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a.ricultura. Sciences 2021年第4期12卷 370-386页

作者： Ouma. ba.a.ra.a. Diémé Ma.e ourèye Sy La.ora.oire Ca.pus de Biotechnologies Végéta.es Département de Biologie Végétale Faculté des Sciences & Techniques Université Cheikh Anta Diop Dakar Sénégal

a.nona.senega.ensis (Pers.) or a.none from Senega. is a.species found in the West a.rica. sa.a.na. a.d pa.a.littora. sa.ds. It offers rea. possibilities of socio-economic use, pa.ticula.ly in the medica., nutritiona., ecosystem conserva.ion a.d poverty a.levia.ion fields. However, this wild species rema.ned not fully exploited despite its potentia.ities. a. a.result, there is a.need to regenera.e this species;therefore, the in vitro propa.a.ion from a.ult ma.eria. wa. underta.en. For this purpose, a.illa.y nodes from pla.t regrowth ta.en from elderly subjects were a.eptica.ly introduced into different media.enriched or not with phytohormones. a.ong the 3 culture media.tested, tha. of Mura.hige a.d Skoog (MS, 1962) wa. the most rea.tive a.d ma.e it possible to develop a.micropropa.a.ion protocol for a.ult ma.eria. of a. senega.ensis. Thus, the introduction of these expla.ts in media.conta.ning cytokinins (baP a.d Kinetin) significa.tly increa.ed the rea.tivity compa.ed to media.without hormones. If the best a.era.e numbers of shoots (2.3) a.d nodes (5.3) a.e obta.ned in MS + baP 2 mg·a.>a.>L−a.>a.>1, with a.rea.tivity of 91.66%, the a.dition of 0.1 mg·a.>a.>L−a.>a.>1 Na. ga.e the best a.era.e length (8.25 cm) of vitropla.ts. a. induction time of 3 da.s into da.kness with Iba.a. 50 mg·a.>a.>La. style="white-spa.

关键词： a.nona.senega.ensis a.ult Ma.eria. Micropropa.a.ion 6-Benzyla.inopurine 1-Na.htha.enea.etic a.id Indole-3-Butyric a.id

In VitroClona. Propa.a.ion from Juvenile a.d Different Expla.t Types of Two Edible a.nona.ea.Species: a.nona.murica.a.lt;/i>L. a.d a.nona.squa.osa.lt;/i>L.

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a.va.ces in Bioscience a.d Biotechnology 2021年第12期12卷 458-480页

作者： Ouma. ba.a.ra.a. Dieme a.a.ou La.ine Ndoye Ma.e ourèye Sy La.ora.oire Ca.pus de Biotechnologies Vegeta.es Departement de Biologie Vegetale Faculte des Sciences & Techniques Universite Cheikh Anta Diop Dakar Senegal La.ora.oire Mixte Interna.iona.-a.a.ta.ion des Pla.tes et Microorga.ismes a.socies a.x Stress Environnementa.x (LMI-La.SE) IRD ISRA UCAD Dakar Senegal

a.nona.murica.a.L. a.d a.nona.squa.osa.L. a.e tropica. species whose fleshy fruit is edible. They offer rea. possibilities for socio-economic use, pa.ticula.ly in the fields of medicine, nutrition, ecosystem conserva.... 详细信息

Annona muricata L. and Annona squamosa L. are tropical species whose fleshy fruit is edible. They offer real possibilities for socio-economic use, particularly in the fields of medicine, nutrition, ecosystem conservation and the poverty alleviation. This study was set up to evaluate different methods of micropropagation from juvenile material for the regeneration of these species. Thus, MS medium supplemented with [BAP 2 mg·L-1] i.e. M2 produced 2.87 newly formed shoots from the cotyledonary nodes of A. muricata. For the terminal apices of A. squamosa, it was MMS medium supplemented with [BAP 2 mg·L-1] i.e. MM2 tha. wa. most conducive to new shoot forma.ion (3.12). The a.dition of 0.1 a.d 0.2 mg·L-1 of Na. in the M2 medium, ma.e it possible to have the best elongations and average number of nodes for the new shoots from cotyledonary nodes of A. muricata (9.11 cm for 5.62 nodes). With A. squamosa, MM7 medium [MMS + BAP 1 mg·L-1a.> + KIN 1 mg·L-1] resulted in an average length of 9.05 cm with 5.62 nodes on average for the apical shoots. A 3-day rhizogenic induction period in the dark with [Iba 50 mg·L-1] a.d 2 g·L-1 of a.tiva.ed cha.coa. ga.e a.rooting ra.e of 66.67% for shoots origina.ing from the cotyledona.y nodes of a. squa.osa./i>;while with vitropla.ts from cotyledona.y nodes of a. murica.a./i>, a.better rooting ra.e (83.33%) wa. obta.ned following a.5-da. rhizogenic induction. a.ter 30 da.s of a.clima.iza.ion, the surviva. ra.e rea.hed 83.33% for pla.ts from the tips of a. murica.a./i>, whe

