,we provide clinical and mechanistic evidence regarding EDCs as obesogen and ***,those studies are not enough methodologically to indicate *** this respect,randomized clinical trials are needed to investigate the association between obesogen,diabetogen and the related metabolic clinical picture.

关键词： Endocrine disruptors Adipogenesis Obesity Diabetes mellitus

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Changes in endothelial cell density following penetrating keratoplasty and deep anterior lamellar keratoplasty

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International Journal of Ophthalmology(English edition) 2011年第6期4卷 644-647页

作者： banu Torun Acar Ece Turan Vural Suphi Acar Ophthalmology Clinic Haydarpasa Numune Education and Research Hospital

· AIM: To compare the corneal endothelial cell density (ECD) of clear grafts after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK). · METHODS: The study included 44 and 54 patients treated with PK and DALK, respectively, between March 2006 and April 2010. Corneal ECD was examined using specular microscopy at postoperative 1, 3, 6, 12, and 18 months, and the values were compared. · RESULTS: Corneal ECD reduction in the PK group was 7.4%, 15.2%, 23.5%, and 28.9% at 3, 6, 12 and 18 months respectively after surgery, compared with 4.2 % in the first month (P 0.05). · CONCLUSION: Compared with DALK,PK significantly reduced ECD of the clear grafts. These results suggest that survival of endothelial cells in grafts is better after DALK than after PK. ·

关键词： lamellar keratoplasty penetrating keratoplasty endothelial cell density specular microscopy

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The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders

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Neural Regeneration Research 2022年第6期17卷 1165-1171页

作者： Rafhanah banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore LSI Neurobiology Programme National University of SingaporeSingaporeSingapore Institute for Health Innovation and Technology National University of SingaporeSingaporeSingapore Healthy Longevity Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function *** circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain *** converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological *** this notion,efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation,maturation,synaptogenesis and synaptic *** and elongation protein zeta-1,a Kinesin-1 adapter,has emerged as a key central player involved in many of these *** and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse ***,it acts downstream of guidance cue pathways to regulate axo-dendritic ***,perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous *** and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental ***,altered phosphorylation of the protein contributes to neurodegenerative ***,these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.

关键词： fasciculation and elongation protein zeta-1 neurological disorder neuronal development neuronal differentiation neuronal networks synapse formation synaptic function

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Comparison of visual acuity, refractive results and complications of femtosecond laser with mechanical microkeratome in LASIK

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 350-355页

作者： Cemile banu Cosar Tansu Gonen Murat Moray Asim Bozkurt Sener Department of Ophthalmology Acibadem University Department of Ophthalmology Namlk Kemal University Eye Clinic Acibadem Bursa Hospital Eye Clinic Acibadem Maslak Hospital

AIM: To compare the outcomes of laser in situ keratomileusis (LASIK) performed with a femtosecond laser (Femtec, Technolas Perfect Vision GmbH, Germany) versus a mechanical microkeratome (Hansatome, Bausch and Lomb, USA) for the correction of myopia and astigmatism. ·METHODS: In this retrospective study, patients who had undergone LASIK using the 80 -kHz Femtec femtosecond laser were compared to age- and refraction- matched patients in whom the Hansatome microkeratome was used. Refractive and visual results 1 month and 3 months postoperatively, and complication rates were compared between the two groups. ·RESULTS: A total of 280 eyes were analyzed (140 in each group). At 3 months postoperatively in the Femtec vs Hansatome group, spherical equivalent refraction was within ±1.00D of emmetropia in 140 vs 138 eyes (P = 0.498), the cylinder was within ±0.50D in 137 vs 139 eyes (P =0.622), and the UDVA was 20/20 or better in 136 vs 137 eyes (P =0.724), respectively. There was no statistically significant difference in the complication rates between the two groups (P =0.099). ·CONCLUSION: LASIK performed both with Femtec femtosecond laser and Hansatome microkeratome achieved satisfactory refractive and visual results at 3 months postoperatively, without significant differences in efficacy, safety, and complication rates between the two procedures.

