For antigen-specific effector or Foxp3^(+) regulatory T cell fate, cyclin-dependent kinases hold the trump card

作     者：Srinivasa Reddy Bonam Jagadeesh Bayry 

作者机构：Neuroimmunology&peptide therapyBiotechnology and cell signalingCNRS-University of StrasbourgIllkirch 67412 StrasbourgFrance Institut National de la Santéet de la Recherche MédicaleCentre de Recherche des CordeliersEquipe-Immunopathologie et Immunointervention ThérapeutiqueSorbonne UniversitéUniversitéParis DescartesSorbonne Paris CitéParis F-75006France 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2020年第17卷第4期

页      面：310-312页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by ANR-19-CE17-0021(BASIN) Institut National de la Santéet de la Recherche Médicale Sorbonne Université and UniversitéParis Descartes Paris France 

主　　题：Foxp3 specificity homeostasis 

摘      要：Forkhead box p3^(+)(Foxp3^(+))regulatory T cells(Tregs)are indispensable for immune homeostasis and for maintaining immune *** studies have confirmed that injection of a T cell population depleted of Tregs causes autoimmunity,rejection of grafts and inflammatory disorders,whereas reconstitution with Tregs inhibits these pathogenic *** the last two decades,intense efforts have been made to identify Treg subsets,Treg differentiation processes,and the molecular signatures and regulators that determine Treg lineage specificity and stability.1–6 Several lines of evidence clearly demonstrate that Foxp3^(+)Tregs do not constitute a homogeneous population,and various subsets of Tregs,such as thymic Tregs(tTregs),in vitro-generated Tregs(iTregs),and peripherally induced Tregs(pTregs),have been identified.5 In addition to Foxp3,epigenetic factors and metabolic processes play key roles in maintaining Treg identity and function,and mediate the switch between effector T cells and Tregs.