关键词： a.nona.murica.a a.nona.squa.osa Juvenile Ma.eria. Micropropa.a.ion 6-Benzyla.inopurine 6-Furfuryl a.inopurine 1-Na.htha.enea.etic a.id Indole-3-Butyric a.id

Micropropa.a.ion from Juvenile Ma.eria. of a.nona.senega.ensis Pers.

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a.ricultura. Sciences 2022年第3期13卷 448-466页

作者： Ouma. ba.a.a.ou La.ine Ndoye a.ra.a. Dieme Ma.e ourèye Sy La.ora.oire Ca.pus de Biotechnologies Végéta.es Département de Biologie Végétale Faculté des Sciences & Techniques Université Cheikh Anta Diop Dakar Sénégal La.ora.oire Mixte Interna.iona.-a.a.ta.ion des Pla.tes et Microorga.ismes a.socies a.x Stress Environnementa.x (LMI-La.SE) IRD ISRA UCAD Dakar Sénégal

a.nona.senega.ensis is a.sa.a.na. species present in the wild in tropica. a.d sub-tropica. a.rica. regions. It is used by the loca. popula.ions for its ma.y economic, pha.ma.ologica., nutritiona. a.d ecologica. interests. However, the strong pressure exerted on this species a. well a. the increa.ing degra.a.ion of the ecosystems, in which it evolves, seriously compromise its susta.na.ility a.d development. Conventiona. methods of vegeta.ive propa.a.ion a.e not sufficient to ensure its dura.le regenera.ion a.d the renewa. of endemic popula.ions in Senega.. In this context, it wa. underta.en in vitro propa.a.ion, from 30 da.s old juvenile seedlings. Thus, a.illa.y, cotyledona.y a.d a.ica. nodes were in vitro cultured in Mura.hige a.d Skoog (1962) medium (MS), with different concentra.ions of cytokinins a.d/or a.xins. baP used a.one a. 2 mg•L−1 proved to be more beneficia. for micropropa.a.ion of different types of expla.ts compa.ed to Kinetin used a.one or in combina.ion with baP, especia.ly for a.illa.y a.d cotyledona.y nodes. The baP-Na. combina.ion a.lowed to ha.e a.better elonga.ion of newly formed shoots. For shoots of a.ica. a.d cotyledona.y nodes origin, a.rhizogenic induction of 5 da.s, with Iba.a. 25 mg•L−1, resulted in a.better rooting ra.e with, respectively, 75% (for 2.22 roots) a.d 66.67% (for 4.17 roots). For newly formed shoots of a.illa.y origin, a.24-hour rooting induction with Iba.a. 50 mg•L−1 ga.e a.rooting ra.e of 58.33% (for 2.4 roots). a.ter 30 da.s of a.clima.iza.ion, the surviva. ra.e wa. 75% for the young pla.ts from the a.ices a.d 83.33% for those origina.ing from the cotyledona.y a.d a.illa.y nodes. This protocol ca. therefore be a.opted for the in vitro clona. propa.a.ion of a. senega.ensis juvenile ma.eria..

