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Surface integrity of ball burnished bioresorbable magnesium alloy

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Advances in Manufacturing 2023年第2期11卷 342-362页

作者： G.V.jagadeesh Srinivasu Gangi Setti Department of Mechanical Engineering National Institute of Technology RaipurChhattisgarh492010India

Magnesium alloys are potential biodegradable and biocompatible implant materials because of their excellent biological properties. Recently, interest in these alloys as a promising alternative for temporary orthopedic implants has grown owing to their desirable biological, mechanical, and physical properties. However, the application of magnesium alloys is hindered by their rapid degradation and low corrosion resistance in physiological fluids, leading to the failure of implants. Thus, the current challenge is to enhance the corrosion resistance and control the degradation rate of magnesium under physiological conditions. The rapid degradation of magnesium alloys can be controlled by improving their surface integrity, such as surface roughness and microhardness. The present study aims to improve the surface integrity of the Mg Ze41A alloy by the ball burnishing technique. The surface roughness improved by 94.90% from 0.941 μm to 0.048 μm with a burnishing force of 50 N, burnishing speed of 1 300 r/min, burnishing feed of 130 mm/min, and three passes. Similarly, the microhardness improved by 50.62% from 75.2 HV to 113.27 HV with a burnishing force of 60 N, burnishing speed of 1 100 r/min, burnishing feed of 100 mm/min, and five passes. The variations in microhardness, which were observed up to 400 μm beneath the surface, exhibited a linear nature. These variations may be attributed to the movement of dislocations, formation of new dislocations, nanocrystal structures, metastable phases and subgrains, and lattice distortion or grain refinement. The surface features obtained from optical images demonstrated the fundamental mechanisms involved in the ball burnishing process. The concept of burnishing maps and zones will assist in the design of the ball burnishing parameters of a material with an equivalent yield strength of 140 MPa. The significant improvement in the surface integrity of the Mg Ze41A alloy by the ball burnishing technique is expected to improve its func

关键词： Magnesium alloy Bioresorbable Orthopedic implants Surface integrity Ball burnishing

For antigen-specific effector or Foxp3^(+) regulatory T cell fate, cyclin-dependent kinases hold the trump card

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Cellular & Molecular Immunology 2020年第4期17卷 310-312页

作者： Srinivasa Reddy Bonam jagadeesh Bayry Neuroimmunology&peptide therapy Biotechnology and cell signalingCNRS-University of StrasbourgIllkirch 67412 StrasbourgFrance Institut National de la Santéet de la Recherche Médicale Centre de Recherche des CordeliersEquipe-Immunopathologie et Immunointervention ThérapeutiqueSorbonne UniversitéUniversitéParis DescartesSorbonne Paris CitéParis F-75006France

Forkhead box p3^(+)(Foxp3^(+))regulatory T cells(Tregs)are indispensable for immune homeostasis and for maintaining immune *** studies have confirmed that injection of a T cell population depleted of Tregs causes autoimmunity,rejection of grafts and inflammatory disorders,whereas reconstitution with Tregs inhibits these pathogenic *** the last two decades,intense efforts have been made to identify Treg subsets,Treg differentiation processes,and the molecular signatures and regulators that determine Treg lineage specificity and stability.1–6 Several lines of evidence clearly demonstrate that Foxp3^(+)Tregs do not constitute a homogeneous population,and various subsets of Tregs,such as thymic Tregs(tTregs),in vitro-generated Tregs(iTregs),and peripherally induced Tregs(pTregs),have been identified.5 In addition to Foxp3,epigenetic factors and metabolic processes play key roles in maintaining Treg identity and function,and mediate the switch between effector T cells and Tregs.

