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Catechins Green Tea GMB4 Clone Increases mRNA of ABCA1 through LXR Signaling in Cultured Macrophage Exposed OX-LDL

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Food and Nutrition Sciences 2019年第9期10卷 1179-1190页

作者： Erna Susanti Retty Ratnawati Aulanni’am Aulanni’am Achmad Rudijanto Pharmacy and Food Analysis Academy “Putra Indonesia Malang” Malang Indonesia Doctoral Program of Biomedical Science Medical Faculty Brawijaya University Malang Indonesia

Inhibition of atherogenesis through inhibition of lipid metabolism has not been explored while other inhibitions through inflammation, endothelial dysfunction and free radicals have done. Inhibition of atherogenesis via inhibition of lipid metabolism can be done through the mechanism of Reverse Cholesterol Transport (RCT). Signaling pathways that play a role in this mechanism is LXR signaling. LXR activation by an LXR agonist led increasing cholesterol efflux. Catechins based on bioinformatics study showed as a potent candidate LXR agonists that can be used as an inhibitor of atherogenesis. This study aims to prove that the administration Catechins green tea Clone GMB4 can prevent atherosclerosis through increasing mechanism cholesterol efflux from macrophage by taking effect of ABCA1, ABCG1, SRB1 gene expression in cultured macrophages were exposed ox-LDL. Long-term goals of the outcome of the research are the use of Catechins Green Tea Clones GMB4 as an inhibitor of atherogenesis so that it can be used as a complementary therapy for the treatment of atherosclerosis and cardiovascular diseases. The research is divided into 5 groups, namely the culture of macrophages without exposed ox-LDL, culture exposed ox-LDL and groups of Catechins dose I, II, III. In vitro study showed that administration of Catechins increases mRNA of ABCA1, whereas mRNA ABCG1 and SRB1 decreased at all three doses given. The result of protein profilling was identified a protein with a molecular weight of 70 kDa by SDS-PGE with silver staining.

关键词： Atherogenesis Catechins ABCA1 ABCG1 Dan SRB1 Cultured Macrophage

Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy

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World Journal of Gastroenterology 2016年第47期22卷 10465-10470页

作者： Maartje M van de Meeberg Lauranne AAP Derikx Harm am Sinnige Peet Nooijen D Lucette Schipper Loes HC Nissen Department of Gastroenterology and Hepatology Jeroen Bosch Hospital Department of Hematology Jeroen Bosch Hospital Department of Pathology Jeroen Bosch Hospital

Hepatosplenic T-cell lymphoma(HSTCL) is a rare nonHodgkin lymphoma with a high mortality rate. Higher incidence is reported in patients with inflammatory bowel disease, specifically in male patients that are younger than 35 years, and have been treated with thiopurine and tumor necrosis factor(TNF)-α inhibitor combination therapy for over 2 years. In this case report we describe a 47-year-old patient with Crohn's disease(CD) who developed HSTCL after having been treated with thiopurine monotherapy for 14 years. To our best knowledge, only eleven cases exist of patients with CD who developed HSTCL while on thiopurine monotherapy. We report the first patient with CD, older than 35 years, who developed HSTCL while on thiopurine monotherapy. This emphasizes that HSTCL risk is not limited to young men receiving both thiopurines and TNF-α inhibitors.

关键词： Hepatosplenic T-cell lymphoma Thiopurine Crohn’s disease Immunosuppression

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大肠手法和钉书机吻合后的结、直肠癌复发

国际外科学杂志 1992年第3期23卷 191-192页

作者： Akyol am

有关大肠癌切除后采用手法或钉书机吻合的利弊,各家的看法尚不一致。为了比较这两种吻合方法对癌肿复发的影响,作者综合收集了1985～1989年苏格兰5家医院13位外科医师连续施行的463例结、直肠癌病例,重点对其中治愈性切除和随访资料完整... 详细信息

有关大肠癌切除后采用手法或钉书机吻合的利弊,各家的看法尚不一致。为了比较这两种吻合方法对癌肿复发的影响,作者综合收集了1985～1989年苏格兰5家医院13位外科医师连续施行的463例结、直肠癌病例,重点对其中治愈性切除和随访资料完整的294例进行分析。每年内窥镜检查肠吻合处情况。

关键词：钉书机吻合方法直肠癌肿瘤复发手法吻合内窥镜检查外科医师吻合部位大肠癌肿瘤分期

Acquired aortocameral fistula occurring late after infective endocarditis: An emblematic case and review of 38 reported cases

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World Journal of Cardiology 2016年第8期8卷 488-495页