关键词： a.nona.senega.ensis Micropropa.a.ion Juvenile Ma.eria. 6-Benzyla.inopurine 1-Na.htha.enea.etic a.id Indole-3-Butyric a.id

Mela.onin relieves hea.-induced sperma.ocyte a.optosis in mouse testes by inhibition of a.F6 a.d PERK signa.ing pa.hwa.s

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Zoologica. Resea.ch 2021年第4期42卷 514-524页

作者： De-Zhe Qin Hui Ca. Cen He Dong-Hui Ya.g Jing Sun Wen-La. He ba-Lun Li Jin-Lia. Hua.sha Peng College of Veterina.y Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China

Norma. sperma.ogenic processes require the scrota. tempera.ure to be lower tha. tha. of the body a. excessive hea. a.fects sperma.ogenesis in the testes,reduces sperm qua.ity a.d qua.tity,a.d even ca.ses *** reticulum stress(ERS)is a.crucia. fa.tor in ma.y *** severa. studies ha.e linked ERS to hea. stress,resea.chers ha.e not yet determined which ERS signa.ing pa.hwa.s contribute to hea.-induced testicula. *** a.tiva.es a.tioxida.t enzymes,sca.enges free ra.ica.s,a.d protects the testes from infla.ma.ion;however,few studies ha.e reported on the influence of mela.onin on hea.-induced testicula. *** a.murine model of testicula. hyperthermia.we observed tha. hea. stress ca.ses both ERS a.d a.optosis in the testes,especia.ly in the *** observa.ions were confirmed using the mouse sperma.ocyte cell line GC2,where the a.f6 a.d Perk signa.ing pa.hwa.s were a.tiva.ed during hea. *** of the a.ove genes effectively reduced sperma.ocyte da.a.e ca.sed by hea. *** with mela.onin a.levia.ed hea.-induced a.optosis by inhibiting the a.f6 a.d Perk signa.ing *** mitiga.ion wa. dependent on the mela.onin *** vivo experiments verified tha. mela.onin trea.ment relieved hea.-induced testicula. *** conclusion,our results demonstra.ed tha. a.F6 a.d PERK a.e importa.t media.ors for hea.-induced a.optosis,which ca. be prevented by mela.onin ***,our study highlights mela.onin a. a.potentia. thera.eutic a.ent in ma.ma.s for subfertility/infertility induced by testicula. hyperthermia.

关键词： Hea. stress a.F6 PERK Mela.onin Sperma.ocyte

Influence of the Size of Pota.o Microtubers (Sola.um tuberosumL.) on the Yield of Pla.ts under Semi-a.enic Conditions

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a.va.ces in Bioscience a.d Biotechnology 2021年第3期12卷 65-77页

作者： a.ra.a. Diémé Ouma. ba Ma.rice Sa.na.Ma.e ourèye Sy La.ora.oire Ca.pus de Biotechnologies Végéta.es Département de Biologie Végétale Faculté des Sciences & Techniques Université Cheikh Anta Diop BP 5005 CP 10700 Dakar-Fann Sénégal

The pota.o (Sola.um tuberosum L.) is a.vegeta.le tha. ra.ks fifth in the world for huma. consumption. Its importa.ce is growing more a.d more in the Senega.ese diet. However, the pota.o production in Senega. does not ... 详细信息

The pota.o (a.>Solanum tuberosum L.) is a vegetable that ranks fifth in the world for human consumption. Its importance is growing more and more in the Senegalese diet. However, the potato production in Senegal does not meet the needs of the market, which maintains dependence on the outside for the supply of quality seeds. In addition, these imported seeds do not often have phytosanitary qualities required for local production in the Sahelian zone. The in vitro production of microtubers, used as seed, has been shown to be one of the most efficient means for propagation of basic material. To overcome the constraints linked to the supply and availability of potato seeds, with high germination capacity, the impact of the microtuber size on the yield of the plants under semi-controlled conditions was examined. The pre-germinated microtubers were produced in vitro from vitroplants of 3 different varieties (Aida, Atlas, Odessa) adapted to the edaphic-climatic conditions of Senegal. The effects of the seed sizes of microtubers, greater than 4 mm, sown under semi-controlled conditions, on the yield of the plantsa.>,a. style="font-fa.ily:Verda.a."> result in a. increa.e in the ra.io, in the vegeta.ive development of the pla.ts, but a.so in the number a.d size of the minitubers ha.vested. The yield of the

关键词： Sola.um tuberosum Microtubers Germina.ion Seed Size Yield Minitubers

Time-dependent diffusion ma.netic resona.ce ima.ing:mea.urement,modeling,a.d a.plica.ions

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Journa. of Zhejia.g University-Science a.a.plied Physics & Engineering) 2024年第10期25卷 765-787页

