Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β
作者机构:Institut National de la Santéet de la Recherche MédicaleCentre de Recherche des CordeliersSorbonne UniversitéUniversitéde Paris75006ParisFrance Department of Biological Sciences&EngineeringIndian Institute of Technology PalakkadPalakkad678623India
出 版 物:《Cellular & Molecular Immunology》 (中国免疫学杂志(英文版))
年 卷 期:2023年第20卷第1期
页 面:8-10页
核心收录:
学科分类:1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金:supported by a grant from the Agence Nationale de la Recherche France(ANR-19-CE17-0021(BASIN))
主 题:immunity Interleukin damage
摘 要:Interleukin(IL)-33 is a nuclear cytokine in the IL-1 family that is constitutively expressed in the epithelial cells of environmentally exposed tissues(skin,gastrointestinal tract and lungs)and endothelial ***-33 is involved in type 2 innate immunity via the activation of eosinophils,basophils,mast cells,group 2 innate lymphoid cells and macrophages through its receptor ST2(also called IL1RL1)[1].Due to the absence of a secretory signal sequence,IL-33 was thought to be passively released during cell necrosis,physical stress or tissue damage and was accordingly considered an alarmin[2].