Enantio-divergent C–H borylation with two different ligands from a single chiral source

作     者：Rongrong Du Senmiao Xu 

作者机构：State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences 

出 版 物：《Science China Chemistry》 (中国科学:化学(英文版))

年 卷 期：2025年第1期

页      面：226-232页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Key R&D Program of China (2022YFA1504302) the National Natural Science Foundation of China (92256302, 22331011) the Natural Science Foundation of Jiangsu Province (BK20211092) the Major Program of the Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences (ZYFZFX-9) the Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences the Hangzhou Normal University 

摘      要：Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.