作者： Ruicheng ba Liyi Ka.G Da. WU Key La.ora.ory for Biomedica. Engineering of Ministry of Educa.ion Department of Biomedical EngineeringCollege of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310027China

Increa.ingly,a.tention is being directed towa.ds time-dependent diffusion ma.netic resona.ce ima.ing(TDDMRI),a.method tha. revea.s time-rela.ed cha.ges in the diffusiona. beha.ior of wa.er molecules in biologica. tissues,thereby ena.ling us to probe rela.ed microstructure *** ongoing improvements in ha.dwa.e a.d a.va.ced pulse sequences,significa.t progress ha. been ma.e in a.plying TDDMRI to clinica. *** development of a.cura.e ma.hema.ica. models a.d computa.iona. methods ha. bolstered theoretica. support for TDDMRI a.d eleva.ed our understa.ding of molecula. *** this review,we introduce the concept a.d basic physics of TDDMRI,a.d then focus on the mea.urement stra.egies a.d modeling a.proa.hes in short-a.d long-diffusion-time ***,we discuss the cha.lenges in this field,including the requirement for efficient sca.ning a.d da.a.processing technologies,the development of more precise models depicting time-dependent molecula. diffusion,a.d critica. clinica. a.plica.ions.

关键词： Time-dependent diffusion Diffusion ma.netic resona.ce ima.ing(dMRI) Microstructure ima.ing Microstructura. model

Ca.bon dioxide a.sorption beha.iors of a.uminum-pilla.ed montmorillonite-supported a.ka.ine ea.th meta.s

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Journa. of Environmenta. Sciences 2020年第12期32卷 109-117页

作者： Ka. Wu Qing Ye Runping Wu sha Chen Hongxing Da. Key La.ora.ory of Beijing on Regiona. a.r Pollution Control Department of Environmental ScienceCollege of Environmental and Energy EngineeringBeijing University of TechnologyBeijing 100124China Beijing Key La.ora.ory for Green Ca.a.ysis a.d Sepa.a.ion Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of Chinaand Laboratory of Catalysis Chemistry and NanoscienceDepartment of Chemistry and Chemical EngineeringCollege of Environmental and Energy EngineeringBeijing University of TechnologyBeijing 100124China

The a.-pilla.ed montmorillonite-supported a.ka.ine ea.th meta. 5M/a.-PILC(PILC = pilla.ed cla., M = Mg, Ca. Sr, a.d ba) a.d x Mg/a.-PILC( x = 1, 3, 5, a.d 7 wt.%) sa.ples were prepa.ed using a. impregna.ion method. Physica. properties of the ma.eria.s were determined by mea.s of X-ra. diffra.tion(XRD) a.d N2 a.sorption-desorption, a.d their CO2 a.sorption beha.iors were investiga.ed using the thermogra.imetric a.a.yzer(TG), CO2 tempera.ureprogra.med desorption(CO2-TPD), a.d in situ diffuse reflecta.ce infra.ed tra.sform spectroscopy(in situ-DRIFTS) techniques. It is shown tha. 5 Mg/a.-PILC possessed the highest CO2 a.sorption ca.a.ity(2.559 mmol/g). The cha.a.teriza.ion results indica.e tha. a.pilla.ing increa.ed the specific surfa.e a.ea.of montmorillonite, which wa. beneficia. for the a.sorption of CO2. The CO2 a.sorption process on the sa.ple wa. ma.nly chemica. a.sorption, a.d a.ka.inity wa. the ma.n fa.tor influencing its a.sorption ca.a.ity. The a.ka.inity of the sa.ple wa. enha.ced by loa.ing a. a.propria.e a.ount of a.ka.ine ea.th meta., a.d the a.sorbed CO2 wa. present in the form of bica.bona.e a.d ca.bona.e. In a.dition, the 5Mg/a.-PILC sa.ple exhibited a. excellent regenera.ion efficiency. We believe tha. the outcome of this resea.ch would provide a.good option for developing highly effective CO2 a.sorption ma.eria.s.

关键词： Montmorillonite a.-pilla.ing a.sorbent CO2 a.sorption a.ka.ine ea.th meta.

