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Cholinergic neuromuscular junctions in Brachionus calyciflorus and Lecane quadridentata(Rotifera:Monogononta)

Journal of Coastal Life Medicine 2014年第5期 376-381页

作者： Ignacio Alejandro Pérez-Legaspi alma lilián guerrero-barrera Iván JoséGalván-Mendoza JoséLuis Quintanar Roberto Rico-Martínez Graduate Studies and Research Division Boca del Río Institute of TechnologyKm.12 Carr.Veracruz–Córdoba94290Boca del RíoVer.México Morphology Department Basic Sciences CenterAguascalientes Autonomous UniversityAve.Universidad 940Aguascalientes20100México Confocal Microscopy Unit Experimental Services DepartmentCINVESTAV-ZacatencoNational Politechnic InstituteAve.Politécnico2508Zacatenco56000MéxicoD.F.México Pharmacology and Physiology Department Aguascalientes Autonomous UniversityAve.Universidad 940Aguascalientes20100México Chemistry Department Basic Sciences CenterAguascalientes Autonomous UniversityAve.Universidad 940Aguascalientes20100México

Objective:To identify the presence of joint muscular and cholinergic systems in two freshwater rotifer species,Brachionus calyciflorus and Lecane ***:The muscle actin fibers were stained with phalloidin-linked fluorescent dye,and acetylcholine was detected with Amplex Red Acetylcholine/Acetylcholinesterase Assay Kit,and then confocal scanning laser microscopy was ***:The musculature of Brachionus calyciflorus showed a pattern similar to other species of the same genus,while that of Lecane quadridentata was different from other rotifer genera described *** cholinergic system was determined by co-localization of both muscles and acetylcholine labels in the whole rotifer,suggesting the presence of neuromuscular ***:The distribution pattern of muscular and acetylcholine systems showed considerable differences between the two species that might be related to different adaptations to particular ecological *** confirmation of a cholinergic system in rotifers contributes to the development of potential neuro-pharmacological and toxicological studies using rotifers as model organism.

关键词： Acetylcholine Co-localization Confocal microscopy F-actin Rotifer

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Research on Stock Price Prediction Method Based on the GAn-LSTM-Attention Model

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Computers, Materials & Continua 2025年第1期82卷 609-625页

作者： Peng Li Yanrui Wei lili Yin College of Computer Science and Technology Harbin University of Science and TechnologyHarbin150006China

Stock price prediction is a typical complex time series prediction problem characterized by dynamics,nonlinearity,and *** paper introduces a generative adversarial network model that incorporates an attention mechanism(GAn-LSTM-Attention)to improve the accuracy of stock price ***,the generator of this model combines the Long and Short-Term Memory network(LSTM),the Attention Mechanism and,the Fully-Connected Layer,focusing on generating the predicted stock *** discriminator combines the Convolutional neural network(Cnn)and the Fully-Connected Layer to discriminate between real stock prices and generated stock ***,to evaluate the practical application ability and generalization ability of the GAn-LSTM-Attention model,four representative stocks in the United States of America(USA)stock market,namely,Standard&Poor’s 500 Index stock,Apple Incorporatedstock,AdvancedMicroDevices Incorporatedstock,and Google Incorporated stock were selected for prediction experiments,and the prediction performance was comprehensively evaluated by using the three evaluation metrics,namely,mean absolute error(MAE),root mean square error(RMSE),and coefficient of determination(R2).Finally,the specific effects of the attention mechanism,convolutional layer,and fully-connected layer on the prediction performance of the model are systematically analyzed through ablation *** results of experiment show that the GAn-LSTM-Attention model exhibits excellent performance and robustness in stock price prediction.

关键词： Stock price prediction generative adversarial network attention mechanism time-series prediction

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun Yang lili Guo Ruxiang Xu Department of neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of neurosurgery Chinese PLA General HospitalBeijingChina Department of neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion

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Green Energy & Environment 2025年第1期10卷 109-131页

作者： Wei Ma Jiahao Yao Fang Xie Xinqi Wang Hao Wan Xiangjian Shen lili Zhang Menggai Jiao Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityHenan450001China

Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic *** introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active *** optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of *** elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization ***,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/n_(2) reduction reactions by integrating mechanisms from diverse *** underscores the pivotal role of point defects in enhancing catalytic *** last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials.

