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Clinical Experience of Professor du Xiaoquan's Treatment of Spleen and Spleen Disease

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Journal of Clinical and Nursing Research 2021年第2期5卷 105-107页

作者： Chenhuan Pang Xiaoquan du Shaanxi University of Traditional Chinese Medicine Shaanxi ProvinceChina Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina

Professor du Xiaoquan is a famous Chinese medicine in Shaanxi Province,a master's tutor,a professor of Shaanxi University of traditional Chinese Medicine,a director of the Department of traditional Chinese Medicine,an... 详细信息

关键词： Spleen and stomach disease Differentiation of disease and differentiation of body Drugto-drug ratio Prevention and care

Selections from Mr. du Xiao-shan's Clinical Experience in Acupuncture

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Journal of Acupuncture and Tuina Science 2003年第6期1卷 3-5页

作者： du Liang-dong XIAO Yuan-chun TCM Hospital of Wuxi City Jiangsu China 214001

du Xiao-shan, senior consult doctor, visiting professor of Nanjing University of TCM, tutor of the successor of senior TCM experts' experience, and he is granted the special allowance of State DepartmentMr. du Xiao-shan has been engaged in medical practice for more than sixty years. He has a good command of medical theories and excellent skills of clinical practice. Diagnostically, he combines syndrome differentiation and disease differentiation; therapeutically, he prescribes acupoints and needling techniques in accordance with the etiology and pathogenesis. Especially, he develops and refines some needling techniques on the basis of the classic ones, which are of great value in his clinical practice. I have been following Mr. du for a long time and achieved certain success. I now present several proven prescriptions below.Author: du Liang-dong (1957-), male, attending physicianTranslator: X{upiao} Yuan-chun

关键词： clinical practice syndrome differentiation

Professor Yumao du's Experience in Treating Chronic Nephritis

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Proceedings of Anticancer Research 2021年第4期5卷 30-33页

作者： Yang Zhou Wei Leng Zhifeng du Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina Academic School Inheritance Studio of Shaanxi du's Kidney Disease Yumao HospitalXianyang 712000Shaanxi ProvinceChina

Chronic nephritis is a common clinical kidney disease,with insidious onset and long course,which can eventually develop into chronic renal *** Chinese medicine,it belongs to the categories of"edema,""back pain""deficiency,"and epertigo."Professor du Yumao is a well-known Chinese medicine doctor and a well-known nephropathy expert in *** has rich clinical experience and unique insights into the treatment of chronic *** believes that insufficient kidney yin is the key to this disease,and water dampness and blood stasis are important pathological *** change of method according to the situation and flexible use of medicine often lead to good clinical outcomes.

关键词： Yumao du Chronic nephritis Clinical experience

Network Pharmacology of Xian-Lian-Jie-du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： Ming-Xia Zhao Cheng-Lin Song Qin-Chang Zhang Hao-Jie du Shu-Qiong Zhang Yu-Xian Shen Yang Sun Hai-Bo Cheng Wen Lv Department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina Department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina Department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the Xian-Lian-Jie-du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology Xian-Lian-Jie-du decoction

Professor du Xiaoquan's Experience in Treating Acid Reflux

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Proceedings of Anticancer Research 2021年第4期5卷 108-111页

作者： Wei Cui Li Liu Xiaoquan du Chunxia Ma Xuzhao Wang Shaanxi University of Chinese Medicine Xianyang 712046Shaanxi ProvinceChina The First Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712046Shaanxi ProvinceChina

Acid regurgitation is a common symptom in digestive system diseases which is mainly caused by emotions,diet,and other *** is related to gastroesophageal reflux disease,chronic gastritis,and other diseases in Western *** to modem medical research,acid reflux is related to Helicobacter pylori(HP)infection,weak effect of anti-reflux barrier,decreased clearance of esophageal acid,dysfunction of esophageal mucosal barrier,strong stimulation of reflux on esophageal mucosal wall,and other factors[1].It can be divided into four types which are heat,cold,food stagnation,and yin deficiency It is often accompanied by vomiting,heartbum,stomachache,and other ***,it is a mixture of cold and heat,as well as excess and *** du's self-made method of“first soothing,second reducing,and third harmonizmg”(soothing liver and stomach,relieving stomach qi,and neutralizing stomach acid)is used to treat both,symptoms and the root *** commonly used prescriptions are left-running metal pill,cuttlefish bone and fritillaria powder,calcined ark shell,oyster shell,etc.