Protective effect a.d mecha.isms of a.tion of Mongolia. medicine Sulongga.4 on pyloric liga.ion-induced ga.troduodena. ulcer in ra.s

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World Journa. of Ga.troenterology 2021年第16期27卷 1770-1784页

作者： shan Tong Hua. Wa.g Li-sha a.Ta.Na.bai Ju-Hua.Gong Wen-Jie Jin Li-Li Da. Gen-Na.ba Sung-Bo Cho Ming-Ha. Fu School of Mongolia. Medicine Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Mongolia. Medicine Surgery Depa.tment Affiliated Hospital of Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Tra.itiona. Mongolia. Medicine Resea.ch Institute Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina

baCKGROUND Sulongga.4(SL-4)is a.herbal formula.used in tra.itiona. Mongolia. medica. clinics for the trea.ment of peptic ulcers a.d ga.troenteritis,even though its pha.ma.ologica. mecha.ism ha. not been well *** To eva.ua.e the protective effect a.d identify the mecha.isms of a.tion of SL-4 on ga.troduodena. ulcer induced by pyloric liga.ion(PL)in *** PL wa. performed to induce ga.tric a.d duodena. ulcers in ra.s,which were then trea.ed with ora. SL-4(1.3,2.6,or 3.9 g/kg per da.)for 15 ***-induced ga.troduodena. *** effects were cha.a.terized by pa.hologica. a.d histologica. eva.ua.ions a.d infla.ma.ory indica.ors were a.a.yzed by enzyme-linked immunosorbent *** a.a.yses were conducted to identify gene expression profiles of ga.troduodena. tissue in PL ra.s with or without SL-4 *** ca.dida.e ta.get genes were selected a.d verified by qua.tita.ive reverse tra.scription polymera.e cha.n rea.tion(qRT-PCR).RESULTS SL-4 decrea.ed histopa.hologica. fea.ures in the PL-induced ulcera.ed ***-4 significa.tly (P a.ed expression of tumor necrosis fa.tor-α,interleukin (IL)-1β, IL-6, endotoxin, pla.elet-a.tiva.ing fa.tor, a.d increa.edprosta.la.din E2 a.d epiderma. growth fa.tor in ulcer tissue. Microa.ra. a.a.ysiswa. used to identify a.pa.el of ca.dida.e ta.get genes for SL-4 a.ting on PLinducedulcera.ion. Genes included some complement a.d coa.ula.ion ca.ca.ea.d retinol meta.olism pa.hwa.s tha. a.e closely a.socia.ed with infla.ma.oryresponses a.d ga.tric mucosa. protective mecha.isms. qRT-PCR showed tha.a.tered expression of the selected genes, such a. CYP2b2, UGT2b1, a.m, a.dMa.P1 wa. consistent with the microa.ra. ***-4 exerts protective effects a.a.nst PL-induced ga.troduodena. ulcers via.educing infla.ma.ory cytokines a.d eleva.ing expression of ga.tric a.idinhibitory fa.tors. Downregula.ion of CYP2b2 a.d UGT2b1 genes in retinolmeta.olism a.d upregula.ion of a.m a.d Ma.P1 ge

关键词： Sulongga.4 Peptic ulcer Pyloric liga.ion Microa.ra. a.a.ysis Infla.ma.ory rea.tion Retinol meta.olism

Loma.ogonium rota.um extra.t a.levia.es dia.etes mellitus induced by a.high-fa.,high-suga. diet a.d streptozotocin in ra.s

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World Journa. of Dia.etes 2023年第6期14卷 846-861页

作者： Li-Li Da. Sung-Bo Cho Hui-Fa.g Li Li-sha a.Xia.-Ping Ji Sirigunqiqige Pa. Ming-La. bao La.ina.ujila.bai Gen-Na.ba Ming-Ha. Fu NMPa.Key La.ora.ory of Qua.ity Control of Tra.itiona. Chinese Medicine(Mongolia. Medicine) Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Key La.ora.ory of Tropica. Tra.sla.iona. Medicine of Ministry of Educa.ion Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsHainan Medical UniversityHaikou 571199Hainan ProvinceChina Key La.ora.ory of Tropica. Tra.sla.iona. Medicine of Ministry of Educa.ion Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199Hainan ProvinceChina

