关于在稳固的肿瘤的癌症干细胞的想法
Thoughts about cancer stem cells in solid tumors作者机构：Department of Biomolecular Science and Biotechnology University of Milan via Celoria 26 20133 Milan Italy
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2012年第4卷第3期
页 面：17-20页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cancer stem cells Tumor Asymmetric self renewal Biomarkers
摘 要：Cancer chemotherapy efficacy is frequently impaired by either intrinsic or acquired tumor resistance.A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue *** recent years,the cancer stem cell(CSC) theory has changed the classical view of tumor growth and therefore the therapeutic *** intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic *** the other hand,the identification of CSCs in vivo and in vitro relies on specific surface markers that should allow the sorting cancer cells into phenotypically distinct *** the present review,recent papers published on CSCs in solid tumors(breast,prostate,brain and melanoma) are discussed,highlighting critical points such as the choice of markers to sort CSCs and mouse models to demonstrate that CSCs are able to replicate the original tumor.A discussion of the possible role of aldehyde dehydrogenase and CXCR6 biomarkers as signaling molecules in CSCs and normal stem cells is also *** author believes that efforts have to be made to investigate the functional and biological properties of putative CSCs in *** diagnostic/prognostic tools to follow cancer development is also a *** this connection it would be useful to develop a multidisciplinary approach combining mathematics,physics and biology which merges experimental approaches and *** models alone are probably unable to resolve the problem completely.
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