作者： Salah am Said Massimo A Mariani Department of Cardiology Hospital Group Twente Thorax Centre Department of Cardiac Surgery University Medical Center Groningen

AIM To delineate the features and current therapeutic option of congenital and acquired aortocameral fistulas(ACF) secondary to iatrogenic or infectious *** From a Pub Med search using the term "aortocameral fistula", 30 suitable papers for the current review were retrieved. Reviews, case series and case reports published in English were considered. Abstracts and reports from scientific meetings were not included. A total of 38 reviewed subjects were collected and analyzed. In addition, another case- an adult male who presented with ACF between commissures of the right and noncoronary sinuses and right atrium as a late complication of Staphylococcus aureus infective endocarditis of the AV- is added, the world literature is briefly *** A total of thirty-eight subjects producing 39 fistulas were reviewed, analyzed and stratified into either congenital(47%) or acquired(53%) according to their etiology. Of all subjects, 11% were asymptomatic and 89% were symptomatic with dyspnea(21 ×) as the most common presentation. Diagnosis was established by a multidiagnostic approach in 23(60%), single method in 14(37%)(echocardiography in 12 and catheterization in 2), and at autopsy in 2(3%) of the subjects. Treatment options included percutaneous transcatheter closure in 12(30%) with the deployment of the amplatzer duct or septal occluder and Gianturco coil and surgical correction in 24(63%). CONCLUSION Acquired ACF is an infrequent entity which may occur late after an episode of endocarditis of the native AV. The management of ACF is generally by surgical correction but non-surgical device intervention has recently been introduced as a safe alternative.

关键词： Aortic-atrial shunt Aortic-atrial fistulas Infective endocarditis Late complication Surgical correction

Impact of a Principal＇s Leadership Style on School Organizational Climate in an Arab School in Israel

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Chinese Business Review 2016年第11期15卷 538-546页

作者： Osama Arar Ran Bar-am West University of Timisoara Timisoara Romania

The study aimed at examining by quantitative research design to what extent management style affects organizational climate of schools A, B, and C of Arab sector in Israel, while comparing a test group of school A to a control group of schools B＋C. The research question was： What is the impact of a principal＇s management style on creation of a positive school organizational climate？ Quantitative data collection was conducted by means of validated questionnaires from relevant scientific literature. The findings indicate that a principal has a central role in a teacher＇s perception of professional autonomy. The sense of professional autonomy of a teacher is reinforced the more a teacher senses that the principal is an educational figure or a leader whom he can consult with regarding personal and professional problems. Differences were found among teachers in perception of school characteristics as providing various levels of autonomy.

关键词： management styles authoritative-centralized democratic-decentralizing organizational climate

Optical diagnosis of colorectal polyps using high-definition i-scan: An educational experience

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World Journal of Gastroenterology 2013年第27期19卷 4334-4343页

作者： Mariёlle WE Bouwens Rogier de Ridder Ad am Masclee Ann Driessen Robert G Riedl Bjorn Winkens Silvia Sanduleanu Division of Gastroenterology and Hepatology Department of Internal MedicineMaastricht University Medical Center NUTRIM School for NutritionToxicology and MetabolismMaastricht University Medical Center Department of Pathology Maastricht University Medical Center Department of Methodology and Statistics Maastricht University Medical Center GROW School for Oncology and Developmental BiologyMaastricht University Medical Center

AIM:To examine performances regarding prediction of polyp histology using high-definition (HD) i-scan in a group of endoscopists with varying levels of experience. METHODS:We used a digital library of HD i-scan still images, comprising twin pictures (surface enhancement and tone enhancement), collected at our university hospital. We defined endoscopic features of adenomatous and non-adenomatous polyps, according to the following parameters:color, surface pattern and vascular pattern. We familiarized the participating endoscopists on optical diagnosis of colorectal polyps using a 20-min didactic training session. All endoscopists were asked to evaluate an image set of 50 colorectal polyps with regard to polyp histology. We classified the diagnoses into high confidence (i.e., cases in which the endoscopist could assign a diagnosis with certainty) and low confidence diagnoses (i.e., cases in which the endoscopist preferred to send the polyp for formal histology). Mean sensitivity, specificity and accuracy per endoscopist/image were computed and differences between groups tested using independent-samples t tests. High vs low confidence diagnoses were compared using the pairedsamples t test. RESULTS:Eleven endoscopists without previous experience on optical diagnosis evaluated a total of 550 images (396 adenomatous, 154 non-adenomatous). Mean sensitivity, specificity and accuracy for diagnosing adenomas were 79.3%, 85.7% and 81.1%, respectively. No significant differences were found between gastroenterologists and trainees regarding performances of optical diagnosis (mean accuracy 78.0%vs 82.9%,P = 0.098). Diminutive lesions were predicted with a lower mean accuracy as compared to non-diminutive lesions (74.2% vs 93.1%, P = 0.008). A total of 446 (81.1%) diagnoses were made with high confidence. High confidence diagnoses corresponded to a significantly higher mean accuracy than low confidence diagnoses (84.0% vs 64.3%, P = 0.008). A total of 319 (58.0%) images were evalu

