Ameliorating effect of Semecarpus anacardium *** milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats
Ameliorating effect of Semecarpus anacardium *** milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats作者机构：Department of Medical BiochemistryDR.A.L.M.P-G.I.B.M.S.University of MadrasTaramani CampusChennai-600113India
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2012年第5卷第12期
页 面：956-961页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：financial assistance offered in the form of UGC RFSMS
主 题：Semecarpus anacardium Streptozotocin Carbohydrate metabolism Insulin signalling
摘 要：Objective:To explore the protective effect of the drug Semecarpus anacardium(***) on altered glucose metabolism in diabetic ***:Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ)(35 mg/kg b.w.).Seven days after STZ induction,diabetic rats received nut milk extract of *** *** milk extract orally at a dosage of 200 mg/kg daily for 4 *** effect of nut milk extract of *** on blood glucose,plasma insulin,glucose metabolising enzymes and GSK were ***:Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA-βand decrease in HOMA -*** drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic *** drug also effectively ameliorated the alterations in GSK-3 mRNA ***:Overall,the present study demonstrates the possible mechanism of glucose regulation of *** suggestive of its therapeutic potential for the management of diabetes mellitus.
维普期刊数据库