关键词： laser in situ keratomileusis femtosecond laser Femtec microkeratome Hansatome

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FUNCTIONAL NEAR-INFRARED SPECTROSCOPY-BASED ASSESSMENT OF ATTENTION IMPAIRMENTS AFTER TRAUMATIC BRAIN INJURY

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 251-260页

作者： ANNA C.MERZAGORA MARIA T.SCHULTHEIS banu ONARAL MELTEM IZZETOGLU School of Biomedical Engineering Science and Health Systems Drexel University PhiladelphiaPAUSA Department of Psychology Drexel University PhiladelphiaPAUSA

A frequent consequence of traumatic brain injury(TBI)is cognitive impairment,which results in significant disruption of an individual's everyday *** date,most clinical rehabilitation interventions still rely on behavioral observation,with little or no quantitative information about physiological changes produced at the brain *** brain imaging has been extensively used in the study of cognitive impairments following ***,its applications to rehabilitation have been *** is due in part to the expensive or invasive nature of these *** objective of this study is to apply functional near-infrared spectroscopy(fNIR)to the assessment of attention impairments following *** provides a localized measure of prefrontal hemodynamic activation,which is susceptible to TBI,and it does so in a noninvasive,affordable and wearable way,thus partially overcoming the limitations of other *** included 5 TBI subjects and 11 healthy *** activation measurements were collected during a target categorization *** differences were found in the hemodynamic response between healthy and TBI *** particular,the elicited responses exhibited reduced amplitude in the TBI ***,the results providefirst evidence of the ability of fNIR to reveal differences between TBI and healthy subjects in an attention *** is therefore a promising neuroimaging technique in thefield of *** use of fNIR in neurorehabilitation applications would benefit from its noninvasiveness and cost-effectiveness and the neurophysiological information obtained through the evaluation of the hemodynamic activation could provide invaluable information to guide the choice of intervention.

关键词： fNIR attention traumatic brain injury NIRS TBI

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p21 and p27 immunoexpression in gastric well differentiated endocrine tumors(ECL-cell carcinoids)

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World Journal of Gastroenterology 2006年第39期12卷 6280-6284页

作者： Basak Doganavsargil banu Sarsik Fatma Secil Kirdok Ahmet Musoglu Muge Tuncyurek Department of Pathology Ege University Faculty of Medicine Izmir Turkey Department of Gastroenterology Ege University Faculty of Medicine Izmir Turkey

AIM： To investigate the expression of cyclin-dependent kinase inhibitors p21 and p27 in gastric well differentiated endocrine tumors （GWDET）（ECLocell carcinoids）.METHODS： The expressions of p21 and p27 were examined immunhistochemically in endoscopic biopsy specimens from 16 patients matching the diagnostic criteria of GWDET. Percentage of positive nuclear staining either weak or strong was noted. The association of immunoexpressions with age, gender, tumor localization, multifocality and accompanying chronic atrophic gastritis, neuroendocrine cell hyperplasia （NEH）, neuroendocrine dysplasia （NED）, intestinal metaplasia （IM）, Ki-67 proliferation index and clinical outcome were also ***： All cases expressed p27 with a mean expression score of 43.6%, while 31.3% of the cases showed any p21 expression, p21 and p27 immunoexpressions were significantly correlated with each other （P 〈 0.01）, and the p21-expressing group had higher p27 expression scores （68% vs 22%）. p21 and p27 expressions were lower in women, in non-atrophic mucosa and cases whose tumors were located somewhere other than fundus without submucosal extension. On contrary, p21 and p27 expressions were higher in males and the patients with submucosal extension and atrophic gastritis. Cases presenting lower p27 scores had solitary tumors showing neither NEH-NED nor IM. Despite, cases with lower p21 expression presented multifocal tumors accompanied by NEH-NED. However, no correlation of p21 and p27 expressions was found with age and Ki-67 ***： p27 is widely expressed in GWDETs, while p21 expression is sparse and observed in two thirds of the cases. Loss of p21 and p27 expressions may be correlated with different carcinoid tumor subtypes; however,more studies are needed to assess the role of these prospective markers in gastrointestinal endocrine tumors.