关键词： Point defect engineering Doping Vacancy Electrocatalysis Electronic structure

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乡村文化振兴促进农民精神生活共同富裕的优势、障碍与进路

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 36-43页

作者：贺莉莉西安理工大学马克思主义学院西安710048

共同富裕是中国特色社会主义的本质要求,是人民群众的共同期盼。共同富裕旨在实现生活品质全面提升,不仅追求物质层面的富饶与充裕,而且强调精神世界的丰富与满足,即物质富足与精神充实和谐并进。随着中国特色社会主义迈向新发展阶段,... 详细信息

共同富裕是中国特色社会主义的本质要求,是人民群众的共同期盼。共同富裕旨在实现生活品质全面提升,不仅追求物质层面的富饶与充裕,而且强调精神世界的丰富与满足,即物质富足与精神充实和谐并进。随着中国特色社会主义迈向新发展阶段,积极培育并激发农民精神生活共同富裕,有助于提升农民文化底蕴与道德修养,为乡村文化振兴提供强大精神动力和智力支持,从而推动乡村社会全面发展与繁荣。乡村文化振兴是解决城乡人民精神文化生活发展不平衡问题的重要手段,是促进农民精神生活共同富裕的关键途径。乡村文化振兴具有统一思想认识、培育乡风文明、实现精神自强等显著优势,为农民精神生活共同富裕提供思想基础、文化资源和内生动力。然而,囿于农民综合素养不高、乡村文化价值在多元文化碰撞中日渐式微以及文化振兴载体建设不畅等现实障碍,农民精神生活共同富裕的任务任重而道远。为此,应通过强化宣传教育、推动乡村文化融入社会主义文化繁荣大局之中、建设乡村新时代文明实践中心等举措,充分发挥乡村文化振兴在促进农民精神生活共同富裕中的重要作用。

关键词：乡村文化振兴农民精神生活共同富裕

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Optimization Model for Inter-regional Emergency Power Dispatch Considering Transmission Rights Allocation

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Dianwang Jishu/Power System Technology 2025年第1期49卷 223-231页

作者： Guan, Jinyu Liang, Zhifeng Chang, Li Cao, Rongzhang Li, lili nARI Group Corporation State Grid Electric Power Research Institute Jiangsu Province Nanjing 211106 China nARI Technology Co. Ltd. Jiangsu Province Nanjing 211106 China Department of Electrical Engineering Tsinghua University Haidian District Beijing 100084 China national Power Dispatch and Control Centre Xicheng District Beijing 100031 China

Inter-regional emergency power dispatch refers to the mandatory fallback guarantee measures for ensuring supply or absorption of emergency demands within provincial grids when market-based approaches have been exhausted from the perspective of mutual assistance in electricity surplus and shortage across provinces and regions. When it is impossible to rely on market declarations directly, how to allocate emergency demands and inter-provincial/regional support capacities and distribute the limited available transfer capacity reasonably among market entities is one of the key issues urgently needing to be addressed in current emergency dispatch. This paper proposes an optimization model for inter-provincial and inter-regional emergency power dispatch considering transmission rights. Inspired by China's current mechanism for allocating transmission channel revenue rights, based on local prioritization and the urgency of emergency demands, a method for determining the priority of emergency transactions considering transmission rights allocation is proposed. This method transforms transmission rights into priority transaction rights, addressing the lack of a reasonable basis for transmission capacity allocation in the emergency dispatch phase. Considering constraints such as available transfer capacity, transaction flow balance, and transaction point power balance constraints, to maximize adjusted social welfare, a clearing model for emergency dispatch optimization considering transaction path priority is constructed. Comparative analysis of the optimization results of three 1e clearing modes, price-based sequential clearing, scenario-based separation, and clearing with transaction path priority, validates the effectiveness and superiority of the proposed optimization clearing model and analyzes the impact of related parameter settings on the clearing results. © 2025 Power System Technology Press. All rights reserved.

关键词： Commerce

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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