The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders

作     者：Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua Rafhanah Banu Bte Abdul Razar;Yinghua Qu;Saravanan Gunaseelan;John Jia En Chua

作者机构：Department of PhysiologyYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore LSI Neurobiology ProgrammeNational University of SingaporeSingaporeSingapore Institute for Health Innovation and TechnologyNational University of SingaporeSingaporeSingapore Healthy Longevity Translational Research ProgramYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Institute of Molecular and Cell BiologyAgency for ScienceTechnology and Research(A*STAR)SingaporeSingapore 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第6期

页      面：1165-1171页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：the Singapore Ministry of Education(T1-2015 Apr-03) the National University of Singapore Institute for Health Innovation and Technology to JJEC 

主　　题：fasciculation and elongation protein zeta-1 neurological disorder neuronal development neuronal differentiation neuronal networks synapse formation synaptic function 

摘      要：The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function *** circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain *** converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological *** this notion,efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation,maturation,synaptogenesis and synaptic *** and elongation protein zeta-1,a Kinesin-1 adapter,has emerged as a key central player involved in many of these *** and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse ***,it acts downstream of guidance cue pathways to regulate axo-dendritic ***,perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous *** and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental ***,altered phosphorylation of the protein contributes to neurodegenerative ***,these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.