关键词： p21^waf1 p27^kip1 Cyclin-dependent kinase inhibitors Gastrointestinal carcinoids Well differentiated endocrine tumors Stomach

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A case of solid pseudopapillary tumor of the pancreas

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World Journal of Gastroenterology 2006年第38期12卷 6239-6243页

作者： Ozan Karatag Gulden Yenice Huseyin Ozkurt Muzaffer Basak Can Basaran banu Yilmaz Department of Radiology Sisli Etfal Education and Research Hospital Istanbul Turkey Department of Surgery Sisli Etfal Education and Research Hospital Istanbul Turkey Department of Pathology Sisli Etfal Education and Research Hospital Istanbul Turkey

We present ultrasound, computed tomography and magnetic resonance imaging findings in a case with pancreatic solid pseudopapillary tumor and their correlations with histopathology. Ultrasound revealed a hypoechogenic mass, and computed tomography revealed a hypodense mass at the pancreatic head minimally enhanced after intravenous contrast agent administration. Magnetic resonance imaging showed a hypointense mass on unenhanced Tl-weighted images including a hyperintense focus representing the hemorrhage. The lesion was hyperintense on T2- weighted images. On the postcontrast images the lesion showed peripheral thin contrast enhancement in arterial phase and enhanced slightly diffusely in venous and equilibrium phases. The patient underwent elective resection of the mass and pancreatoduodenectomy with jejunostomy tube placement. A final diagnosis of solid pseudopapillary tumor was made histoPathologically. Solid pseudopapillary tumor is a rare pancreatic tumor. It is important to make the diagnosis preoperatively because with an adequate surgical resection the prognosis is good. A multimodalitary approach, especially magnetic resonance imaging can suggest the diagnosis without the need for biopsy.

关键词： Pancreas Solid pseudopapillary tumor Magnetic resonance imaging Computed tomography Ultrasound

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Ameliorating effect of Semecarpus anacardium *** milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 956-961页

作者： Haseena banu Hedayathullah Khan Kaladevi Siddhi Vinayagam Shanthi Palanivelu Sachdanandam Panchanadham Department of Medical Biochemistry DR.A.L.M.P-G.I.B.M.S.University of MadrasTaramani CampusChennai-600113India

Objective:To explore the protective effect of the drug Semecarpus anacardium(***) on altered glucose metabolism in diabetic ***:Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ)(35 mg/kg b.w.).Seven days after STZ induction,diabetic rats received nut milk extract of *** *** milk extract orally at a dosage of 200 mg/kg daily for 4 *** effect of nut milk extract of *** on blood glucose,plasma insulin,glucose metabolising enzymes and GSK were ***:Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA-βand decrease in HOMA -*** drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic *** drug also effectively ameliorated the alterations in GSK-3 mRNA ***:Overall,the present study demonstrates the possible mechanism of glucose regulation of *** suggestive of its therapeutic potential for the management of diabetes mellitus.

关键词： Semecarpus anacardium Streptozotocin Carbohydrate metabolism Insulin signalling

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Subthreshold micropulse laser versus intravitreal anti-VEGF for diabetic macular edema patients with relatively better visual acuity

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1606-1611页

作者： Sezen Akkaya banu Acιkalιn Yusuf Emre Dogan Fatih Coban Departmant of Ophthalmology Saglιk Bilimleri UniversityFSM Training and Research Hospitallstanbul 34752Turkey

AIM:To compare the effects of yellow(577 nm)subthreshold micropulse laser(SML)and intravitreal(IV)anti-vascular endothelial growth factor(VEGF)treatment in patients with diabetic macular edema(DME)with relatively better visual acuity[best corrected visual acuity(BCVA)≤0.15 log MAR].METHODS:The medical records of 76 eyes of 47 patients underwent IV(0.5 mg)anti-VEGF injection or SML for the DME with relatively better BCVA were *** IV group received three consecutive monthly IV anti-VEGF injections,then were retreated as *** laser treatment group was treated at baseline and 3 mo,and then retreated at 6 and 9 mo if *** participants were followed up for one *** mean BCVA and mean central macular thickness(CMT)values changes over the follow-up were ***:Twenty-four and 23 patients were assigned to the SML and IV subgroups,*** mean number of treatments was 3.64±0.76 in SML group and 5.85±1.38 in IV group(P<0.05).The subgroups were similar with regard to the mean BCVA score at baseline and at the 1st and 3rd months,but the score of SML group was better than that of IV group at the 6th,9th,and 12th months(P<0.05).The decrease in the mean CMT values from baseline values was higher in SML group at the 6th,9th,and 12th months(P<0.05).CONCLUSION:Yellow SML treatment is superior to IV anti-VEGF injection in DME patients with relatively better BCVA for increasing visual acuity and decreasing CMT at 6,9,and 12 *** can be a good alternative first-line therapy for DME with BCVA≤0.15 log MAR.

关键词： diabetic macular edema subthreshold micropulse laser anti-VEGF injection

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