关键词： Acid regurgitation Stomach Cold

灭活芽孢杆菌du-106对秀丽隐杆线虫的抗衰老作用

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食品科学 2023年第23期44卷 134-141页

作者：张余威赵文俊李伟杰杜冰黎攀华南农业大学食品学院广东广州510642

本研究探讨灭活芽孢杆菌du-106对秀丽隐杆线虫体内抗衰老作用及机制。将芽孢杆菌du-106进行灭活处理,利用体外自由基清除能力评价灭活芽孢杆菌du-106的体外抗氧化活性;并基于秀丽隐杆线虫为模型,观察不同质量浓度灭活芽孢杆菌du-106对... 详细信息

本研究探讨灭活芽孢杆菌du-106对秀丽隐杆线虫体内抗衰老作用及机制。将芽孢杆菌du-106进行灭活处理,利用体外自由基清除能力评价灭活芽孢杆菌du-106的体外抗氧化活性;并基于秀丽隐杆线虫为模型,观察不同质量浓度灭活芽孢杆菌du-106对线虫寿命、应激能力、体内抗氧化能力等指标的影响。结果表明,灭活芽孢杆菌du-106具有较强的体外自由基清除能力。同时,灭活芽孢杆菌du-106有效延长了秀丽隐杆线虫的寿命、提高了线虫活力和抗应激能力。不同质量浓度的灭活芽孢杆菌du-106提高了线虫体内过氧化氢酶、超氧化物歧化酶和谷胱甘肽的水平,并呈一定的剂量依赖性。荧光显微镜显示灭活芽孢杆菌du-106处理有效降低了秀丽隐杆线虫脂褐素水平。综上,灭活芽孢杆菌du-106可能是通过减轻秀丽隐杆线虫体内脂褐素堆积和提高其体内抗氧化酶水平,从而发挥抗衰老作用。本研究可为今后芽孢杆菌的开发与利用提供一定依据,有利于系列食品保健品的生产。

关键词：芽孢杆菌du-106 秀丽隐杆线虫抗衰老抗氧化

黄鱼鱼鳔肽分离及其诱导前列腺癌du-145细胞凋亡的机制

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中国食品学报 2023年第2期23卷 72-82页

作者：彭东赖玉健田柬昕钟碧銮安苗青黎攀杜冰华南农业大学食品学院广州510642 广东参之源健康科技有限公司广州510000 华南农业大学与官栈鱼胶营养安全研究中心广州510642

为探讨黄鱼鱼鳔肽诱导前列腺癌du-145细胞凋亡的作用机制,从黄鱼鱼鳔酶解产物中分离纯化得到鱼鳔肽,鉴定其氨基酸序列。采用CCK-8法检测鱼鳔肽作用后du-145细胞抑制率的变化;AO/EB法检测du-145细胞凋亡情况;流式细胞术检测du-145细胞凋... 详细信息

为探讨黄鱼鱼鳔肽诱导前列腺癌du-145细胞凋亡的作用机制,从黄鱼鱼鳔酶解产物中分离纯化得到鱼鳔肽,鉴定其氨基酸序列。采用CCK-8法检测鱼鳔肽作用后du-145细胞抑制率的变化;AO/EB法检测du-145细胞凋亡情况;流式细胞术检测du-145细胞凋亡率和周期;免疫印记法检测du-145细胞凋亡蛋白表达。结果表明,分离得到的鱼鳔肽YCSB-1c中包含Ser-Pro-Ser-Pro和Gly-Pro-Ala-Arg两条寡肽。与空白组相比,YCSB-1c组中凋亡细胞明显增多,且呈质量浓度依赖性;流式细胞仪检测得出YCSB-1c组中存活细胞明显减少,晚期凋亡细胞明显增多。YCSB-1c将du-145细胞的细胞周期阻滞在G0/G1期,上调Bax、Caspase-3及Caspase-9蛋白表达,诱导du-145细胞凋亡。YCSB-1c能有效诱导du-145细胞凋亡,其作用机制与细胞周期停滞和线粒体介导的凋亡途径有关。

关键词：黄鱼鱼鳔抗前列腺癌肽 du-145细胞凋亡机制

解三维扩散方程的du Fort-Frankel差分格式题

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衡水学院学报 2008年第4期10卷 4-6页

作者：杜林娟曲小钢西安建筑科技大学理学院陕西西安710055

为了解三维扩散方程,将一维扩散方程的du Fort-Frankel差分格式推广到三维,得到了三维扩散方程的du Fort-Frankel差分格式,证明了这种差分格式是绝对稳定的.

关键词：三维扩散方程差分格式截断误差稳定性显式格式

Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期 226-232页

作者： Rongrong du Senmiao Xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

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