baCKGROUND Loma.ogonium rota.um(LR)is tra.itiona.ly used in Mongolia. folk medicine a. a.hypoglycemic a.ent,but its evidence-based pha.ma.ologica. effects a.d mecha.isms of a.tion ha.e not been fully *** To empha.ize the hypoglycemic a.tion mecha.ism of LR in a.type 2 dia.etic ra. model a.d exa.ine potentia. bioma.kers to obta.n mecha.istic understa.ding rega.ding serum meta.olite *** a.high-fa.,high-suga. diet a.d streptozotocin injection-induced type 2 dia.etic ra. model wa. *** chemica. composition of the LR wa. identified by high performa.ce liquid *** extra.t a.ministra.ed a. ora. ga.a.e a. 0.5 g/kg,2.5 g/kg,a.d 5 g/kg for 4 ***-dia.etic effects of LR extra.t were eva.ua.ed based on histopa.hologica. exa.ina.ion a. well a. the mea.urement of blood glucose,insulin,gluca.on-like peptide 1(GLP-1),a.d lipid *** meta.olites were a.a.yzed using a. unta.geted meta.olomics *** a.cording to a.chemica. a.a.ysis,swertia.a.in,sweroside,hesperetin,couma.in,1.7-dihydroxy-3,8-dimethoxyl xa.thone,a.d 1-hydroxy-2,3,5 trimethoxa.one a.e the principa. a.tive ingredients in *** a.ti-dia.etic experiment revea.ed tha. the LR trea.ment significa.tly increa.ed pla.ma.insulin a.d GLP-1 levels while effectively lowering blood glucose,tota. cholesterol,triglycerides,low-density lipoprotein cholesterol,a.d ora. glucose tolera.ce test compa.ed to the model ***,unta.geted meta.olomic a.a.ysis of serum sa.ples detected 236 meta.olites,a.ong which 86 were differentia.ly expressed between the model a.d the LR *** wa. a.so found tha. LR considera.ly a.tered the levels of meta.olites such a. vita.in B6,meva.ona.e-5P,Dproline,L-lysine,a.d ta.rine,which a.e involved in the regula.ion of the vita.in B6 meta.olic pa.hwa.,selenium a.ino a.id meta.olic pa.hwa.,pyrimidine meta.olic pa.hwa.,a.d a.ginine a.d proline meta.olic *** These findings indica.ed tha. LR ma. ha.e a.hypoglycemic im

关键词： Mongolia. medicine Loma.ogonium rota.um Type 2 dia.etes Meta.olomics Swertia.a.in Streptozotocin

Ja.es P. a.lison received the 2014 Szent-Gyrgi Prize for Progress in Ca.cer Resea.ch

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Chinese Journa. of Ca.cer 2014年第9期33卷 416-420页

作者： Jie Zha. Peter Scully Sujua. ba Na.iona. Founda.ion for Ca.cer Resea.ch

The Szent-Gyrgyi Prize for Progress in Ca.cer Resea.ch is a.prestigious scientific a.a.d esta.lished by the Na.iona. Founda.ion for Ca.cer Resea.ch(NFCR)—a.lea.ing ca.cer resea.ch cha.ita.le orga.iza.ion in the United Sta.es tha. is committed to supporting innova.ive ca.cer resea.ch on the global sca.e tha. a.ms to cure ca.cer. Ea.h yea., the Szent-Gyrgyi Prize honors a. outsta.ding resea.cher whose origina. discoveries ha.e expa.ded our understa.ding of ca.cer a.d resulted in nota.le a.va.ces in ca.cer prevention, dia.nosis, or trea.ment. The prize a.so promotes public a.a.eness of the importa.ce of basic ca.cer resea.ch a.d encoura.es the susta.ned investment needed to a.celera.e the tra.sla.ion of these resea.ch discoveries into new ca.cer trea.ments. This report highlights the history a.d mission of the Szent-Gyrgyi Prize, its role in promoting discovery-oriented ca.cer resea.ch, a.d the pioneering work led by the 2014 prize winner, Dr. Ja.es a.lison. Dr. a.lison's work in the a.ea.of ca.cer immunothera.y led to the successful development of immune checkpoint thera.y, a.d the first drug a.proved by the United Sta.es Food a.d Drug a.ministra.ion for the trea.ment of meta.ta.ic mela.oma.

关键词：癌症治疗美国食品免疫治疗全球范围研究人员黑色素瘤基金会获奖者