关键词： Colonoscopy High-definition i-scan Optical diagnosis Colorectal polyps Training

Thoughts about cancer stem cells in solid tumors

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World Journal of Stem Cells 2012年第3期4卷 17-20页

作者： Caterina am La Porta Department of Biomolecular Science and Biotechnology University of Milan via Celoria 26 20133 Milan Italy

Cancer chemotherapy efficacy is frequently impaired by either intrinsic or acquired tumor resistance.A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue *** recent years,the cancer stem cell(CSC) theory has changed the classical view of tumor growth and therefore the therapeutic *** intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic *** the other hand,the identification of CSCs in vivo and in vitro relies on specific surface markers that should allow the sorting cancer cells into phenotypically distinct *** the present review,recent papers published on CSCs in solid tumors(breast,prostate,brain and melanoma) are discussed,highlighting critical points such as the choice of markers to sort CSCs and mouse models to demonstrate that CSCs are able to replicate the original tumor.A discussion of the possible role of aldehyde dehydrogenase and CXCR6 biomarkers as signaling molecules in CSCs and normal stem cells is also *** author believes that efforts have to be made to investigate the functional and biological properties of putative CSCs in *** diagnostic/prognostic tools to follow cancer development is also a *** this connection it would be useful to develop a multidisciplinary approach combining mathematics,physics and biology which merges experimental approaches and *** models alone are probably unable to resolve the problem completely.

关键词： Cancer stem cells Tumor Asymmetric self renewal Biomarkers

Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation

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World Journal of Gastroenterology 2007年第5期13卷 657-670页

作者： D Gomez S Homer-Vanniasinkam am Graham KR Prasad Department of Hepatobiliary Surgery and Transplantation St. James’s University Hospital United Kingdom Department of Vascular Surgery Leeds General Infirmary Leeds United Kingdom Department of Biomedical Sciences University of Bradford Bradford United Kingdom

Liver ischaemic preconditioning （IPC） is known to protect the liver from the detrimental effects of ischaemic-reperfusion injury （IRI）, which contributes significantly to the morbidity and mortality following major liver surgery. Recent studies have focused on the role of IPC in liver regeneration, the precise mechanism of which are not completely understood. This review discusses the current understanding of the mechanism of liver regeneration and the role of IPC in this setting. Relevant articles were reviewed from the published literature using the Medline database. The search was performed using the keywords ＂liver＂, ＂ischaemic reperfusion＇, ＂ischaemic preconditioning＂, ＂regeneration＂, ＂hepatectomy＂ and ＂transplantation＂. The underlying mechanism of liver regeneration is a complex process involving the interaction of cytokines, growth factors and the metabolic demand of the liver. IPC, through various mediators, promotes liver regeneration by up-regulating growth-promoting factors and suppresses growth-inhibiting factors as well as damaging stresses. The increased understanding of the cellular mechanisms involved in IPC will enable the development of alternative treatment modalities aimed at promoting liver regeneration following major liver resection and transplantation.

关键词： Liver regeneration Ischaemic reperfusion Lschaemic preconditioning Hepatectomy Transplantation

The Role of Secondary School Teacher Training in Their Teaching Practices-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第4期8卷 328-345页

作者： amélie Duguet Sophie Morlaix Institute for Research on Education(IREDU) University of Burgundy Franche-ComtéFrance

This work aims to analyze the effect exerted by the initial and continuous training of secondary school teachers in France on their teaching *** this,we carried out a secondary analysis of data from the TALIS survey(Teaching and Learning International Survey),conducted in 2013 in 34 countries,including *** particular,we focus on practices related to the teaching methods used,classroom management,how to communicate,and the evaluative practices of *** support of binary logistic regression models,we showed that the variables related to initial training play a weak role,and even exert a negative effect on certain pedagogic practices,leading to a reflection on the renovation of this *** the other hand,our analyses highlighted the greater weight played by certain continuing education actions.

关键词： Teacher training Pedagogy methods and tools Analysis of professional practice