关键词： Foxp3 specificity homeostasis

Experimental investigation and prediction of tribological behavior of unidirectional short castor oil fiber reinforced epoxy composites

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Friction 2021年第2期9卷 250-272页

作者： Rajesh EGALA G V jagadeesh Srinivasu Gangi SETTI Department of Mechanical Engineering National Institute of Technology RaipurChhattisgarh 492010India Department of Mechanical Engineering Gudlavalleru Engineering CollegeGudlavalleruAndhra Pradesh 521356India

The present study aims at introducing a newly developed natural fiber called castor oil fiber,termed ricinus communis,as a possible reinforcement in *** short castor oil fiber reinforced epoxy resin composites of different fiber lengths with 40%volume fraction were fabricated using hand layup *** sliding wear tests were performed on a pin-on-disc tribometer based on full factorial design of experiments(DoE)at four fiber lengths(5,10,15,and 20 mm),three normal loads(15,30,and 45 N),and three sliding distances(1,000,2,000,and 3,000 m).The effect of individual parameters on the amount of wear,interfacial temperature,and coefficient of friction was studied using analysis of variance(ANOVA).The composite with 5 mm fiber length provided the best tribological properties than 10,15,and 20 mm fiber length *** worn surfaces were analyzed under scanning electron ***,the tribological behavior of the composites was predicted using regression,artificial neural network(ANN)-single hidden layer,and ANN-multi hidden layer *** confirmatory test results show the reliability of predicted *** with multi hidden layers are found to predict the tribological performance accurately and then followed by ANN with single hidden layer and regression model.

关键词： natural fiber castor oil fiber epoxy composite full factorial design of experiments(DoE) analysis of variance(ANOVA) prediction regression artificial neural network(ANN)

Improved Model for Genetic Algorithm-Based Accurate Lung Cancer Segmentation and Classification

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Computer Systems Science & Engineering 2023年第5期45卷 2017-2032页

作者： K.jagadeesh A.Rajendran Department of Electronics and Communication Engineering SNS College of EngineeringCoimbatoreTamilnaduIndia Department of Electronics and Communication Engineering Karpagam College of EngineeringCoimbatoreTamilnaduIndia

Lung Cancer is one of the hazardous diseases that have to be detected in earlier stages for providing better treatment and clinical support to *** lung cancer diagnosis,the computed tomography(CT)scan images are to be processed with image processing techniques and effective classification process is required for appropriate cancer *** present scenario of medical data processing,the cancer detection process is very time consuming and *** that,this paper develops an improved model for lung cancer segmentation and classification using genetic *** the model,the input CT images are pre-processed with the filters called adaptive median filter and average *** filtered images are enhanced with histogram equalization and the ROI(Regions of Interest)cancer tissues are segmented using Guaranteed Convergence Particle Swarm Optimization *** classification of images,Probabilistic Neural Networks(PNN)based classification is *** experimentation is carried out by simulating the model in MATLAB,with the input CT lung images LIDC-IDRI(Lung Image Database Consortium-Image Database Resource Initiative)benchmark *** results ensure that the proposed model outperforms existing methods with accurate classification results with minimal processing time.

关键词： Cancer diagnosis segmentation enhancement histogram equalization probabilistic rate neural networks(PNN) classification

Restoration of established systemic inflammation and autoimmunity by Foxp3^(+) regulatory T cells

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Cellular & Molecular Immunology 2022年第2期19卷 133-135页

作者： Varun Kumar Sharma.jagadeesh Bayry Department of Biotechnology&Microbiology School of SciencesNoida International University-NIUGautam Budh Nagar-201308NoidaUttar PradeshIndia

Immune tolerance ensures the disease-free status of an individual by preventing the appearance of pathological conditions,such as autoimmune and inflammatory *** the various players implicated in the maintenance of immune tolerance,CD4^(+)CD25^(+)regulatory T(Treg)cells that express the X-linked transcription factor Forkhead box P3(Foxp3)play a major ***3 governs the functions of Treg *** fact,a deficiency in Treg cells due to mutations in FoxP3 leads to fatal autoimmune and inflammatory conditions in humans called immunodysregulation polyendocrinopathy enteropathy x-linked(IPEX)*** observations have also been made in mice,in which FoxP3 deficiency leads to autoimmune pathology and death early in *** addition,various mutations in Treg-associated immunoregulatory molecules lead to inflammatory conditions[1].

