Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β

作     者：Camille Chauvin Sruthi Vijaya Retnakumar Jagadeesh Bayry 

作者机构：Institut National de la Santéet de la Recherche MédicaleCentre de Recherche des CordeliersSorbonne UniversitéUniversitéde Paris75006ParisFrance Department of Biological Sciences&EngineeringIndian Institute of Technology PalakkadPalakkad678623India 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2023年第20卷第1期

页      面：8-10页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a grant from the Agence Nationale de la Recherche France(ANR-19-CE17-0021(BASIN)) 

主　　题：immunity Interleukin damage 

摘      要：Interleukin(IL)-33 is a nuclear cytokine in the IL-1 family that is constitutively expressed in the epithelial cells of environmentally exposed tissues(skin,gastrointestinal tract and lungs)and endothelial ***-33 is involved in type 2 innate immunity via the activation of eosinophils,basophils,mast cells,group 2 innate lymphoid cells and macrophages through its receptor ST2(also called IL1RL1)[1].Due to the absence of a secretory signal sequence,IL-33 was thought to be passively released during cell necrosis,physical stress or tissue damage and was accordingly considered an alarmin[2].