关键词： Foxp3 FoxP3 inflammation

mpaired regulatory T cell function in autoimmune Jiseases： are microRNAs the culprits？

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Cellular & Molecular Immunology 2016年第2期13卷 135-137页

作者： Varun K Sharma Srini V Kaveri jagadeesh Bayry Institut National de la Sante et de la Recherche Medicale Unit6 1138 Paris France Centre de Recherche des Cordeliers Equipe - Imm unopathology and therapeutic immunointervention Paris France International Associated Laboratory IMPACT Institut National de la Sante et de la Recherche Medicale Paris France and Indian Council of Medical Research India National Institute of Immuno- haematology Mumbai India Sorbonne Universites UPMC Univ Paris 06 UMR S 1138 Paris France Universite Paris Descartes Sorbonne Paris Cite UMR S 1138 Paris France

MicroRNAs （miRNAs） are evolu- tionarily conserved small non-coding RNA sequences, approximately 22 nucleotides in length, that act as negative regulators of target genes via binding to the 3＇-untranslated region of... 详细信息

关键词： microRNA 调节性T细胞免疫功能 miRNAs RNA序列 mRNA 非翻译区非编码

Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β

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Cellular & Molecular Immunology 2023年第1期20卷 8-10页

作者： Camille Chauvin Sruthi Vijaya Retnakumar jagadeesh Bayry Institut National de la Santéet de la Recherche Médicale Centre de Recherche des CordeliersSorbonne UniversitéUniversitéde Paris75006ParisFrance Department of Biological Sciences&Engineering Indian Institute of Technology PalakkadPalakkad678623India

Interleukin(IL)-33 is a nuclear cytokine in the IL-1 family that is constitutively expressed in the epithelial cells of environmentally exposed tissues(skin,gastrointestinal tract and lungs)and endothelial ***-33 is involved in type 2 innate immunity via the activation of eosinophils,basophils,mast cells,group 2 innate lymphoid cells and macrophages through its receptor ST2(also called IL1RL1)[1].Due to the absence of a secretory signal sequence,IL-33 was thought to be passively released during cell necrosis,physical stress or tissue damage and was accordingly considered an alarmin[2].

关键词： immunity Interleukin damage

Current perspectives on the role of liver transplantation for Langerhans cell histiocytosis:A narrative review

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World Journal of Gastroenterology 2022年第30期28卷 4044-4052页

作者： jagadeesh Menon Ashwin Rammohan Mukul Vij Naresh Shanmugam Mohamed Rela Institute of Liver Disease&Transplantation Dr.Rela Institute&Medical CentreBharath Institute of Higher Education&ResearchChennai 600044India

Langerhans cell histiocytosis(LCH)is a malignant disease of the histiocytes involving various organ *** spectrum of liver involvement in LCH ranges from mild transaminitis to end-stage liver *** hallmark of hepatic LCH is secondary sclerosing cholangitis,which manifests due to a progressive destruction of the biliary tree by malignant *** remains the mainstay of treatment for active *** recognition,diagnosis and a systematic approach to the management of LCH can ameliorate the disease ***,the liver involvement in these patients may progress despite the LCH being in *** transplantation(LT)remains central in the management of such *** facets of the management of LCH,especially those with liver involvement remain ***,aspects of LT in LCH with regards to the indication,timing and post-LT management,including immunosuppression and adjuvant therapy,remain *** review summarises the current evidence and discusses the practical aspects of the role of LT in the management of LCH.

关键词： Langerhans cell histiocytosis Liver transplantation Outcomes Management Chemotherapy Ethics

Induction of human dendritic cell maturation by naïve and memory B-cell subsets requires different activation stimuli

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Cellular & Molecular Immunology 2018年第12期15卷 1074-1076页

作者： Mohan S.Maddur Srini V.Kaveri jagadeesh Bayry Institut National de la Santéet de la Recherche Médicale Paris F-75006France Centre de Recherche des Cordeliers EquipeImmunopathologie et Immunointervention ThérapeutiqueParis F-75006France Sorbonne Université Paris F-75006France UniversitéParis Descartes Sorbonne Paris CitéParis F-75006France Present address:Pfizer Inc.Pearl RiverNew YorkNYUSA

Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune *** outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation *** we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.

关键词： activation immune maturation